[1]张玉香.脑蛋白水解物联合尿激酶治疗急性脑卒中的效果[J].医学信息,2020,(11):114-115.[doi:10.3969/j.issn.1006-1959.2020.11.035]
 ZHANG Yu-xiang.Effect of Brain Protein Hydrolysate Combined with Urokinase on Acute Stroke[J].Medical Information,2020,(11):114-115.[doi:10.3969/j.issn.1006-1959.2020.11.035]
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脑蛋白水解物联合尿激酶治疗急性脑卒中的效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2020年11期
页码:
114-115
栏目:
临床研究
出版日期:
2020-06-01

文章信息/Info

Title:
Effect of Brain Protein Hydrolysate Combined with Urokinase on Acute Stroke
文章编号:
1006-1959(2020)11-0114-02
作者:
张玉香
(天津北大医疗海洋石油医院神经内科,天津 300452)
Author(s):
ZHANG Yu-xiang
(Department of Neurology,Tianjin Peking University Medical Offshore Oil Hospital,Tianjin 300452,China)
关键词:
急性脑卒中脑蛋白水解物尿激酶基质金属蛋白酶-9脑血流动力学
Keywords:
Acute strokeCerebral protein hydrolysateUrokinaseMatrix metalloproteinase-9Cerebral hemodynamics
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2020.11.035
文献标志码:
A
摘要:
目的 观察脑蛋白水解物联合尿激酶对急性脑卒中患者基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)及脑血流动力学的影响。方法 选择2018年7月~2019年6月我院收治的急性脑卒中患者92例,按随机数字表法将其分为对照组和观察组,各46例。对照组在常规治疗基础上应用尿激酶,观察组在对照组基础上加用脑蛋白水解物治疗。比较两组临床疗效、血清MMP-9、TNF-α水平、脑血流动力学指标[平均血流速度(Vmean)、平均血流量(Qmean)]及不良反应。结果 观察组总有效率为95.65%,高于对照组的80.43%,差异有统计学意义(P<0.05);观察组Vmean、Qmean均高于对照组,差异有统计学意义(P<0.05);观察组血清MMP-9、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);治疗期间仅观察组出现胃肠道反应1例,未经对症处理自行缓解。结论 急性脑卒中患者接受脑蛋白水解物、尿激酶联合治疗的效果确切,有助于下调血清细胞因子,改善脑血流动力学,恢复神经功能,且副作用少,安全性较高。
Abstract:
Objective To observe the effect of brain protein hydrolysate combined with urokinase on matrix metalloproteinase-9 (MMP-9), tumor necrosis factor-α (TNF-α) and cerebral hemodynamics in patients with acute stroke.Methods A total of 92 patients with acute stroke admitted to our hospital from July 2018 to June 2019 were selected and divided into a control group and an observation group with a random number table method, each with 46 cases. The control group was treated with urokinase on the basis of conventional treatment, and the observation group was treated with brain protein hydrolysate on the basis of the control group. The clinical efficacy, serum MMP-9, TNF-α levels, cerebral hemodynamic indexes [mean blood flow velocity (Vmean), mean blood flow (Qmean)] and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.65%, higher than 80.43% of the control group, the difference was statistically significant (P<0.05);Vmean and Qmean of the observation group were both higher than the control group, the difference was statistically significant (P<0.05);The levels of serum MMP-9 and TNF-α in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).During the treatment period, only 1 case of gastrointestinal reaction occurred in the observation group, and it eased itself without symptomatic treatment.Conclusion The treatment of acute cerebral stroke patients with brain protein hydrolysate and urokinase combined has a definite effect, which can help to reduce serum cytokines, improve cerebral hemodynamics, restore nerve function, and has fewer side effects and higher safety.

参考文献/References:

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更新日期/Last Update: 1900-01-01