[1]潘小玉,张再伟,李 虎.吲哚布芬治疗不稳定型心绞痛的有效性和安全性的Meta分析[J].医学信息,2020,33(14):80-84.[doi:10.3969/j.issn.1006-1959.2020.14.023]
 PAN Xiao-yu,ZHANG Zai-wei,LI Hu.Meta Analysis of the Efficacy and Safety of Indobufen in the Treatment of Unstable Angina[J].Medical Information,2020,33(14):80-84.[doi:10.3969/j.issn.1006-1959.2020.14.023]
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吲哚布芬治疗不稳定型心绞痛的有效性和安全性的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年14期
页码:
80-84
栏目:
论著
出版日期:
2020-07-15

文章信息/Info

Title:
Meta Analysis of the Efficacy and Safety of Indobufen in the Treatment of Unstable Angina
文章编号:
1006-1959(2020)14-0080-05
作者:
潘小玉张再伟李 虎
(1.济宁医学院临床医学院,山东 济宁 272067;2.济宁市第一人民医院心血管内科,山东 济宁 272011;3.济宁市第一人民医院心血管病研究所,山东 济宁 272011)
Author(s):
PAN Xiao-yuZHANG Zai-weiLI Hu
(1.Clinical Medical College,Jining Medical College,Jining 272067,Shandong,China;2.Department of Cardiology,Jining No.1 People’s Hospital,Jining 272011,Shandong,China;3.Cardiovascular Research Institute,Jining No.1 People’s Hospital,Jining 272011, Shando
关键词:
吲哚布芬阿司匹林不稳定型心绞痛Meta分析
Keywords:
IndobufenAspirinUnstable anginaMeta analysis
分类号:
R54;R743
DOI:
10.3969/j.issn.1006-1959.2020.14.023
文献标志码:
A
摘要:
目的 评价吲哚布芬对比阿司匹林治疗不稳定型心绞痛的有效性和安全性,为临床提供循证依据。方法 计算机检索万方、知网、中国生物医学文献数据库、PubMed、Embase、Cochrane Library、Medline数据库,检索吲哚布芬治疗不稳定型心绞痛的有效性和安全性且对照组为阿司匹林的研究,检索时间从建库至2019年11月20日。应用Rev Man5.3软件对纳入的研究进行分析。结果 总共纳入8项研究,合计992例患者,随访时间为4~6周。Meta分析结果显示:吲哚布芬组相比于阿司匹林组心绞痛发作次数减少[MD=-0.16,95%CI(-0.27,-0.05),P=0.006],发作持续时间降低[MD=-2.36,95%CI(-2.92,-1.80),P<0.00001];两组总不良反应发生率[OR=0.11,95%CI(0.06,0.20),P<0.00001]、胃肠道反应[OR=0.18,95%CI(0.08,0.42),P<0.0001]、消化道出血[OR=0.14,95%CI(0.02,0.81),P=0.03]比较,差异有统计学意义,两组心绞痛每次发作持续时间及皮疹发生率比较,差异无统计学意义(P>0.05)。结论 吲哚布芬治疗不稳定型心绞痛疗效优于阿司匹林,且安全性更高。
Abstract:
Objective To evaluate the efficacy and safety of indobufen versus aspirin in the treatment of unstable angina pectoris, and to provide evidence-based evidence for clinical practice.Methods Computer search Wanfang, HowNet, China Biomedical Literature Database, PubMed, Embase, Cochrane Library, Medline database to search the efficacy and safety of indobufen for unstable angina pectoris and the control group was aspirin. The time interval is from the construction of the library to November 20, 2019. The Rev Man5.3 software was used to analyze the included studies.Results A total of 8 studies were included and a total of 992 patients were followed up for 4-6 weeks. Meta analysis results showed that the number of angina attacks decreased in the indobufen group compared to the aspirin group [MD=-0.16, 95%CI(-0.27, -0.05),P=0.006], and the duration of attacks decreased [MD=-2.36 , 95%CI (-2.92,-1.80), P<0.00001]; the total incidence of adverse reactions in both groups [OR=0.11, 95%CI (0.06,0.20), P<0.00001], gastrointestinal reactions [OR=0.18, 95%CI (0.08,0.42),P<0.0001], gastrointestinal bleeding [OR=0.14, 95%CI (0.02,0.81),P=0.03], the duration of each episode of angina and the incidence of rash in comparison, the difference was not statistically significant (P>0.05).Conclusion Indobufen is better than aspirin in the treatment of unstable angina pectoris, and it is more safe.

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更新日期/Last Update: 1900-01-01