[1]姚安琪,郑艳辉.托伐普坦治疗肾脏疾病的应用[J].医学信息,2020,33(24):53.[doi:10.3969/j.issn.1006-1959.2020.24.015]
 YAO An-qi,ZHENG Yan-hui.Application of Tolvaptan in Treating Kidney Disease[J].Medical Information,2020,33(24):53.[doi:10.3969/j.issn.1006-1959.2020.24.015]
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托伐普坦治疗肾脏疾病的应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年24期
页码:
53
栏目:
综述
出版日期:
2020-12-15

文章信息/Info

Title:
Application of Tolvaptan in Treating Kidney Disease
文章编号:
1006-1959(2020)24-0053-04
作者:
姚安琪1郑艳辉2
1.南京中医药大学,江苏 南京 210029; 2.南京中医药大学附属南京中医院肾病科,江苏 南京 210001
Author(s):
YAO An-qi1ZHENG Yan-hui2
1.Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China; 2.Department of Nephrology,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210001,Jiangsu,China
关键词:
托伐普坦心肾综合征肝肾综合征肾病综合征利尿剂抵抗常染色体显性多囊肾病造影剂肾病
Keywords:
TolvaptanCardiorenal syndromeHepatorenal syndromeNephrotic syndromeDiuretic resistanceAutosomal dominant polycystic kidney diseaseContrast nephropathy
分类号:
R59
DOI:
10.3969/j.issn.1006-1959.2020.24.015
文献标志码:
A
摘要:
托伐普坦(TLV)是一种新型选择性精氨酸加压素V2受体拮抗剂,可促进自由水的排出而减轻容量负荷,自上市以来主要应用于非低血容量性低钠血症伴心力衰竭、肝硬化及抗利尿激素分泌异常综合征(SIADH)的医治。近来,国内外进行了多项将托伐普坦运用于治疗肾脏疾病的临床研究,取得较好疗效,如心肾综合征、肝肾综合征、肾病综合征、利尿剂抵抗、常染色体显性多囊肾病(ADPKD)、造影剂肾病等,本文将对其近年在治疗肾脏疾病方面的研究作一综述,以促进对托伐普坦药物使用新认识,拓展肾脏疾病治疗新思路。
Abstract:
Tolvaptan (TLV) is a new selective arginine vasopressin V2 receptor antagonist, which can promote the excretion of free water and reduce the volume load. It has been mainly used in non-hypovolemic hypovolemia Treatment of natriemia with heart failure, liver cirrhosis and syndrome of abnormal antidiuretic hormone secretion (SIADH). Recently, a number of clinical studies on the application of tolvaptan in the treatment of kidney diseases have been carried out at home and abroad, and have achieved good results, such as cardiorenal syndrome, hepatorenal syndrome, nephrotic syndrome, diuretic resistance, autosomal dominant Polycystic kidney disease (ADPKD), contrast-medium nephropathy, etc. This article will review its recent research in the treatment of renal diseases, in order to promote new understanding of the use of tolvaptan drugs and expand new ideas for the treatment of renal diseases.

参考文献/References:

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更新日期/Last Update: 1900-01-01