[1]包学智.经肝动脉化疗栓塞联合射频消融术治疗中晚期原发性肝癌的效果[J].医学信息,2020,33(19):110-112.[doi:10.3969/j.issn.1006-1959.2020.19.033]
　BAO Xue-zhi.The Effect of Transhepatic Artery Chemoembolization Combined with Radiofrequency Ablation in the Treatment of Advanced Primary Liver Cancer[J].Medical Information,2020,33(19):110-112.[doi:10.3969/j.issn.1006-1959.2020.19.033]
点击复制

经肝动脉化疗栓塞联合射频消融术治疗中晚期原发性肝癌的效果()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年19期
页码:
110-112
栏目:
临床研究
出版日期:
2020-10-01

文章信息/Info

Title:
The Effect of Transhepatic Artery Chemoembolization Combined with Radiofrequency Ablation in the Treatment of Advanced Primary Liver Cancer
文章编号:
1006-1959（2020）19-0110-03
作者:
包学智
天津市津南医院普外科，天津 300000
Author(s):
BAO Xue-zhi
General Surgery,Tianjin Jinnan Hospital,Tianjin 300000,China
关键词:
肝动脉化疗; 射频消融; 原发性肝癌
Keywords:
Hepatic artery chemotherapy; Radiofrequency ablation; Primary liver cancer
分类号:
R735.7
DOI:
10.3969/j.issn.1006-1959.2020.19.033
文献标志码:
A
摘要:
目的 探讨经肝动脉化疗栓塞联合射频消融术治疗中晚期原发性肝癌的临床疗效。方法 选取2018年2月~2020年2月我院诊治的54例中晚期原发性肝癌患者为研究对象，采用随机数字表法分为对照组和观察组，各27例。对照组采用经肝动脉化疗栓塞治疗，观察组在对照组基础上给予射频消融术治疗，比较两组临床治疗总有效率、肿瘤直径、肝功能指标[甲胎蛋白（AFP）、血清总胆红素（TBIL）、谷丙转氨酶（ALT）]、生存率及并发症发生情况。结果 观察组治疗总有效率为92.59%，高于对照组的81.48%，差异有统计学意义（P＜0.05）；观察组肿瘤直径小于对照组，差异有统计学意义（P＜0.05）；术后，两组AFP、TBIL均低于术前，ALT高于治疗前，且观察组AFP、TBIL低于对照组，ALT高于对照组，差异有统计学意义（P＜0.05）；观察组并发症发生率为7.40%，与对照组的11.11%比较，差异无统计学意义（P＞0.05）。结论 经肝动脉化疗栓塞联合射频消融术治疗中晚期原发性肝癌疗效确切，可缩小肿瘤直径，改善肾功能，提高患者生存率，且不增加并发症发生几率，治疗安全性高。
Abstract:
Objective To investigate the clinical efficacy of transhepatic arterial chemoembolization combined with radiofrequency ablation in the treatment of advanced primary liver cancer.Methods 54 patients with intermediate and advanced primary liver cancer diagnosed and treated in our hospital from February 2018 to February 2020 were selected as the research objects. They were divided into control group and observation group by random number table method, with 27 cases in each group. The control group was treated with transhepatic arterial chemoembolization, and the observation group was treated with radiofrequency ablation on the basis of the control group. The total effective rate of clinical treatment, tumor diameter, liver function indexes [alpha-fetoprotein (AFP), serum total bilirubin (TBIL), alanine aminotransferase (ALT)], survival rate and complications.Results The total effective rate of treatment in the observation group was 92.59%, which was higher than 81.48% in the control group,the difference was statistically significant (P<0.05); the tumor diameter in the observation group was smaller than the control group,the difference was statistically significant (P<0.05);After operation, AFP and TBIL of the two groups were lower than before operation, ALT was higher than before treatment, AFP and TBIL of observation group were lower than control group, ALT was higher than control group, the difference was statistically significant (P<0.05);The complication rate in the observation group was 7.40%, which was not statistically significant compared with 11.11% in the control group (P>0.05).Conclusion Transhepatic arterial chemoembolization combined with radiofrequency ablation had a definite effect in the treatment of advanced primary liver cancer. It could reduce tumor diameter, improve renal function, and improve patient survival without increasing the probability of complications. The treatment was safe.

