[1]葛菁茹,朱静雅,苏日新,等.以肺转移为首发表现的结肠癌预后分析[J].医学信息,2021,34(04):96-98.[doi:10.3969/j.issn.1006-1959.2021.04.025]
　GE Jing-ru,ZHU Jing-ya,SU Ri-xin,et al.Prognostic Analysis of Colon Cancer with Lung Metastasis as the First Manifestation[J].Medical Information,2021,34(04):96-98.[doi:10.3969/j.issn.1006-1959.2021.04.025]
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以肺转移为首发表现的结肠癌预后分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
96-98
栏目:
论著
出版日期:
2021-02-15

文章信息/Info

Title:
Prognostic Analysis of Colon Cancer with Lung Metastasis as the First Manifestation
文章编号:
1006-1959（2021）04-0096-03
作者:
葛菁茹; 朱静雅; 苏日新; 等
(1.安徽医科大学附属省立医院肿瘤内科，安徽 合肥 230000； 2.中国科学技术大学附属第一医院西区/安徽省肿瘤医院肿瘤内科，安徽 合肥 230000)
Author(s):
GE Jing-ru; ZHU Jing-ya; SU Ri-xin; et al.
(1.Department of Medical Oncology,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230000,Anhui,China; 2.Department of Medical Oncology,West District,the First Affiliated Hospital of University of Science and Technology of China Anhu
关键词:
结肠癌; 肺转移; 无病生存期
Keywords:
Colon cancer; Lung metastasis; Disease-free survival
分类号:
R735.3+5
DOI:
10.3969/j.issn.1006-1959.2021.04.025
文献标志码:
A
摘要:
目的 分析以肺转移为首发表现的结肠癌患者的预后的因素。方法 回顾性分析2011年10月~2020年4月安徽医科大学附属省立医院确诊的以肺转移为首发表现的47例结肠癌患者资料，采用Kaplan-Meier法分析临床病理特征（年龄、性别、原发灶位置、N分期、分化程度、有无肠梗阻、肺部病灶位置、有无肝转移、肿瘤标志物CEA及CA199）与无疾病生存期（DFS）的关系，并采用多因素Cox模型分析影响患者DFS的独立因素。结果 全组患者中位DFS为16.5个月。单因素分析显示，肺部病灶位置及有无肝转移与DFS有关（P＜0.05）；而年龄、性别、原发灶位置、N分期、分化程度、有无肠梗阻、肿瘤标志物CEA及CA199与DFS无相关性（P＞0.05）。多因素分析显示，肺部病灶位置、有无肝转移为影响DFS的独立因素。结论 在以肺转移为首发表现的结肠癌中肺部病灶位置、有无肝转移可能为影响疾病进展的独立预后因素。
Abstract:
Objective To analyze the prognostic factors of colon cancer patients with lung metastasis as the first manifestation.Methods A retrospective analysis of the data of 47 patients with colon cancer diagnosed in Anhui Provincial Hospital Affiliated to Anhui Medical University from October 2011 to April 2020 with lung metastasis as the first manifestation.The Kaplan-Meier method was used to analyze clinicopathological characteristics (age, gender, location of primary tumor, N stage, degree of differentiation, intestinal obstruction, location of lung lesions, liver metastasis, tumor markers CEA and CA199) and disease-free relationship between survival time (DFS), and the use of a multivariate Cox model to analyze independent factors that affect disease-free survival (DFS) of patients.Results The median DFS of all patients was 16.5 months. Univariate analysis showed that the location of lung lesions and the presence or absence of liver metastasis were related to DFS (P<0.05);There was no correlation between age, gender, location of primary tumor, N stage, degree of differentiation, intestinal obstruction, tumor markers CEA and CA199 and DFS (P>0.05).Multivariate analysis showed that the location of lung lesions and the presence or absence of liver metastasis were the influence Independent factors of DFS.Conclusion In colon cancer with lung metastasis as the first manifestation, the location of lung lesions and the presence or absence of liver metastasis may be independent prognostic factors affecting disease progression.

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