[1]苏长阳,帅东东,王 磊,等.硝普钠联合多巴胺治疗心肌梗死后左心衰竭的疗效[J].医学信息,2021,34(03):157-159.[doi:10.3969/j.issn.1006-1959.2021.03.044]
　SU Chang-yang,SHUAI Dong-dong,WANG Lei,et al.Efficacy of Sodium Nitroprusside Combined with Dopamine in the Treatment of Left Heart Failure After Myocardial Infarction[J].Medical Information,2021,34(03):157-159.[doi:10.3969/j.issn.1006-1959.2021.03.044]
点击复制

硝普钠联合多巴胺治疗心肌梗死后左心衰竭的疗效()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年03期
页码:
157-159
栏目:
药物与临床
出版日期:
2021-02-01

文章信息/Info

Title:
Efficacy of Sodium Nitroprusside Combined with Dopamine in the Treatment of Left Heart Failure After Myocardial Infarction
文章编号:
1006-1959（2021）03-0157-03
作者:
苏长阳; 帅东东; 王 磊; 等
（首都医科大学石景山教学医院/北京市石景山医院心内科，北京 100023）
Author(s):
SU Chang-yang; SHUAI Dong-dong; WANG Lei; et al.
(Department of Cardiology,Shijingshan Teaching Hospital of Capital Medical University/Beijing Shijingshan Hospital, Beijing 100023,China)
关键词:
心肌梗死; 左心衰竭; 硝普钠; 多巴胺
Keywords:
Myocardial infarction; Left heart failure; Sodium nnitroprusside; Dopamine
分类号:
R542.22
DOI:
10.3969/j.issn.1006-1959.2021.03.044
文献标志码:
A
摘要:
目的 观察硝普钠联合多巴胺治疗心肌梗死后左心衰竭的临床疗效。方法 选取2018年5月~2020年5月我院接诊的74例心肌梗死后左心衰竭患者为研究对象，采用随机数字表法分为对照组和观察组，各37例。对照组采用巴胺单药治疗，观察组在对照组基础上联合多巴胺治疗，比较两组临床治疗总有效率、心功能指标、临床症状缓解时间、、血压和心率以及临床不良反应发生情况。结果 观察组临床治疗总有效率为94.59%，高于对照组的81.08%，差异有统计学意义（P＜0.05）；治疗后两组每搏输出量、LVEF、LVESD均高于治疗前，LVEDD均低于治疗前，且观察组每搏输出量、LVEF、LVESD高于对照组，LVEDD低于对照组，差异有统计学意义（P＜0.05）；观察组临床心衰症状缓解时间短于对照组，差异有统计学意义（P＜0.05）；治疗后两组舒张压、收缩压、心率均低于治疗前，但观察组高于对照组，差异有统计学意义（P＜0.05）；观察组临床不良反应发生率为2.70%，低于对照组的10.81%，差异有统计学意义（P＜0.05）。结论 硝普钠与多巴胺两药配合用于心肌梗死后左心衰竭患者的治疗效果确切，可改善心功能指标，短时间内控制心衰竭，同时对血压和心率影响小，且不增加不良反应发生几率，应用安全。
Abstract:
Objective To observe the clinical efficacy of sodium nitroprusside combined with dopamine in the treatment of left heart failure after myocardial infarction.Methods A total of 74 patients with left heart failure after myocardial infarction were selected from May 2018 to May 2020 in our hospital. They were divided into control group and observation group by random number table, with 37 cases in each group.The control group was treated with pamine monotherapy, and the observation group was combined with dopamine treatment on the basis of the control group. The total effective rate of clinical treatment, cardiac function indexes, clinical symptom relief time, blood pressure and heart rate, and clinical adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 94.59%, which was higher than 81.08% in the control group,the difference was statistically significant (P<0.05);After treatment, stroke volume, LVEF and LVESD of both groups were higher than before treatment.LVEDD was lower than before treatment, stroke volume, LVEF, LVESD of the observation group were higher than those of the control group, and LVEDD was lower than the control group, the difference was statistically significant (P<0.05);The relief time of clinical heart failure symptoms in the observation group was shorter than that in the control group,the difference was statistically significant (P<0.05);After treatment, the diastolic blood pressure, systolic blood pressure, and heart rate of the two groups were lower than before treatment, but the observation group was higher than the control group, the difference was statistically significant (P<0.05);The incidence of clinical adverse reactions in the observation group was 2.70%, which was lower than 10.81% in the control group,the difference was statistically significant (P<0.05).Conclusion The combined treatment of sodium nitroprusside and dopamine in patients with left heart failure after myocardial infarction has a definite therapeutic effect, which can improve the index of heart function, control heart failure in a short time, and has little effect on blood pressure and heart rate, and does not increase the occurrence of adverse reactions Probability, application security.

