[1]朱 昕,熊 丹.不同模式乙肝五项与HBV-DNA定量及ALT的关系研究[J].医学信息,2020,33(19):162-164.[doi:10.3969/j.issn.1006-1959.2020.19.052]
　ZHU Xin,XIONG Dan.Study on the Relationship Between Five Hepatitis B Items in Different Models, HBV-DNA Quantification and ALT[J].Medical Information,2020,33(19):162-164.[doi:10.3969/j.issn.1006-1959.2020.19.052]
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不同模式乙肝五项与HBV-DNA定量及ALT的关系研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年19期
页码:
162-164
栏目:
诊疗技术
出版日期:
2020-10-01

文章信息/Info

Title:
Study on the Relationship Between Five Hepatitis B Items in Different Models, HBV-DNA Quantification and ALT
文章编号:
1006-1959（2020）19-0162-03
作者:
朱 昕; 熊 丹
高安市人民医院检验科，江西 高安 330800
Author(s):
ZHU Xin; XIONG Dan
Department of Laboratory Medicine,Gaoan People’s Hospital,Gaoan 330800,Jiangxi,China
关键词:
乙肝五项; HBV-DNA; 血清标志物ALT; 慢性乙型肝炎
Keywords:
Five items of hepatitis B; HBV-DNA; Serum marker ALT; Chronic hepatitis B
分类号:
R512.6+2
DOI:
10.3969/j.issn.1006-1959.2020.19.052
文献标志码:
A
摘要:
目的 探讨不同模式乙肝五项与乙型肝炎病毒DNA（HBV-DNA）及血清丙氨酸氨基转移酶（ALT）相关性分析。方法 选择2018年1~6月在高安市人民医院确诊的509例乙型肝炎病毒（HBV）阳性患者为研究对象，乙肝五项用酶联免疫吸附试验（ELISA）、HBV-DNA用荧光定量PCR（FQ-PCR）法、ALT用乳酸脱氢酶法测定。根据乙肝五项的结果分为A组大三阳（HBsAg+、HBeAg+、HBcAb＋）、B组小三阳（HBsAg+、HBeAb+、HBcAb+）、C组小二阳（HBsAg＋、HBcAb＋），分析不同模式乙肝五项与HBV-DNA及ALT相关性。结果 ①A组HBV-DNA定量阳性率（87.50%）高于B组（50.64%）和C组（34.33%），B组阳性率高于C组，差异有统计学意义（P＜0.05）；②A组HBV-DNA定量＞1.0×105比例（64.84%）高于B组（18.47%）和C组（30.43%），A组HBV-DNA定量＜1.0×104比例（23.08%）低于B组（64.33%）、C组（60.87%）；三组HBV-DNA定量为1.0×104~1.0×105的比例在10%~20%；③509例乙肝患者血清中ALT≥50 U/L有70例，A组中ALT≥50 U/L的比例（34.61%）高于B组（0.90%）、C组（0.89%），差异有统计学意义（P＜0.05），但B组与C组ALT≥50 U/L的比例比较，差异无统计学意义（P＞0.05）。结论 不同模式乙肝五项检测结果与HBV-DNA量及血清酶ALT含量有关，对不同模式的乙型肝炎患者采取不同模式模式乙肝五项检测，对乙肝诊治具有临床意义。
Abstract:
Objective To explore the correlation analysis of five different models of hepatitis B with hepatitis B virus DNA (HBV-DNA) and serum alanine aminotransferase (ALT).Methods A total of 509 hepatitis B virus (HBV) positive patients diagnosed in Gao’an People’s Hospital from January to June 2018 were selected as the research subjects. Five hepatitis B items were tested by enzyme-linked immunosorbent assay (ELISA) and HBV-DNA by fluorescence quantitative PCR (FQ-PCR) method, ALT was determined by lactate dehydrogenase method. According to the results of the five items of hepatitis B, they were divided into three major yang (HBsAg+, HBeAg+, HBcAb+) in group A, three small yang (HBsAg+, HBeAb+, HBcAb+) in group B, and two small yang (HBsAg+, HBcAb+) in group C. Five hepatitis B items of different modes were analyzed. Correlation with HBV-DNA and ALT.Results ①The positive rate of HBV-DNA in group A (87.50%) was higher than that of group B (50.64%) and group C (34.33%). The positive rate of group B was higher than that of group C,the difference was statistically significant (P＜0.05); ②The ratio of HBV-DNA quantification＞1.0×105 (64.84%) in group A was higher than that of group B (18.47%) and group C (30.43%), and the ratio of HBV-DNA quantification ＜1.0×104 (23.08%) in group A was lower than that of group B (64.33%), group C (60.87%); the proportion of the three groups with HBV-DNA quantification of 1.0×104~1.0×105 is 10%~20%; ③There were 70 cases of 509 patients with hepatitis B in serum ALT≥50 U/L. The proportion of ALT≥50 U/L in group A (34.61%) was higher than that in group B (0.90%) and group C (0.89%),the difference was statistically significant (P＜0.05), but there was no significant difference in the ratio of ALT≥50 U/L between group B and group C (P＞0.05).Conclusion The five test results of different models of hepatitis B were related to the amount of HBV-DNA and the content of serum enzyme ALT. The five test results of different models of hepatitis B for patients with different models of hepatitis B had clinical significance for the diagnosis and treatment of hepatitis B.

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更新日期/Last Update: 1900-01-01