[1]赵 利,苏 玮,王 坤,等.经皮迷走神经耳支刺激改善心力衰竭犬的心功能研究[J].医学信息,2020,(11):58-60,71.[doi:10.3969/j.issn.1006-1959.2020.11.018]
 ZHAO Li,SU Wei,WANG Kun,et al.Percutaneous Vagus Nerve Branch Stimulation Improves Heart Function in Dogs with Heart Failure[J].Medical Information,2020,(11):58-60,71.[doi:10.3969/j.issn.1006-1959.2020.11.018]
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经皮迷走神经耳支刺激改善心力衰竭犬的心功能研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2020年11期
页码:
58-60,71
栏目:
综述
出版日期:
2020-06-01

文章信息/Info

Title:
Percutaneous Vagus Nerve Branch Stimulation Improves Heart Function in Dogs with Heart Failure
文章编号:
1006-1959(2020)11-0058-04
作者:
赵 利苏 玮王 坤
(1.新疆医科大学第一附属医院心力衰竭科,新疆 乌鲁木齐 830054;2.贵州医科大学第二附属医院,贵州 凯里 556000)
Author(s):
ZHAO LiSU WeiWANG Kunet al
(1.Department of Heart Failure,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China;2.The Second Affiliated Hospital of Guizhou Medical University,Kaili 556000,Guizhou,China)
关键词:
心力衰竭迷走神经耳支心功能心衰犬
Keywords:
Heart failureVagus nerve ear branchHeart functionHeart failure dog
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2020.11.018
文献标志码:
A
摘要:
目的 探讨低强度经皮迷走神经耳支刺激(AB-VNS)治疗对心衰犬心功能改善情况的影响。方法 24只Beagle犬均植入起搏器,分成假手术组(n=8),心衰组(n=8),AB-VNS组(n=8)。假手术组仅植入起搏器但不起博;心衰组和AB-VNS组行起搏器起搏制作心衰模型,AB-VNS组给予低强度经皮耳迷走神经刺激治疗8周。心脏超声测量射血分数(EF)和左室舒张末期直径(LVEDD);酶联免疫吸附法测定血清NT-proBNP、CRP和TNF-α浓度;电生理方法检测心率、ERP;取心肌组织做Masson染色观察心肌组织形态学改变。结果 经皮耳迷走神经刺激治疗8周后AB-VNS组的EF[(53.50±2.59)%]高于心衰组[(45.17±3.06)%],LVEDD[(37.17±1.60)mm]小于心衰组[(53.83±6.15)mm],差异有统计学意义(P<0.05);AB-VNS组Nt-proBNP低于心衰组[(388.56±40.94)pg/ml vs (674.91±56.78)pg/ml]、CRP[(9.57±1.18)mg/L vs (9.57±1.18)mg/L]、TNF-α[(6.40±0.63)ng/L vs (10.82±0.88)ng/L]、静息心率[(124.17±7.30)bpm vs(146.67±8.14)bpm],ERP较心衰组延长[(158.50±5.24)ms vs(125.17±4.83)ms],差异有统计学意义(P<0.05)。AB-VNS组Masson染色示心肌细胞形态较规则,伴有少量胶原纤维。结论 低强度经皮迷走神经耳支刺激有助于提高心衰犬心射血分数、降低NT-proBNP和炎症因子,并减慢心率、延长有效不应期。
Abstract:
Objective To investigate the effect of low-intensity percutaneous vagal nerve branch stimulation (AB-VNS) on the improvement of heart function in dogs with heart failure.Methods All 24 Beagle dogs were implanted with pacemakers and divided into sham operation group (n=8), heart failure group (n=8), AB-VNS group (n=8). In the sham-operated group, only a pacemaker was implanted, but it was not worthwhile; the heart failure group and the AB-VNS group were paced to make a heart failure model, and the AB-VNS group was given low-intensity percutaneous ear vagus nerve stimulation treatment for 8 weeks. Cardiac ultrasound measures ejection fraction (EF) and left ventricular end-diastolic diameter (LVEDD); enzyme-linked immunosorbent assay to determine serum NT-proBNP, CRP and TNF-α concentration; electrophysiological methods to detect heart rate, ERP; take myocardial tissue for Masson staining was used to observe the morphological changes of myocardium.Results After 8 weeks of percutaneous ear vagus nerve stimulation treatment, the EF [(53.50±2.59)%] in the AB-VNS group was higher than the heart failure group [(45.17±3.06)%], and the LVEDD [(37.17±1.60) mm] was smaller than the heart failure group [(53.83±6.15)mm], the difference was statistically significant (P<0.05); AB-VNS group Nt-proBNP was lower than heart failure group [(388.56±40.94) pg/ml vs (674.91±56.78) pg/ml], CRP [(9.57±1.18) mg/L vs (9.57±1.18) mg/L], TNF-α [(6.40±0.63) ng/L vs (10.82±0.88)ng/L], resting heart rate [(124.17±7.30) bpm vs (146.67±8.14) bpm], ERP was longer than heart failure group [(158.50±5.24) ms vs (125.17±4.83) ms], the difference was statistically significant (P<0.05). Masson staining in AB-VNS group showed that the shape of myocardial cells was regular, with a small amount of collagen fibers.Conclusion Low-intensity percutaneous vagus nerve branch stimulation can help increase heart ejection fraction, reduce NT-proBNP and inflammatory factors, and slow heart rate and prolong the effective refractory period in dogs with heart failure.

参考文献/References:

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更新日期/Last Update: 1900-01-01