[1]朱明明,李占全,崔 森.MMP-9信号通路调控乳腺癌发展的机制[J].医学信息,2020,33(13):22-25.[doi:10.3969/j.issn.1006-1959.2020.13.007]
 ZHU Ming-ming,LI Zhan-quan,CUI Sen.Mechanism of MMP-9 Signaling Pathway Regulating Breast Cancer Development[J].Medical Information,2020,33(13):22-25.[doi:10.3969/j.issn.1006-1959.2020.13.007]
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MMP-9信号通路调控乳腺癌发展的机制()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年13期
页码:
22-25
栏目:
综述
出版日期:
2020-07-01

文章信息/Info

Title:
Mechanism of MMP-9 Signaling Pathway Regulating Breast Cancer Development
文章编号:
1006-1959(2020)13-0022-04
作者:
朱明明李占全崔 森
(1.青海大学医学院高原医学研究中心,青海 西宁 810001;2.青海大学附属医院血液科,青海 西宁 810001)
Author(s):
ZHU Ming-mingLI Zhan-quanCUI Sen
(1.Plateau Medical Research Center,Medical College of Qinghai University,Xining 810001,Qinghai,China;2.Department of Hematology,the Affiliated Hospital of Qinghai University,Xining 810001,Qinghai,China)
关键词:
MMP-9乳腺癌信号通路
Keywords:
MMP-9Breast cancerSignaling pathway
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2020.13.007
文献标志码:
A
摘要:
乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤,早期症状多不明显,晚期可发生癌细胞远处转移,出现全身多器官病变,增加临床治疗难度,严重影响患者生活质量和生命安全。目前,乳腺癌的发病机制尚不明确,研究乳腺癌的发生、发展,尤其是转移相关的调控机制对乳腺癌的治疗具有重要意义。近年来研究表明MMP-9相关信号通路与乳腺癌的发生发展密切相关。本文就MMP-9的结构与生物学功能及其介导的乳腺癌侵袭及转移机制与预后作一综述,以期为临床治疗提供参考。
Abstract:
Breast cancer is a malignant tumor that occurs in the epithelial tissue of the breast gland. The early symptoms are mostly insignificant. In the late stage, cancer cells can metastasize to a distant location, and there are multiple organ lesions throughout the body. This increases the difficulty of clinical treatment and seriously affects the quality of life and safety of patients. At present, the pathogenesis of breast cancer is not yet clear. It is of great significance to study the occurrence and development of breast cancer, especially the metabolic regulation mechanism for the treatment of breast cancer. Recent studies have shown that MMP-9-related signaling pathways are closely related to the occurrence and development of breast cancer. This article reviews the structure and biological function of MMP-9 and the mechanisms and prognosis of breast cancer invasion and metastasis mediated by it, in order to provide a reference for clinical treatment.

参考文献/References:

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更新日期/Last Update: 1900-01-01