[1]韩燕红,张瑞霞.PGC-1α的生理特性及其影响因素[J].医学信息,2021,34(02):42-45.[doi:10.3969/j.issn.1006-1959.2021.02.012]
 HAN Yan-hong,ZHANG Rui-xia.Physiological Characteristics of PGC-1α and Its Influencing Factors[J].Medical Information,2021,34(02):42-45.[doi:10.3969/j.issn.1006-1959.2021.02.012]
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PGC-1α的生理特性及其影响因素()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年02期
页码:
42-45
栏目:
综述
出版日期:
2021-01-15

文章信息/Info

Title:
Physiological Characteristics of PGC-1α and Its Influencing Factors
文章编号:
1006-1959(2021)02-0042-04
作者:
韩燕红张瑞霞
(青海大学附属医院内分泌科,青海 西宁 810000)
Author(s):
HAN Yan-hongZHANG Rui-xia
(Department of Endocrinology,Affiliated Hospital of Qinghai University,Xining 810000,Qinghai,China)
关键词:
PGC-1α低温低氧生理效应
Keywords:
PGC-1αLow temperatureHypoxiaPhysiological effects
分类号:
R363
DOI:
10.3969/j.issn.1006-1959.2021.02.012
文献标志码:
A
摘要:
PPARγ共激活因子1α(PGC-1α)是一种诱导型转录共激活因子,可通过介导线粒体各种信号转导通路,发挥其促进或抑制的中间调节剂作用,从而有许多特异性的生理效应。PGC-1α分布广泛,与肥胖、糖尿病以及脂代谢紊乱密切相关,且其表达受低氧、低温、运动、病理情况及其他因素等调节。本文主要就PGC-1α的生理特性及相关因素影响PGC-1α表达水平作一综述。
Abstract:
PPARγ co-activator 1α(PGC-1α) is an inducible transcriptional co-activator, which can play the role of intermediate regulator promoted or inhibited by mediating various signal transduction pathways in mitochondria, thus having many specific physiological effects.PGC-1α is widely distributed and closely related to obesity, diabetes and lipid metabolism disorders, and its expression is regulated by hypoxia, hypothermia, exercise, pathological conditions and other factors.This article mainly reviews the physiological characteristics of PGC-1α and related factors affecting PGC-1α expression level.

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更新日期/Last Update: 1900-01-01