参考文献/References:

[1]赵灵华,曾斌.贝伐单抗联合肝动脉化疗栓塞术治疗原发性肝癌的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(2):126-128. [2]金鑫荔,卢伟.TACE联合阿帕替尼治疗中晚期肝细胞癌[J].中国介入影像与治疗学,2017,14(4):200-204. [3]周福平,杨喜晶,王真,等.脾多肽注射液联合经导管肝动脉化疗栓塞治疗中晚期原发性肝癌[J].第二军医大学学报,2017,38(3):379-382. [4]付斯瑜,任汝仙,王美江,等.肝动脉灌注化疗栓塞联合高强度聚焦超声治疗中晚期原发性肝癌的临床观察[J].中国药房,2015,26(35):4978-4980. [5]王保信,武振明,张锐,等.联合应用雷替曲塞及表柔比星经肝动脉化疗栓塞术治疗中晚期原发性肝癌的临床观察[J].临床肝胆病杂志,2015,31(5):725-728. [6]付宁,李正平,罗道蕴,等.肝动脉化疗栓塞术中植入氟尿嘧啶、奥沙利铂、吡柔比星治疗中晚期原发性肝癌的临床研究[J].成都医学院学报,2015,10(6):652-656. [7]Lopez-Gomez M,Moreno-Rubio J,Suarez-Garcia I,et al.Gene expression differences in primary colorectaltumors and matched liver metastases:chemotherapy related or tumoral heterogeneity[J].Clinical and Translational Oncology,2015,17(4):322-329. [8]杨泽冉,苏天昊,尉建安,等.肝动脉化疗栓塞术联合阿帕替尼治疗中晚期原发性肝癌疗效评价[J].中国肿瘤临床,2017,44(17):880-885. [9]马英,孙韬,李玉苓,等.原发性肝癌TACE术后射频消融联合生物治疗对免疫功能及血管内皮生长因子的影响研究[J].河北医药,2016,38(12):1828-1832. [10]张王山,刘东晓,黄国金.经导管肝动脉化疗栓塞术对中晚期原发性肝癌的疗效[J].江苏医药,2018,44(5):573-574. [11]庄炜钊,黄晨,姬智艳,等.TACE 联合氩氦刀冷冻消融治疗中 晚期肝癌的疗效分析[J].医学影像学杂志,2016,26(12):2247-2250. [12]侯鲁强,刘军伟,迟强,等.精细肝动脉栓塞化疗联合射波刀治疗中晚期原发性肝癌[J].实用医药杂志,2016,33(6):519-520. [13]陈习波,宋华志,何远春,等.氩氦刀冷冻消融联合肝动脉插管化疗栓塞治疗原发性肝癌的疗效研究[J].实用癌症杂志,2015,30(11):1710-1712. [14]魏玉芳,武纪生,霍志刚,等.斑蝥酸钠维生素B6注射液联合介入栓塞化疗治疗中晚期原发性肝癌48例疗效评价[J].中国药业,2015,24(5):72-74. [15]郭飞,张晓阳,聂双发,等.经导管化疗栓塞联合经皮微波消融治疗中晚期原发性肝癌患者的疗效研究[J].实用癌症杂志,2015,30(6):877-879.

相似文献/References:

[1]朱志成,陈玉赞.鼻中隔矫正联合筛前神经射频消融治疗变应性鼻炎伴鼻中隔偏曲的疗效分析[J].医学信息,2018,31(23):111.[doi:10.3969/j.issn.1006-1959.2018.23.030]
　ZHU Zhi-cheng,CHEN Yu-zan.The Curative Effect Analysis of Nasal Septal Reconstruction Combined with Nervus Ethmoidalis Anterior Under Radiofrequency Ablation for Allergic Rhinitis Patients with Septal Deviation[J].Medical Information,2018,31(19):111.[doi:10.3969/j.issn.1006-1959.2018.23.030]

更新日期/Last Update: 1900-01-01