[1]姜 博,刘 艳.贝前列素钠辅助治疗对偏头痛患者血浆5-HT、β-EP、NT水平的影响[J].医学信息,2020,33(13):154-155.[doi:10.3969/j.issn.1006-1959.2020.13.046]
　JIANG Bo,LIU Yan.Effect of Adjuvant Therapy with Beraprost Sodium on Plasma 5-HT,β-EP and NT Levels in Migraine Patients[J].Medical Information,2020,33(13):154-155.[doi:10.3969/j.issn.1006-1959.2020.13.046]
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贝前列素钠辅助治疗对偏头痛患者血浆5-HT、β-EP、NT水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年13期
页码:
154-155
栏目:
药物与临床
出版日期:
2020-07-01

文章信息/Info

Title:
Effect of Adjuvant Therapy with Beraprost Sodium on Plasma 5-HT,β-EP and NT Levels in Migraine Patients
文章编号:
1006-1959（2020）13-0154-02
作者:
姜 博; 刘 艳
（佳木斯市中心医院神经内1科，黑龙江 佳木斯 154002）
Author(s):
JIANG Bo; LIU Yan
(Department of Neurology,Subject One,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
偏头痛; 贝前列素钠; 5-羟色胺; β-内啡肽; 神经降压素
Keywords:
Migraine; Beraprost sodium; 5-HT; β-endorphin; Neurotensin
分类号:
R511.5
DOI:
10.3969/j.issn.1006-1959.2020.13.046
文献标志码:
A
摘要:
目的 探讨贝前列素钠辅助治疗对偏头痛患者血浆5-羟色胺（5-HT）、β-内啡肽（β-EP）、神经降压素（NT）水平的影响。方法 选择2017年12月~2019年11月我院收治的82例偏头痛患者作为研究对象，采用随机数字表法分为对照组和观察组，各41例。对照组给予盐酸氟桂利嗪胶囊治疗，观察组在对照组基础上联合贝前列素钠治疗。比较两组治疗1个月后临床症状评分、血浆5-HT、β-EP及NT水平。结果 治疗1个月后两组头痛发作次数、头痛持续时间及伴随症状得分均低于治疗前，且观察组低于对照组（P＜0.05）；两组血浆5-HT、NT水平均低于治疗前，β-EP水平高于治疗前，且观察组优于对照组（P＜0.05）。结论 贝前列素钠辅助治疗偏头痛，可有效降低患者头痛发作次数、持续时间及伴发症状程度，改善患者血浆5-HT、β-EP、NT水平，从而提高治疗效果。
Abstract:
Objective To investigate the effects of adjuvant therapy with beraprost sodium on plasma serotonin (5-HT), β-endorphin (β-EP) and neurotensin (NT) levels in patients with migraine.Methods 82 migraine patients admitted to our hospital from December 2017 to November 2019 were selected as the research object.They were divided into a control group and an observation group with a random number table method, each with 41 cases. The control group was treated with flunarizine hydrochloride capsules, and the observation group was treated with beraprost sodium on the basis of the control group. The clinical symptom score, plasma 5-HT, β-EP and NT levels were compared between the two groups after 1 month of treatment.Results After 1 month of treatment, the number of headache attacks, headache duration, and accompanying symptom scores were lower than before treatment, and the observation group was lower than the control group(P<0.05);The levels of plasma 5-HT and NT in the two groups were lower than before treatment, and β-EP levels were higher than before treatment, and the observation group was superior to the control group(P<0.05).Conclusion The adjuvant treatment of beraprost sodium can effectively reduce the number of headache attacks, the duration and the degree of symptomatic symptoms, improve the patient’s plasma 5-HT, β-EP, NT levels, thereby improving the treatment effect.

参考文献/References:

[1]高红红,陈玉.天麻素注射液联合盐酸氟桂利嗪治疗偏头痛的效果观察[J].卒中与神经疾病,2019,26(5):569-572.[2]刘静.养血清脑颗粒联合氟桂利嗪治疗偏头痛临床效果观察[J].中医药信息,2019,36(5):106-108.[3]头面痛学组.中国偏头痛诊断治疗指南[J].中国疼痛医学杂志,2011,17(2):65-86.[4]湖南省医院协会.临床疾病诊断与疗效判断标准[M].北京:科学技术文献出版社,2010:399.[5]康锦芬,李靖云,黄文森,等.贝前列素钠联合硫辛酸对糖尿病周围神经病变患者TCSS评分、MDNS评分及神经传导速度的影响[J].川北医学院学报,2019,34(2):190-193.

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更新日期/Last Update: 1900-01-01