[1]唐 群.益气活血利水法治疗气虚血瘀型慢性心力衰竭合并高尿酸血症的疗效[J].医学信息,2020,33(12):152-154.[doi:10.3969/j.issn.1006-1959.2020.12.049]
 TANG Qun.Therapeutic Effect of Supplementing Qi and Promoting Blood Circulation and Diuresis on Chronic Heart Failure with Qi Deficiency and Blood Stasis Combined with Hyperuricemia[J].Medical Information,2020,33(12):152-154.[doi:10.3969/j.issn.1006-1959.2020.12.049]
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益气活血利水法治疗气虚血瘀型慢性心力衰竭合并高尿酸血症的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年12期
页码:
152-154
栏目:
中医中药
出版日期:
2020-06-15

文章信息/Info

Title:
Therapeutic Effect of Supplementing Qi and Promoting Blood Circulation and Diuresis on Chronic Heart Failure with Qi Deficiency and Blood Stasis Combined with Hyperuricemia
文章编号:
1006-1959(2020)12-0152-03
作者:
唐 群
(辽宁省大连市金州区中医医院心内科,辽宁 大连 116100)
Author(s):
TANG Qun
(Department of Cardiology,Jinzhou DistrictTraditional Chinese Medicine Hospital,Dalian116100,Liaoning,China)
关键词:
益气活血利水法气虚血瘀型慢性心力衰竭高尿酸血症
Keywords:
Supplementing qi and promoting blood circulation diuresisChronic heart failure with qi deficiency and blood stasis typeHyperuricemia
分类号:
R259
DOI:
10.3969/j.issn.1006-1959.2020.12.049
文献标志码:
A
摘要:
目的 探讨益气活血利水法治疗气虚血瘀型慢性心力衰竭(CHF)合并高尿酸血症(HUA)的临床疗效。方法 选取2019年1~12月在我院收治的气虚血瘀型CHF合并HUA患者90例为研究对象,采用随机数字表法分为对照组(46例)和治疗组(44例),对照组使用基础抗心衰药物治疗,治疗组在对照组基础上加用益气活血利水治疗,比较两组中医疗效、心功能疗效、尿酸(UA)、B型钠尿肽前体(NT-proBNP)和左室射血分数(LVEF)。结果 治疗组中医疗效总有效率为93.19%,心功能疗效有效率为90.91%,高于对照组的80.43%、78.26%,差异有统计学差异(P<0.05);治疗后,对照组NT-proBNP较治疗前降低,UA较治疗前升高,治疗组NT-proBNP、UA均较治疗前降低,且治疗组低于对照组,差异有统计学意义(P<0.05);两组治疗后LVEF均较治疗前升高,治疗组高于对照组,差异有统计学意义(P<0.05)。结论 益气活血利水治疗可以有效降低心衰合并高尿酸血症患者尿酸水平,改善心功能,应用效果确切。
Abstract:
Objective To explore the clinical effect of supplementing qi and promoting blood circulation diuresison chronic heart failure (CHF) combined with hyperuricemia (HUA) due to qi deficiency and blood stasis.Methods 90 patients with CHF combined with HUA of Qi deficiency and blood stasis type admitted to our hospital from January to December 2019 were selected as the research object. They were divided into a control group (46 cases) and a treatment group (44 cases) by random number table method. The control group used Basic anti-heart failure drug treatment, the treatment group added supplementing qi and promoting blood circulation diuresis treatment on the basis of the control group, comparing the two groups of Chinese medicine effect, heart function efficacy, uric acid (UA), B-type natriuretic peptide precursor (NT-proBNP) and left ventricular ejection fraction (LVEF).Results The total effective rate of medical effects in the treatment group was 93.19%, and the effective rate of cardiac function was 90.91%, which was higher than the control group’s 80.43% and 78.26%, the difference was statistically significant(P<0.05); after treatment, the control group NT-proBNP was lower than before treatment and UA was higher than before treatment. NT-proBNP and UA in the treatment group were lower than before treatment, and the treatment group was lower than the control group, the difference was statistically significant (P<0.05); LVEF after treatment in both groups compared with before treatment, the treatment group was higher than the control group, the difference was statistically significant (P<0.05).Conclusion Supplementing qi and promoting blood circulation diuresis can effectively reduce the uric acid level and improve heart function in patients with heart failure and hyperuricemia, and the application effect is definite.

参考文献/References:

[1]Tamariz L,Harzand A,Palacio A,et al.Uric acid as a predictor of all- cause mortality in heart failure:a meta-analysis[J].Congest Heart Fail,2011,17(1):25-30.[2]Hamaguchi S,Furumoto T,Tsuchihashi-Makaya M,et al.Hyperuricemia predicts adverse outcomes in patients with heart failure[J].Int J Cardiol,2011,151(2):143-147.[3]中华医学会心血管病学分会.中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2018[J].中华心血管病杂志,2018,10(46):765.[4]唐群.益气活血利水法治疗慢性心力衰竭利尿剂抵抗临床观察[J].医学信息,2016,33(11):228.[5]中国中西医结合学会心血管疾病专业委员会,中国医师协会中西医结合医师分会心血管病学专家委员会.慢性心力衰竭中西医结合诊疗专家共识[J].中国中西医结合杂志,2016,36(2):133-141.[6]王强,建国,许伟伟,等.当归拈痛汤及其拆方对实验性尿酸血症小鼠血尿酸的影响[J].现代中医药,2010,30(2):61-62.[7]张庆,张培影,陈永刚,等.黄芪保心合剂对心肌梗死后心衰大鼠心肌保护作用机制研究[J].江苏中医药,2017,49(4):78.[8]陆潭,张李阳,陈玉胜.一种黄芪药渣发酵产物的抗高尿酸血症活性[J].江苏农业科学,2013,41(9):288-291.[9]于娟,王晓梅.薏苡仁和茯苓提取物对黄嘌呤氧化酶的抑制作用[J].中国药物与临床,2014,14(1):30-32.[10]王晓梅,赵岩,刘丹,等.三种中药提取物对黄嘌呤氧化酶的抑制作用[J].氨基酸和生物资源,2013,35(1):57-60.[11]王爱华,金玥,吴越,等.具有黄嘌呤氧化酶抑制作用的中药及中成药治疗高尿酸血症研究进展[J].天津中医药,2019,36(12):1241-1245.[12]Ding XQ,Pan Y,Wang X,et al.Wuling San ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice[J].Chin J Nat Med,2013,11(3):214-221.

更新日期/Last Update: 1900-01-01