[1]周措毛,冯喜英,秦棕园.阻塞性睡眠呼吸暂停低通气综合征患者脑灰质VBM-MRI的研究拉[J].医学信息,2020,33(11):67-71.[doi:10.3969/j.issn.1006-1959.2020.11.021]
　LAZHOU Cuo-mao,FENG Xi-ying,QIN Zong-yuan.VBM-MRI Study of Gray Matter in Patients with Obstructive Sleep Apnea Hypopnea Syndrome[J].Medical Information,2020,33(11):67-71.[doi:10.3969/j.issn.1006-1959.2020.11.021]
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阻塞性睡眠呼吸暂停低通气综合征患者脑灰质VBM-MRI的研究拉()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年11期
页码:
67-71
栏目:
综述
出版日期:
2020-06-01

文章信息/Info

Title:
VBM-MRI Study of Gray Matter in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
文章编号:
1006-1959（2020）11-0067-05
作者:
周措毛; 冯喜英; 秦棕园
（青海大学附属医院呼吸科1，影像中心2，青海 西宁 810000）
Author(s):
LAZHOU Cuo-mao; FENG Xi-ying; QIN Zong-yuan
(Respiratory Department1,Imaging Center2,the Affiliated Hospital of Qinghai University,Xining810000,Qinghai,China)
关键词:
OSAHS; 磁共振成像; 体素形态学分析; 脑灰质
Keywords:
OSAHS; Magnetic resonance imaging; Voxel morphological analysis; Gray matter
分类号:
R766
DOI:
10.3969/j.issn.1006-1959.2020.11.021
文献标志码:
A
摘要:
目的 应用基于体素的形态学测量（VBM）技术初步探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对大脑微观结构的影响。方法 选择2018年1月~2019年12月我院确诊的55例OSAHS 患者（OSAHS组）和同期来院的35例健康体检者（对照组）作为研究对象，应用PHILIPS 3.0 T磁共振脑MRI-VBM技术测量两组脑结构灰质的变化情况，比较两组平均血氧饱和度（MSpO2）、最低氧饱和度（LSpO2）、AHI指数及各脑区的灰质体积。结果 OSAHS组MSpO2、LSpO2低于对照组，AHI指数高于对照组，差异有统计意义（P＜0.05）；OSAHS组左侧舌回、左侧梭状回、右侧小脑脚2区、左侧小脑脚2区、右侧小脑脚8区脑灰质体积大于对照组，右侧海马旁回脑灰质体积小于对照组，差异均有统计意义（P＜0.05）。结论 OSAHS患者间歇缺氧下可导致脑灰质有不同程度的变化，因此OSAHS可能对患者的脑结构有一定程度的影响。
Abstract:
Objective To explore the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) on the microstructure of the brain using voxel-based morphological measurement (VBM) technology.Methods 55 patients with OSAHS (OSAHS group) diagnosed in our hospital from January 2018 to December 2019 and 35 healthy medical examinees (control group) who came to the hospital during the same period were selected as the research objects.PHILIPS 3.0 T magnetic resonance brain MRI-VBM technology was used to measure the changes of gray matter in the two groups of brains, and the average blood oxygen saturation (MSpO2), minimum oxygen saturation (LSpO2), AHI index and gray matter volume of each brain area were compared.Results OSAHS group had lower MSpO2 and LSpO2 than control group, and AHI index was higher than control group, the difference was statistically significant (P<0.05); OSAHS group had left tongue gyrus, left fusiform gyrus, right cerebellar foot area 2, left cerebellum The gray matter volume in foot area 2 and right cerebellar foot area 8 was greater than that in the control group, and the gray matter volume in the right hippocampal gyrus was smaller than that in the control group,the differences were statistically significant (P<0.05).Conclusion Intermittent hypoxia in OSAHS patients can cause changes in brain gray matter to varying degrees, therefore, OSAHS may have a certain degree of influence on the patient’s brain structure.

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更新日期/Last Update: 1900-01-01