参考文献/References:

[1]吴文建,凌宗攀.多巴胺结合硝普钠治疗心肌梗死后左心力衰竭116例分析[J].系统医学,2019,4(14):70-72. [2]毕剑波,于生龙,薛久巍.硝普钠联合多巴胺治疗心肌梗死后左心衰竭的疗效观察[J].中国医院用药评价与分析,2018,18(6):44-46. [3]张雪松.多巴胺联合硝普钠治疗心肌梗死后左心衰竭的临床效果分析[J].中国医药指南,2020,18(18):144-145. [4]欧文森,彭慕立,杨为民,等.应用多巴胺联合硝普钠在治疗心梗后左心衰中的临床疗效评价[J].黑龙江医药,2017,30(2):311-312. [5]张萌.大剂量多巴胺及硝普钠抢救急性心肌梗死休克的临床研究[J].中国继续医学教育,2017,9(19):168-169. [5]武君.硝普钠和多巴胺治疗急性心力衰竭的临床疗效[J].中国社区医师,2018,28(4):50. [6]王占礼.人脑利钠肽与硝普钠在治疗急性心肌梗死并急性心力衰竭中的疗效对比研究[J].国际心血管病杂志,2017,15(A01):152. [6]张传烨,叶雪科.多巴胺联合硝普钠治疗心梗后左心衰的临床疗效分析[J].现代诊断与治疗,2017,28(1):81-82. [7]左希宏,张艳玲,陈欢.左西孟旦联合无创正压通气治疗急性心肌梗死后急性左心衰竭的效果观察[J].中国当代医药,2015,22(24):60-62,65. [8]卫生部心血管系统药物临床药理基地.心血管系统药物临床研究指导原则[J].中国临床药理学杂志,1988(4):245-255. [9]王洪云,赵拥军,秦亮.左西孟旦治疗急性心肌梗死后左心衰竭LVEF、LVEDD、NT-proBP、hs-CRR的变化与临床意义[J].滨州医学院学报,2017,40(3):175-177,214. [10]张一峰,李树仁,刘肖,等.未伴心力衰竭的非ST段抬高型心肌梗死患者院内急性左心衰竭的影响因素研究[J].实用心脑肺血管病杂志,2019,27(12):33-37. [11]明兆生,刘建兴.多巴胺联合硝普钠治疗心梗后左心衰35例疗效分析[J].中西医结合心血管病电子杂志,2018,6(2):74. [12]陈亮,林松,陈绍良,等.左西孟坦治疗急性心肌梗死合并心力衰竭患者的疗效研究[J].心血管康复医学杂志,2014,22(6):598-601. [13]Chen YH,Kuo TT,Huang YK.Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell[J].Oncotarget,2018,9(11):10016-10028． [14]葛晓丽,靳丽君,赵静,等.阿托伐他汀联合硝普钠治疗慢性心力衰竭临床评价[J].中国药业,2019,28(12):84-86. [15]宫丹丹.多巴胺联合硝普钠治疗心梗后左心衰的临床疗效观察[J].中国现代药物应用,2016,10(16):178-179.

相似文献/References:

