[1]张同强,郑家峰,徐勇胜.暴发性肺炎支原体肺炎的临床特点及治疗[J].医学信息,2020,33(13):26-29,34.[doi:10.3969/j.issn.1006-1959.2020.13.008]
 ZHANG Tong-qiang,ZHENG Jia-feng,XU Yong-sheng.Clinical Features and Treatment of Fulminant Mycoplasma Pneumoniae Pneumonia[J].Medical Information,2020,33(13):26-29,34.[doi:10.3969/j.issn.1006-1959.2020.13.008]
点击复制

暴发性肺炎支原体肺炎的临床特点及治疗()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年13期
页码:
26-29,34
栏目:
综述
出版日期:
2020-07-01

文章信息/Info

Title:
Clinical Features and Treatment of Fulminant Mycoplasma Pneumoniae Pneumonia
文章编号:
1006-1959(2020)13-0026-05
作者:
张同强郑家峰徐勇胜
(天津市儿童医院/天津大学儿童医院呼吸科,天津 300027)
Author(s):
ZHANG Tong-qiangZHENG Jia-fengXU Yong-sheng
(Tianjin Children’s Hospital/Department of Respiratory Medicine,Tianjin University Children’s Hospital,Tianjin 300027,China)
关键词:
肺炎支原体FMPP临床特征发病机制
Keywords:
Mycoplasma pneumoniaeFMPPClinical featuresPathogenesis
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2020.13.008
文献标志码:
A
摘要:
肺炎支原体(MP)是儿童及青少年社区获得性肺炎及肺外疾病的常见病原之一,尽管肺炎支原体感染多有自限性,难治性肺炎支原体及耐药肺炎支原体感染已被越来越多的人所关注,但是伴随低氧血症的暴发和/或致死性病例时有发生。暴发性肺炎支原体肺炎(FMPP)指的是合并有呼吸衰竭或者威胁生命的肺炎支原体肺炎。此类病例的研究很少报道,临床危险大,本文现对暴发性肺炎支原体肺炎的临床特征、发病机制及治疗的研究进展作一综述。
Abstract:
Mycoplasma pneumoniae (MP) is one of the common pathogens of community-acquired pneumonia and extrapulmonary diseases in children and adolescents. Despite the self-limiting nature of mycoplasma pneumoniae infection, refractory mycoplasma pneumoniae and resistant mycoplasma pneumoniae infection have been more and more concerned,but there are frequent outbreaks and/or fatal cases associated with hypoxemia.Fulminant Mycoplasma Pneumoniae Pneumonia (FMPP) refers to Mycoplasma pneumoniae pneumonia with respiratory failure or life-threatening. Research on such cases is rarely reported, and the clinical risk is high. This article now reviews the research progress of clinical features, pathogenesis, and treatment of fulminant mycoplasma pneumoniae pneumonia.

参考文献/References:

[1]Yan C,Xue G,Zhao H,et al.Molecular and clinical characteristics of severe Mycoplasma pneumoniae pneumonia in children[J].Pediatr Pulmonol,2019,54(7):1012-1021.[2]Izumikawa K.Clinical Features of Severe or Fatal Mycoplasma pneumoniae Pneumonia[J].Front Microbiol,2016(7):800.[3]Bajantri B,Venkatram S,Diaz-Fuentes G.Mycoplasma pneumoniae:A Potentially Severe Infection[J].J Clin Med Res,2018, 10(7):535-544.[4]Moynihan KM,Barlow A,Nourse C,et al.Severe Mycoplasma Pneumoniae Infection in Children Admitted to Pediatric Intensive Care[J].Pediatr Infect Dis J,2018,37(12):e336-e338.[5]Miyashita N,Obase Y,Ouchi K,et al.Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit[J].J Med Microbiol,2007,56(12):1625-1629.[6]Izumikawa K,Takazono T,Kosai K,et al.Clinical features,risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: a review of the Japanese literature[J].J Infect Chemother,2014,20(3):181-185.[7]Miyashita N,Akaike H,Teranishi H,et al.Macrolide-resistant Mycoplasma pneumoniae pneumonia in adolescents and adults: clinical findings,drug susceptibility, and therapeutic efficacy[J].Antimicrob Agents Chemother,2013,57(10):5181-5185.[8]Heith CS,Hume JR,Steiner ME,et al.Fulminant Mycoplasma Infection Requiring ECMO in a Previously Healthy Child: Case Report and Review[J].J Pediatr Intensive Care,2018,7(2):106-109.[9]Park SJ,Pai KS,Kim AR,et al.Fulminant and Fatal Multiple Organ Failure in a 12-Year-Old Boy With Mycoplasma pneumoniae Infection[J].Allergy Asthma Immunol Res,2012,4(1):55-57.[10]Hon KL,Leung AS,Cheung KL,et al.Typical or atypical pneumonia and severe acute respiratory symptoms in PICU[J].Clin Respir J,2015,9(3):366-371.[11]Garcia AV,Fingeret AL,Thirumoorthi AS,et al.Severe Mycoplasma pneumoniae infection requiring extracorporeal membrane oxygenation with concomitant ischemic stroke in a child[J].Pediatr Pulmonol,2013,48(1):98-101.[12]Petitjean-Lecherbonnier J,Dina J,Gouarin S,et al.Mycoplasma pneumoniae and Chlamydophila pneumoniae coinfection in severe pneumoniae among a hospitalized child with respiratory distress: what are the best diagnostic tools for an optimal care?[J].Pathol Biol(Paris),2010,58(6):434-436.[13]Kannan TR,Hardy RD,Coalson JJ,et al.Fatal outcomes in family transmission of Mycoplasma pneumoniae[J].Clin Infect Dis,2012,54(2):225-231.[14]Demitsu T,Kawase M,Nagashima K,et al.Mycoplasma pneumoniae-associated mucositis with severe blistering stomatitis and pneumonia successfully treated with azithromycin and infusion therapy[J].J Dermatol,2019,46(1):e38-e39.[15]Tsai YG,Ou TY,Wang CC,et al.Intravenous gamma-globulin therapy in myocarditis complicated with complete heart block:Report of one case[J].Acta Paediatr Taiwan,2001,42(5):311-313.[16]Kurugol Z,Onen SS,Koturoglu G.Severe Hemolytic Anemia Associated with Mild Pneumonia Caused by Mycoplasma pneumonia[J].Case Rep Med,2012(2012):649850.[17]Wang W,Shen KL.Mycoplasma pneumonia associated with cerebral infarction in 3 children[J]. Chinese Journal of Pediatrics,2009,47(12):946-949.[18]Stettner M,Albrecht P,Derksen A,et al.Clinical improvement precedes lesion size regression in a severe case of acute disseminated encephalomyelitis[J].BMJ Case Rep,2012(2012):bcr-2012-006844.[19]Mizukane R,Kadota JJ,Yamaguchi T,et al.An elderly patient with hemophagocytic syndrome due to severe mycoplasma pneumonia with marked hypercytokinemia[J].Respiration,2002,69(1):87-91.[20]Khan FY,Sayed H.Rhabdomyolysis associated with Mycoplasma pneumoniae pneumonia[J].Hong Kong Med J,2012,18(3):247-249.[21]Wandro C,Dolatshahi L,Blackall D.Severe Warm Autoimmune Hemolytic Anemia in a 7-Month-Old Infant Associated With a Mycoplasma Pneumoniae Infection[J].J Pediatr Hematol Oncol,2018,40(7):e439-e441.[22]Gu L,Chen X,Li H,et al.A case of lethal hemolytic anemia associated with severe pneumonia caused by Mycoplasma pneumoniae[J].Chin Med J (Engl),2014,127(21):3839.[23]Al Yazidi LS,Hameed H,Kesson A,et al.A 6-year-old girl with severe, focal Mycoplasma pneumoniae pneumonia[J].J Paediatr Child Health,2019,55(1):107-109.[24]Murayama A,Abukawa D,Watanabe K,et al.Severe liver dysfunction in patients with Mycoplasma pneumoniae infection[J].Pediatr Int,2010,52(2):e105-e107.[25]Xu W,Guo L,Dong X,et al.Detection of Viruses and Mycoplasma pneumoniae in Hospitalized Patients with Severe Acute Respiratory Infection in Northern China,2015-2016[J].Jpn J Infect Dis,2018,71(2):134-139.[26]Tsuruta R,Kawamura Y,Inoue T,et al.Corticosteroid therapy for hemolytic anemia and respiratory failure due to Mycoplasma pneumoniae pneumonia[J].Intern Med,2002,41(3):229-232.[27]Liu J,He R,Wu R,et al.Mycoplasma pneumoniae pneumonia associated thrombosis at Beijing Children’s hospital[J].BMC Infect Dis,2020,20(1):51.[28]Li Y,Williams RJ,Dombrowski ND,et al.Current evaluation and management of plastic bronchitis in the pediatric population[J].Int J Pediatr Otorhinolaryngol,2020(130):109799.[29]Miyashita N,Narita M,Tanaka T,et al.Histological findings in severe Mycoplasma pneumoniae pneumonia[J].J Med Microbiol,2017,66(5):690-692.[30]Wang K,Gao M,Yang M,et al.Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency[J].Hum Genomics,2017,11(1):4.[31]Li G,Fan L,Wang Y,et al.High co-expression of TNF-α and CARDS toxin is a good predictor for refractory Mycoplasma pneumoniae pneumonia[J].Mol Med,2019,25(1):38.[32]Chkhaidze I,Kapanadze N.Cytokynes as the Predictors of Severe Mycoplasma Pneumoniae Pneumonia in Children (Review)[J].Georgian Med News,2017(267):89-95.[33]Ding S,Wang X,Chen W,et al.Decreased Interleukin-10 Responses in Children with Severe Mycoplasma pneumoniae Pneumonia[J].PLoS One,2016,11(1):e0146397.[34]Miyashita N,Kawai Y,Inamura N,et al.Setting a standard for the initiation of steroid therapy in refractory or severe Mycoplasma pneumoniae pneumonia in adolescents and adults[J].J Infect Chemother,2015,21(3):153-160.[35]Cheong KN,Chiu SS,Chan BW,et al.Severe macrolide-resistant Mycoplasma pneumoniae pneumonia associated with macrolide failure[J].J Microbiol Immunol Infect,2016,49(1):127-130.[36]Jae-Won O.The efficacy of glucocorticoid on macrolide resistant Mycoplasma pneumonia in children[J].Allergy Asthma Immunol Res,2014,6(1):3-5.[37]Kosugi Y,Katsura H.A case of fulminant Mycoplasma pneumoniae pneumonia despite adequate antibiotic treatment[J].Nihon Kokyuki Gakkai Zasshi,2009,47(6):471-475.[38]Shen Y,Zhang J,Hu Y,et al.Combination therapy with immune-modulators and moxifloxacin on fulminant macrolide-resistant Mycoplasma pneumoniae infection:A case report[J].Pediatr Pulmonol,2013,48(5):519-522.[39]Takiguchi Y,Shikama N,Aotsuka N,et al.Fulminant Mycoplasma pneumoniae pneumonia[J].Intern Med,2001,40(4):345-348.[40]Xu F,Dai CL,Wu XM,et al.Overwhelming postsplenectomy infection due to Mycoplasma pneumoniae in an asplenic cirrhotic patient:case report[J].BMC Infect Dis,2011(11):162.

