[1]李毓龙,刘 琴,黄倩倩.免疫球蛋白检测在乙型肝炎患者的应用价值[J].医学信息,2020,33(13):173-174.[doi:10.3969/j.issn.1006-1959.2020.13.055]
　LI Yu-long,LIU Qin,HUANG Qian-qian.Application Value of Immunoglobulin Detection in Patients with Hepatitis B[J].Medical Information,2020,33(13):173-174.[doi:10.3969/j.issn.1006-1959.2020.13.055]
点击复制

免疫球蛋白检测在乙型肝炎患者的应用价值()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年13期
页码:
173-174
栏目:
诊疗技术
出版日期:
2020-07-01

文章信息/Info

Title:
Application Value of Immunoglobulin Detection in Patients with Hepatitis B
文章编号:
1006-1959（2020）13-0173-02
作者:
李毓龙; 刘 琴; 黄倩倩
（简阳市人民医院检验科，四川 简阳 641400）
Author(s):
LI Yu-long; LIU Qin; HUANG Qian-qian
(Department of Laboratory,Jianyang People’s Hospital,Jianyang 641400,Sichuan,China)
关键词:
免疫球蛋白检验; 乙型肝炎; 应用价值
Keywords:
Immunoglobulin test; Hepatitis B; Application value
分类号:
R446
DOI:
10.3969/j.issn.1006-1959.2020.13.055
文献标志码:
A
摘要:
目的 探究免疫球蛋白检验在乙型肝炎患者中的应用价值。方法 选取2018年9月~2019年8月我院收治的120例乙型肝炎患者，依据疾病类型将患者分为急性乙肝组、慢性乙肝组、慢性重型乙肝组及肝硬化组，每组30例；另选取同期在我院进行体检的60例健康者作为对照组，比较各组免疫球蛋白[免疫球蛋白G（IgG）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白E（IgE）]检测结果。结果 急性乙肝组、慢性乙肝组、慢性重型乙肝组及肝硬化组血清IgA、IgG、IgM、IgE均高于对照组，差异有统计学意义（P＜0.05）；其中慢性重型乙型组各项免疫球蛋白指标水平最高，其次是肝硬化组、慢性乙肝组、急性乙肝组。结论 免疫球蛋白的水平随着病情的加重逐渐升高，以慢性重型乙肝患者最为突出，其可作为乙型肝炎患者肝功能检测的评判指标，对患者疾病的诊断、分型及预后具有非常重要的意义。
Abstract:
Objective To Explore the application value of immunoglobulin test in patients with hepatitis B.Methods 120 patients with hepatitis B admitted to our hospital from September 2018 to August 2019 were selected, and the patients were divided into acute hepatitis B group, chronic hepatitis B group, chronic severe hepatitis B group and cirrhosis group according to the type of disease, 30 cases in each group; In addition, 60 healthy people who were examined in our hospital during the same period were selected as the control group, and the results of immunoglobulin[immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin E (IgE)] were compared between the groups.Results Serum IgA, IgG, IgM, IgE in acute hepatitis B group, chronic hepatitis B group, chronic severe hepatitis B group and cirrhosis group were higher than the control group, the difference was statistically significant (P<0.05); The level of globulin index was the highest, followed by cirrhosis group, chronic hepatitis B group, and acute hepatitis B group.Conclusion The level of immunoglobulin gradually increases with the aggravation of the disease, and it is most prominent in patients with chronic severe hepatitis B. It can be used as a judging indicator for liver function detection in patients with hepatitis B, and is very important for the diagnosis, classification and prognosis of patients’ diseases.

参考文献/References:

[1]Hadziyannis SJ,Sevastianos V,Rapti I.Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stoplong-term treatment with adefovir[J].Gastroenterology,2012,143(3):629-636.[2]王浩,陈春晖.血清免疫球蛋白在乙型肝炎患者的临床应用价值[J].实验与检验医学,2018,36(6):895-896,905.[3]Stanaway JD,Flaxman AD,Naghavi M,et al.The global burden of viral hepatitis from 1990 to 2013:findings from the Global Burden of Disease Study 2013[J].Lancet,2016,388(10049):1081-1088.[4]郭琪.《人民日报》乙肝报道的议题建构[D].山西大学,2013.[5]龚建平,廖汪洋,何益平.Kupffer细胞与HBV慢性感染引起的肝损伤[J].世界华人消化杂志,2008,16(24):2735-2740.[6]赵瑞斌,赵振江.对丙种球蛋白在临床应用中的再认识[J]. 内科,2007,2(3):381-383.

