[1]史浩明,吴庆琛.ⅠB期肺腺癌术后复发转移因素研究[J].医学信息,2021,34(04):92-95.[doi:10.3969/j.issn.1006-1959.2021.04.024]
 SHI Hao-ming,WU Qing-chen.Study on the Factors of Postoperative Recurrence and Metastasis of Stage ⅠB Lung Adenocarcinoma[J].Medical Information,2021,34(04):92-95.[doi:10.3969/j.issn.1006-1959.2021.04.024]
点击复制

ⅠB期肺腺癌术后复发转移因素研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
92-95
栏目:
论著
出版日期:
2021-02-15

文章信息/Info

Title:
Study on the Factors of Postoperative Recurrence and Metastasis of Stage ⅠB Lung Adenocarcinoma
文章编号:
1006-1959(2021)04-0092-04
作者:
史浩明吴庆琛
(重庆医科大学附属第一医院胸心外科,重庆 400016)
Author(s):
SHI Hao-mingWU Qing-chen
(Department of Thoracic and Cardiac Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
关键词:
ⅠB期肺腺癌复发转移病理类型Ki-67
Keywords:
Stage IB lung adenocarcinomaRecurrenceMetastasisPathological typeKi-67
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2021.04.024
文献标志码:
A
摘要:
目的 探究接受手术治疗的ⅠB期肺腺癌患者术后复发转移的危险因素。方法 回顾性分析2016年1月~12月于我院行手术治疗的97例ⅠB期肺腺癌患者的临床及病理资料,根据随访结果将患者分为复发转移组及无复发转移组,根据Kaplan-Meier法绘制生存曲线,通过Cox单因素及多因素分析探讨患者术后复发转移的影响因素。结果 97例患者中有25例复发,复发率约25.77%,其中局部复发15例(60.00%),远处转移10例(40.00%)。单因素分析显示,糖尿病史、肿瘤病理类型为实性/微乳头及Ki-67≥10%是影响患者术后复发的因素;多因素分析显示,病理类型为实性/微乳头(HR:2.505,95%CI:1.117~5.618)及Ki-67≥10%(HR:4.507,95%CI:1.859~10.925)是为影响ⅠB期肺腺癌患者术后复发转移的独立危险因素。结论 病理类型为实性/微乳头及Ki-67高表达的ⅠB期肺腺癌患者术后复发及转移的风险较高,应考虑给予一定的辅助治疗以降低复发几率。
Abstract:
Objective To explore the risk factors of postoperative recurrence and metastasis in patients with stage IB lung adenocarcinoma undergoing surgical treatment.Methods The clinical and pathological data of 97 patients with stage IB lung adenocarcinoma who underwent surgical treatment in our hospital from January to December 2016 were retrospectively analyzed. According to the follow-up results, the patients were divided into recurrence and metastasis group and non-recurrence and metastasis group.According to the Kaplan-Meier method, the survival curve was drawn, and the influencing factors of postoperative recurrence and metastasis were explored through Cox univariate and multivariate analysis.Results 25 of the 97 patients had recurrence, the recurrence rate was about 25.77%, of which 15 cases had local recurrence (60.00%) and 10 cases had distant metastasis (40.00%).Univariate analysis showed that diabetes history, tumor pathological type solid/micropapillary, and Ki-67≥10% were factors affecting postoperative recurrence;Multivariate analysis showed that the pathological type was solid/micropapillary (HR: 2.505, 95%CI: 1.117-5.618) and Ki-67≥10% (HR: 4.507, 95%CI: 1.859-10.925) were Independent risk factors for postoperative recurrence and metastasis in patients with advanced lung adenocarcinoma.Conclusion Patients with stage IB lung adenocarcinoma with solid/micropapillary and Ki-67 high expression have a higher risk of recurrence and metastasis after surgery. Adjuvant treatment should be considered to reduce the chance of recurrence.

