[1]朱文书,张理想,游杨杨,等.长链非编码RNA MIAT表达水平与心房颤动导管消融术后复发的关系[J].医学信息,2021,34(04):75-77.[doi:10.3969/j.issn.1006-1959.2021.04.020]
　ZHU Wen-shu,ZHANG Li-xiang,YOU Yang-yang,et al.Relationship Between the Expression Level of Long Non-coding RNA MIAT and Recurrence After Catheter Ablation of Atrial Fibrillation[J].Medical Information,2021,34(04):75-77.[doi:10.3969/j.issn.1006-1959.2021.04.020]
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长链非编码RNA MIAT表达水平与心房颤动导管消融术后复发的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
75-77
栏目:
论著
出版日期:
2021-02-15

文章信息/Info

Title:
Relationship Between the Expression Level of Long Non-coding RNA MIAT and Recurrence After Catheter Ablation of Atrial Fibrillation
文章编号:
1006-1959（2021）04-0075-03
作者:
朱文书; 张理想; 游杨杨; 等
（1.安徽医科大学附属省立医院心内科，安徽 合肥 230001； 2.中国科学技术大学附属第一医院心内科，安徽 合肥 230001）
Author(s):
ZHU Wen-shu; ZHANG Li-xiang; YOU Yang-yang; et al.
(1.Department of Cardiovascular Medicine,Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui,China； 2.Department of Cardiovascular Medicine,the First Affiliated Hospital of University of Science and Technology of China, Hefei 230
关键词:
长链非编码RNA MIAT; 心房颤动; 导管消融术; 复发
Keywords:
Long non-coding RNA MIAT;  Atrial fibrillation;  Catheter ablation;  Recurrence
分类号:
R541.7+5
DOI:
10.3969/j.issn.1006-1959.2021.04.020
文献标志码:
A
摘要:
目的 探讨心房颤动患者外周血白细胞中长链非编码RNA（LncRNA）心肌梗死相关转录本（MIAT）表达水平与导管消融术后复发的关系。方法 选择2019年7月~2020年6月于安徽省立医院心内科住院的150例房颤患者为研究对象。采用实时定量PCR技术检测房颤患者外周血白细胞中LncRNA MIAT的表达水平。导管消融术后3个月内每月随访1次，根据随访是否复发分为复发组和未复发组。使用Logistic回归分析评估LncRNA MIAT表达水平与导管消融术后复发的关系。结果 共41例房颤患者复发，复发组LncRNA MIAT表达水平为（2.13±0.67），高于未复发组的（1.70±0.69），差异有统计学意义（P＜0.05）；Logistic回归分析显示LncRNA MIAT表达水平是复发的独立危险因素（P＜0.05）。结论 LncRNA MIAT在心房颤动术后复发患者外周血白细胞中呈现高表达，是导管消融术后复发独立危险因素。
Abstract:
Objective To investigate the relationship between the expression of long-chain non-coding RNA (LncRNA) myocardial infarction-associated transcript (MIAT) and recurrence after catheter ablation in peripheral blood leukocytes of patients with atrial fibrillation.Methods 150 patients with atrial fibrillation who were hospitalized in the Department of Cardiovascular Medicine of Anhui Provincial Hospital from July 2019 to June 2020 were selected as the research objects.Real-time quantitative PCR technology was used to detect the expression level of LncRNA MIAT in peripheral blood leukocytes of patients with atrial fibrillation. Follow-up was conducted once a month within 3 months after catheter ablation and were divided into recurrence group and non recurrence group. Logistic regression analysis was used to evaluate the relationship between LncRNA MIAT expression and recurrence after catheter ablation.Results A total of 41 patients with atrial fibrillation relapsed. The expression level of LncRNA MIAT in the relapsed group was (2.13±0.67), which was higher than that of the non-relapsed group (1.70±0.69),the difference was statistically significant (P＜0.05);Logistic regression analysis showed that the expression level of LncRNA MIAT was an independent risk factor for recurrence (P＜0.05).Conclusion LncRNA MIAT is highly expressed in peripheral blood leukocytes in patients with recurrence after atrial fibrillation, and is an independent risk factor for recurrence after catheter ablation.

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更新日期/Last Update: 1900-01-01