[1]郭 冶,卢凤美,刘东璞.肝纤维化发病机制及大黄酸对肝纤维化的作用[J].医学信息,2020,33(12):27-32,.[doi:10.3969/j.issn.1006-1959.2020.12.010]
 GUO Ye,LU Feng-mei,LIU Dong-pu.The Pathogenesis of Hepatic Fibrosis and the Effect of Rhein on Hepatic Fibrosis[J].Medical Information,2020,33(12):27-32,.[doi:10.3969/j.issn.1006-1959.2020.12.010]
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肝纤维化发病机制及大黄酸对肝纤维化的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年12期
页码:
27-32,
栏目:
综述
出版日期:
2020-06-15

文章信息/Info

Title:
The Pathogenesis of Hepatic Fibrosis and the Effect of Rhein on Hepatic Fibrosis
文章编号:
1006-1959(2020)12-0027-07
作者:
郭 冶卢凤美刘东璞
(佳木斯大学基础医学院,黑龙江 佳木斯 154003)
Author(s):
GUO YeLU Feng-meiLIU Dong-pu
(Basic Medical School of Jiamusi University,Jiamusi 154003,Heilongjiang,China)
关键词:
肝纤维化大黄酸肝损伤
Keywords:
Hepatic fibrosisRheinLiver damage
分类号:
R575
DOI:
10.3969/j.issn.1006-1959.2020.12.010
文献标志码:
A
摘要:
《黄帝内经》里记载“肝者,将军之官,谋虑出焉”,可见肝脏是维持生命活动重要的器官,一旦因炎症、病毒、寄生虫等发生疾病,纤维化是肝损伤发展为肝硬化的必经阶段。肝纤维化是指各种病因引起的肝细胞发生炎症及坏死等变化,进而刺激肝脏中细胞外基质的合成与降解平衡失调,致纤维胶原生成及溶解减少,发生可逆性动态病理过程。大黄酸具有抗氧化应激与炎症、抗细胞凋亡、抗纤维化、调节糖脂代谢及抗癌等作用,尤其抗肝纤维化作用的研究受到越来越多学者的关注。研究表明,给予大黄酸预防或治疗,可抑制肌成纤维细胞增生及纤维胶原转运与合成,加速胶原溶解,减少胶原的形成与沉积,可逆转肝纤维化。本文就肝纤维化的发病机制及大黄酸抗肝纤维化的功效作一综述,以期为临床治疗提供参考。
Abstract:
It is recorded in Huangdi’s internal classic that "the liver is the official of the general, and how to plan". It can be seen that the liver is an important organ to maintain life activities. Once diseases occur due to inflammation, viruses, parasites, etc., fibrosis is the necessary stage for liver damage to develop into cirrhosis. Hepatic fibrosis refers to the reversible dynamic pathological process, which is caused by inflammation and necrosis of liver cells caused by various causes, and then stimulates the imbalance of synthesis and degradation of extracellular matrix in liver, resulting in the decrease of generation and dissolution of fibrocollagen. Rhein has the functions of anti oxidative stress and inflammation, anti apoptosis, anti fibrosis, regulation of glycolipid metabolism and anti-cancer. Especially, more and more scholars have paid attention to the research of anti fibrosis. The prevention or treatment of rhein can inhibit the proliferation of myofibroblasts and the transport and synthesis of fibrocollagen, accelerate the dissolution of collagen, reduce the formation and deposition of collagen, and reverse it hepatic fibrosis. This article reviews the pathogenesis of hepatic fibrosis and the effect of rhein on hepatic fibrosis.

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更新日期/Last Update: 1900-01-01