参考文献/References:

[1]Siegel RL,Miller KD,Jemal A.Cancer statistics,2019[J].CA:A Cancer Journal for Clinicians,2019,69(1):7-34. [2]Koning HD,Der Aalst CV,Haaf KT,et al.PL02.05 Effects of Volume CT Lung Cancer Screening:Mortality Results of the NELSON Randomised-Controlled Population Based Trial[J].Journal of Thoracic Oncology,2018,13(10):S185. [3]Detterbeck FC,Boffa DJ,Kim AW,et al.The Eighth Edition Lung Cancer Stage Classification[J].Chest,2017,151(1):193-203. [4]Park HJ,Park HS,Cha YJ,et al.Efficacy of adjuvant chemotherapy for completely resected stage IB non-small cell lung cancer:a retrospective study[J].Journal of Thoracic Disease,2018,10(4):2279-2287. [5]Moon Y,Choi SY,Park JK,et al.Prognostic factors in stage IB non-small cell lung cancer according to the 8th edition of the TNM staging system after curative resection[J].Journal of Thoracic Disease,2019,11(12):5352-5361. [6]Kim IH,Lee IH,Lee JE,et al.Prognostic Impact of Multiple Clinicopathologic Risk Factors and c-MET Overexpression in Patients Who Have Undergone Resection of Stage IB Non-Small-Cell Lung Cancer[J].Clinical Lung Cancer,2016,17(5):e31-e43. [7]Li X,Zhang C,Sun Z,et al.Propensity-matched analysis of adjuvant chemotherapy for completely resected Stage IB non-small-cell lung cancer patients[J].Lung Cancer,2019(133):75-82. [8]Ning Y,Zheng H,Zhan Y,et al.Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer[J].Journal of Experimental&Clinical Cancer Research,2020,39(1):162. [9]Qian F,Yang W,Wang R,et al.Prognostic significance and adjuvant chemotherapy survival benefits of a solid or micropapillary pattern in patients with resected stage IB lung adenocarcinoma[J].The Journal of Thoracic and Cardiovascular Surgery,2018,155(3):1227-1235. [10]Tsao MS,Marguet S,Le Teuff G,et al.Brambilla.Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection[J].Journal of Clinical Oncology,2015,33(30):3439-3446. [11]李科,曹永清,肖劲军,等.TTF-1、NapsinA和Ki-67在非小细胞肺癌中的表达及意义[J].河北医药,2018,40(5):735-738. [12]代婉清,周英欣,李金金,等.肺癌患者血清癌胚抗原和Ki-67对预测预后的作用[J].中华实用诊断与治疗杂志,2020,34(2):177-180. [13]Wei DM,Chen WJ,Meng RM,et al.Augmented expression of Ki-67 is correlated with clinicopathological characteristics and prognosis for lung cancer patients:an up-dated systematic review and meta-analysis with 108 studies and 14,732 patients[J].Respiratory Research,2018,19(1):150. [14]Zhu WY,Hu XF,Fang KX,et al.Prognostic value of mutant p53,Ki-67,and TTF-1 and their correlation with EGFR mutation in patients with non-small cell lung cancer[J].Histology and Histopathology,2019,34(11):1269-1278. [15]Koichi K,Hiroko W,Hiroichi I,et al.Survival of patients with lung cancer and diabetes mellitus[J].Molecular and Clinical Oncology,2017,6(6):907-910. [16]Deng HY,Zheng X,Zha P,et al.Diabetes mellitus and survival of non‐small cell lung cancer patients after surgery:A comprehensive systematic review and meta‐analysis[J].Thoracic Cancer,2019,10(3):571-578. [17]Cao S,Teng J,Xu J,et al.Value of adjuvant chemotherapy in patients with resected stage IB solid predominant and solid non-predominant lung adenocarcinoma[J].Thoracic Cancer,2019,10(2):249-255. [18]Luo J,Huang Q,Wang R,et al.Prognostic and predictive value of the novel classification of lung adenocarcinoma in patients with stage IB[J].Journal of Cancer Research and Clinical Oncology,2016,142(9):2031-2040.

相似文献/References:

[1]倪航航,梁志宏,刘书强,等.对Ⅲ度痔两种手术方式治疗效果的评价[J].医学信息,2018,31(11):107.[doi:10.3969/j.issn.1006-1959.2018.11.033]
 NI Hang-hang,LIANG Zhi-hong,LIU Shu-qiang,et al.Evaluation of the Effect of Two Kinds of Surgical Treatment for Ⅲ Degree Hemorrhoids[J].Medical Information,2018,31(04):107.[doi:10.3969/j.issn.1006-1959.2018.11.033]
[2]陶 洪,孙国平.非小细胞肺癌根治术后复发及进展影响因素的回顾性分析[J].医学信息,2018,31(12):61.[doi:10.3969/j.issn.1006-1959.2018.12.019]
 TAO Hong,SUN Guo-ping.Retrospective Analysis of Factors Influencing Recurrence and Progression after Radical Resection of Non-small Cell Lung Cancer[J].Medical Information,2018,31(04):61.[doi:10.3969/j.issn.1006-1959.2018.12.019]
[3]史世华,马天洪,山家玥,等.中药汤剂联合西药口服治疗痛风性关节炎预后的Meta分析[J].医学信息,2018,31(19):131.[doi:10.3969/j.issn.1006-1959.2018.19.039]
 SHI Shi-hua,MA Tian-hong,SHAN Jia-yue,et al.Meta-analysis of the Prognosis of Oral Traditional Chinese Medicine Decoction Combined with Western Medicine in the Treatment of Gouty Arthritis[J].Medical Information,2018,31(04):131.[doi:10.3969/j.issn.1006-1959.2018.19.039]
[4]刘 然.头颅MRI-DWI病灶数量及部位对脑梗死复发预测意义[J].医学信息,2018,31(22):172.[doi:10.3969/j.issn.1006-1959.2018.22.052]
 LIU Ran.The Significance of the Number and Location of MRI-DWI Lesions in Predicting the Recurrence of Cerebral Infarction[J].Medical Information,2018,31(04):172.[doi:10.3969/j.issn.1006-1959.2018.22.052]
[5]罗文广,童 敏,张克春,等.修正性鼻内镜手术治疗慢性鼻-鼻窦炎鼻内镜术后复发的处理措施研究[J].医学信息,2018,31(23):183.[doi:10.3969/j.issn.1006-1959.2018.23.054]
 LUO Wen-guang,TONG Min,ZHANG Ke-chun,et al.Treatment of Recurrence of Chronic Rhino-sinusitisafter Endoscopic Surgery by Modified Endoscopic Sinus Surgery[J].Medical Information,2018,31(04):183.[doi:10.3969/j.issn.1006-1959.2018.23.054]
[6]高正添,贾天阳,常成兵,等.椎间孔镜治疗退行性腰椎管狭窄症疗效分析及术后复发因素分析[J].医学信息,2019,32(01):115.[doi:10.3969/j.issn.1006-1959.2019.01.035]
 GAO Zheng-tian,JIA Tian-yang,CHANG Cheng-bing,et al.Analysis of the Efficacy of Intervertebral Foramen in the Treatment of Degenerative Lumbar Spinal Stenosis and Analysis of Postoperative Recurrence Factors[J].Medical Information,2019,32(04):115.[doi:10.3969/j.issn.1006-1959.2019.01.035]
[7]石 磊.改良性保乳保腋窝手术与传统保乳手术对 T1期乳腺癌患者复发的影响[J].医学信息,2019,32(11):119.[doi:10.3969/j.issn.1006-1959.2019.11.034]
 SHI Lei.Effect of Modified Breast-preserving Axillary Surgery and Traditional Breast-conserving Surgery on Recurrence of T1 Breast Cancer Patients[J].Medical Information,2019,32(04):119.[doi:10.3969/j.issn.1006-1959.2019.11.034]
[8]白梦箫,刘 晨.子宫内膜息肉的诊疗现状[J].医学信息,2019,32(20):45.[doi:10.3969/j.issn.1006-1959.2019.20.013]
 BAI Meng-xiao,LIU Chen.Current Status of Diagnosis and Treatment of Endometrial Polyps[J].Medical Information,2019,32(04):45.[doi:10.3969/j.issn.1006-1959.2019.20.013]
[9]肖 戈,尹 杰,林靖波,等.经皮肾镜碎石取石术的疗效及术后复发的危险因素分析[J].医学信息,2019,32(21):98.[doi:10.3969/j.issn.1006-1959.2019.21.030]
 XIAO Ge,YIN Jie,LIN Jing-bo,et al.Therapeutic Effect of Percutaneous Nephrolithotomy and Risk Factors for Postoperative Recurrence of Stones[J].Medical Information,2019,32(04):98.[doi:10.3969/j.issn.1006-1959.2019.21.030]
[10]董连红.心理护理和健康护理在真菌性阴道炎患者中的应用[J].医学信息,2019,32(23):183.[doi:10.3969/j.issn.1006-1959.2019.23.060]
 DONG Lian-hong.Application of Psychological Care and Health Care in Patients with Fungal Vaginitis[J].Medical Information,2019,32(04):183.[doi:10.3969/j.issn.1006-1959.2019.23.060]

更新日期/Last Update: 1900-01-01