[1]冯 湧.新一代抗凝血药阿加曲班的临床应用进展[J].医学信息,2018,31(02):43.[doi:10.3969/j.issn.1006-1959.2018.02.015]
　FENG Yong.Progress in Clinical Application of the New Generation Anticoagulant Agatripine[J].Medical Information,2018,31(03):43.[doi:10.3969/j.issn.1006-1959.2018.02.015]
[2]翟公伟,赵培华,滑 艳.30岁以下急性ST段抬高型心肌梗死患者临床特点分析[J].医学信息,2018,31(05):81.[doi:10.3969/j.issn.1006-1959.2018.05.026]
　ZHAI Gong-wei,ZHAO Pei-hua,HUA Yan.Clinical Characteristics of Acute ST-segment Elevation Myocardial Infarction under 30 Years of Age[J].Medical Information,2018,31(03):81.[doi:10.3969/j.issn.1006-1959.2018.05.026]
[3]杜浩珲.溶栓后PCI与pPCI治疗急性ST段抬高型心肌梗死的 临床效果研究[J].医学信息,2018,31(08):69.[doi:10.3969/j.issn.1006-1959.2018.08.021]
　DU Hao-hun.Clinical Effect of PCI and pPCI on Acute ST Segment Elevation Myocardial Infarction after Thrombolysis[J].Medical Information,2018,31(03):69.[doi:10.3969/j.issn.1006-1959.2018.08.021]
[4]宋俊燕,张 毅.重组人尿激酶原在急性ST段抬高型心肌梗死中的 疗效及并发症分析[J].医学信息,2018,31(11):133.[doi:10.3969/j.issn.1006-1959.2018.11.042]
　SONG Jun-yan,ZHANG Yi.Therapeutic Efficacy and Complications of Recombinant Human Pro-urokinase in Acute ST-elevation Myocardial Infarction[J].Medical Information,2018,31(03):133.[doi:10.3969/j.issn.1006-1959.2018.11.042]
[5]李素军.早期心脏康复运动治疗方案对急性非ST段抬高 心肌梗死的效果观察[J].医学信息,2018,31(15):89.[doi:10.3969/j.issn.1006-1959.2018.15.027]
　LI Su-jun.Effect of Early Cardiac Rehabilitation Exercise on Acute Non-ST-Elevation Myocardial Infarction[J].Medical Information,2018,31(03):89.[doi:10.3969/j.issn.1006-1959.2018.15.027]
[6]金 鹏,周炳凤.去甲肾上腺素在心肌梗死合并低血压中的应用[J].医学信息,2020,33(07):57.[doi:10.3969/j.issn.1006-1959.2020.07.017]
　JIN Peng,ZHOU Bing-feng.Application of Norepinephrine in Myocardial Infarction with Hypotension[J].Medical Information,2020,33(03):57.[doi:10.3969/j.issn.1006-1959.2020.07.017]
[7]朱贝利,刘 辉,耿硕章,等.心肌梗死后缺血性心肌病心衰患者血浆半乳糖凝集素3的表达及其临床意义[J].医学信息,2020,33(15):61.[doi:10.3969/j.issn.1006-1959.2020.15.020]
　ZHU Bei-li,LIU Hui,GENG Shuo-zhang,et al.Expression of Plasma Galectin-3 in Patients with Ischemic Cardiomyopathy and Heart Failure After Myocardial Infarction and Its Clinical Significance[J].Medical Information,2020,33(03):61.[doi:10.3969/j.issn.1006-1959.2020.15.020]
[8]张 宁,孙经武,刘 振,等.鸢尾素与心血管疾病的相关性[J].医学信息,2021,34(02):56.[doi:10.3969/j.issn.1006-1959.2021.02.016]
　ZHANG Ning,SUN Jing-wu,LIU Zhen,et al.Study on the Correlation Between Irisin and Cardiovascular Disease[J].Medical Information,2021,34(03):56.[doi:10.3969/j.issn.1006-1959.2021.02.016]
[9]邓 伟.冠脉无复流的危险因素及治疗[J].医学信息,2021,34(03):43.[doi:10.3969/j.issn.1006-1959.2021.03.013]
　DENG Wei.Risk Factors and Treatment of No-reflow of Coronary Artery[J].Medical Information,2021,34(03):43.[doi:10.3969/j.issn.1006-1959.2021.03.013]
[10]王小忠,常先松,赵良平,等.桥接整合因子1与心血管疾病的关系研究[J].医学信息,2022,35(01):46.[doi:10.3969/j.issn.1006-1959.2022.01.011]
　WANG Xiao-zhong,CHANG Xian-song,ZHAO Liang-ping,et al.Research of the Relationship Between Bridging Integrator 1 and Cardiovascular Diseases[J].Medical Information,2022,35(03):46.[doi:10.3969/j.issn.1006-1959.2022.01.011]
[11]王 铮.不同院前急救方式对心肌梗死后急性左心衰竭救治效果及预后的影响[J].医学信息,2022,35(12):169.[doi:10.3969/j.issn.1006-1959.2022.12.042]
　WANG Zheng.Effect of Different Pre-hospital Emergency Methods on Treatment and Prognosis of Acute Left Heart Failure After Myocardial Infarction[J].Medical Information,2022,35(03):169.[doi:10.3969/j.issn.1006-1959.2022.12.042]

更新日期/Last Update: 1900-01-01