相似文献/References:

[1]李 娇,林 琳.儿童呼吸道感染者肺炎支原体及肺炎衣原体特异性抗体检测临床意义[J].医学信息,2019,32(03):96.[doi:10.3969/j.issn.1006-1959.2019.03.029]
 LI Jiao,LI Lin.Clinical Significance of Detection of Specific Antibodies Against Mycoplasma Pneumoniae and Chlamydia Pneumoniae in Children with Respiratory Tract Infection[J].Medical Information,2019,32(13):96.[doi:10.3969/j.issn.1006-1959.2019.03.029]
[2]郭昱瑄,张盛玉,王熙业,等.肺炎支原体实验室诊断的研究进展[J].医学信息,2019,32(11):26.[doi:10.3969/j.issn.1006-1959.2019.11.008]
 GUO Yu-xuan,ZHANG Sheng-Yu,WANG Xi-ye,et al.Progress in Laboratory Diagnosis of Mycoplasma Pneumoniae[J].Medical Information,2019,32(13):26.[doi:10.3969/j.issn.1006-1959.2019.11.008]
[3]石连霞.口咽部正常菌群对肺炎支原体快速培养法试剂盒的影响[J].医学信息,2019,32(11):171.[doi:10.3969/j.issn.1006-1959.2019.11.053]
 SHI Lian-xia.Effect of Normal Oropharyngeal Flora on Kit for Rapid Culture of Mycoplasma Pneumoniae[J].Medical Information,2019,32(13):171.[doi:10.3969/j.issn.1006-1959.2019.11.053]
[4]周彩虹.小儿呼吸系统感染后肺炎支原体抗体检测的意义[J].医学信息,2020,33(10):175.[doi:10.3969/j.issn.1006-1959.2020.10.054]
 ZHOU Cai-hong.Significance of Detection of Mycoplasma Pneumoniae Antibody After Respiratory Infection in Children[J].Medical Information,2020,33(13):175.[doi:10.3969/j.issn.1006-1959.2020.10.054]
[5]白经纬.微生物快速培养检测在小儿肺炎支原体感染中的诊断价值[J].医学信息,2022,35(24):151.[doi:10.3969/j.issn.1006-1959.2022.24.033]
 BAI Jing-wei.Diagnostic Value of Rapid Microbial Culture Detection in Mycoplasma Pneumoniae Infection in Children[J].Medical Information,2022,35(13):151.[doi:10.3969/j.issn.1006-1959.2022.24.033]

更新日期/Last Update: 1900-01-01