[1]闫 梦,李 伟,康大伟,等.慢性心力衰竭患者精神状态与营养状况、IL-6、Ghrelin水平相关分析[J].医学信息,2021,34(03):78-81,87.[doi:10.3969/j.issn.1006-1959.2021.03.023]
　YAN Meng,LI Wei,KANG Da-wei,et al.Correlation Analysis of Mental State and Nutritional Status,IL-6 and Ghrelin Levels in Patients with Chronic Heart Failure[J].Medical Information,2021,34(03):78-81,87.[doi:10.3969/j.issn.1006-1959.2021.03.023]
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慢性心力衰竭患者精神状态与营养状况、IL-6、Ghrelin水平相关分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年03期
页码:
78-81,87
栏目:
论著
出版日期:
2021-02-01

文章信息/Info

Title:
Correlation Analysis of Mental State and Nutritional Status,IL-6 and Ghrelin Levels in Patients with Chronic Heart Failure
文章编号:
1006-1959（2021）03-0078-05
作者:
闫 梦; 李 伟; 康大伟; 等
（1.承德医学院，河北 承德 067000； 2.承德医学院附属医院，河北 承德 067000）
Author(s):
YAN Meng; LI Wei; KANG Da-wei; et al.
(1.Chengde Medical University,Chengde 067000,Hebei,China; 2.The Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China)
关键词:
慢性心衰; 焦虑抑郁; 营养状况; IL-6; Ghrelin
Keywords:
Chronic heart failure; Anxiety and depression; Nutritional status; IL-6; Ghrelin
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2021.03.023
文献标志码:
A
摘要:
目的 探究慢性心力衰竭（CHF）患者焦虑抑郁情况，分析其对患者营养状况、静脉血IL-6、Ghrelin水平的影响。方法 选取2017年4月~2018年12月于承德医学院附属医院住院治疗的89例CHF患者作为研究对象，采用汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HRSD）量表及微型营养评估量表（MNA）评估患者身体状况，检测血清IL-6、Ghrelin水平，分析其精神状态与营养状况、血清IL-6、Ghrelin的相关性。结果 89例患者中无焦虑抑郁症状36例（40.45%），单纯焦虑13例（14.61%），单纯抑郁16例（17.98%），合并焦虑抑郁24例（26.97%）；营养良好37例（41.57%），潜在营养不良29例（32.58%），营养不良23例（25.84%）；线性回归分析显示，CHF患者精神状态与营养状况呈负相关，回归系数位为-0.580；Pearson相关分析显示，CHF患者精神状态与L-6、Ghrelin水平呈正相关（r=0.759、0.769）。结论 CHF患者焦虑抑郁伴发率高，且伴焦虑抑郁患者营养状况差；血清IL-6、Ghrelin水平随患者精神状态的改变而升高。临床治疗心力衰竭的同时应关注以上指标并进行早期干预，从而改善患者的生活质量及预后。
Abstract:
Objective To explore the anxiety and depression of patients with chronic heart failure (CHF), and analyze its effect on the nutritional status, venous blood IL-6, and Ghrelin levels.Methods 89 patients with CHF who were hospitalized in the Affiliated Hospital of Chengde Medical University from April 2017 to December 2018 were selected as the research subjects, and the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HRSD) scale were used and the Mini Nutritional Assessment Scale (MNA) to assess the patient’s physical condition, detect the serum IL-6 and Ghrelin levels, and analyze the correlation between their mental state and nutritional status, serum IL-6 and Ghrelin.Results Among the 89 patients, 36 cases had no anxiety and depression symptoms (40.45%), 13 cases were simple anxiety (14.61%), 16 cases were simple depression (17.98%), and 24 cases were combined with anxiety and depression (26.97%);37 cases (41.57%) with good nutrition, 29 cases (32.58%) with potential malnutrition, and 23 cases (25.84%) with malnutrition;Linear regression analysis showed that the mental state of CHF patients was negatively correlated with nutritional status, and the regression coefficient was -0.580;Pearson correlation analysis showed that the mental state of CHF patients was positively correlated with L-6 and Ghrelin levels (r=0.759, 0.769).Conclusion CHF patients have a high incidence of anxiety and depression, and patients with anxiety and depression have poor nutritional status; serum IL-6 and Ghrelin levels increase with the changes in the patients’ mental state. In the clinical treatment of heart failure, attention should be paid to the above indicators and early intervention, so as to improve the patient’s quality of life and prognosis.

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更新日期/Last Update: 1900-01-01