相似文献/References:

[1]李安乐,戴 夫,彭 琼.中性粒细胞与淋巴细胞比值、红细胞体积分布宽度与乙型肝炎及乙型肝炎肝硬化的关系研究[J].医学信息,2019,32(03):69.[doi:10.3969/j.issn.1006-1959.2019.03.022]
　LI An-le,DAI Fu,PENG Qiong.Relationship between Neutrophil-lymphocyte Ratio,Red Blood Cell Volume Distribution Width and Hepatitis B and Hepatitis B Cirrhosis[J].Medical Information,2019,32(13):69.[doi:10.3969/j.issn.1006-1959.2019.03.022]
[2]王媛媛.乙型肝炎患者血清免疫球蛋白检测的意义[J].医学信息,2018,31(18):155.[doi:10.3969/j.issn.1006-1959.2018.18.050]
　WANG Yuan-yuan.Significance of Detection of Serum Immunoglobulin in Patients with Hepatitis B[J].Medical Information,2018,31(13):155.[doi:10.3969/j.issn.1006-1959.2018.18.050]
[3]桂志兵,汪文生.红细胞分布宽度与血小板计数比值在乙型肝炎肝硬化患者病情评估中的作用[J].医学信息,2018,31(20):65.[doi:10.3969/j.issn.1006-1959.2018.20.019]
　GUI Zhi-bing,WANG Wen-sheng.The Role of Red Blood Cell Distribution Width and Platelet Ratio in the Evaluation of Patients with Hepatitis B Cirrhosis[J].Medical Information,2018,31(13):65.[doi:10.3969/j.issn.1006-1959.2018.20.019]
[4]洪 亮,陶 静,张 静,等.上海市男性同性恋HIV感染者中乙型肝炎、丙型肝炎病毒的合并感染情况横断面研究[J].医学信息,2019,32(06):145.[doi:10.3969/j.issn.1006-1959.2019.06.046]
　HONG Liang,TAO Jing,ZHANG Jing,et al.Cross-sectional Study on the Co-infection of Hepatitis B and Hepatitis C Virus among HIV-infected People in Shanghai[J].Medical Information,2019,32(13):145.[doi:10.3969/j.issn.1006-1959.2019.06.046]
[5]裴金仙,陈天狮,任巧晶,等.IL-23在慢性乙型肝炎免疫调节中的作用研究[J].医学信息,2019,32(08):129.[doi:10.3969/j.issn.1006-1959.2019.08.037]
　PEI Jin-xian,CHEN Tian-shi,REN Qiao-jing,et al.The Role of IL-23 in the Immune Regulation of Chronic Hepatitis B[J].Medical Information,2019,32(13):129.[doi:10.3969/j.issn.1006-1959.2019.08.037]
[6]方志军.实时荧光PCR检测乙肝病毒DNA的效果评价[J].医学信息,2019,32(22):175.[doi:10.3969/j.issn.1006-1959.2019.22.062]
　FANG Zhi-jun.Evaluation of the Effect of Real-time Fluorescent PCR on Detection of Hepatitis B Virus DNA[J].Medical Information,2019,32(13):175.[doi:10.3969/j.issn.1006-1959.2019.22.062]
[7]肖岑昕,黄恒青.肠道微生物群与慢性病毒性肝炎的关系[J].医学信息,2021,34(21):39.[doi:10.3969/j.issn.1006-1959.2021.21.009]
　XIAO Cen-xin,HUANG Heng-qing.Relationship Between Intestinal Microflora and Chronic Viral Hepatitis[J].Medical Information,2021,34(13):39.[doi:10.3969/j.issn.1006-1959.2021.21.009]
[8]王明杰,秦玉杰.聚乙二醇干扰素α序贯联合核苷类药物治疗高病毒载量e抗原阳性乙型肝炎的疗效[J].医学信息,2021,34(19):107.[doi:10.3969/j.issn.1006-1959.2021.19.027]
　WANG Ming-jie,QIN Yu-jie.Efficacy of Peginterferon α Sequential Combined with Nucleoside Drugs in theTreatment of High Viral Load e Antigen Positive Hepatitis B[J].Medical Information,2021,34(13):107.[doi:10.3969/j.issn.1006-1959.2021.19.027]

更新日期/Last Update: 1900-01-01