[1]单 昕,艾迎春.白细胞介素-18与疾病的研究[J].医学信息,2021,34(07):53-55.[doi:10.3969/j.issn.1006-1959.2021.07.015]
 SHAN Xin,AI Ying-chun.Research of Interleukin-18 and Diseases[J].Medical Information,2021,34(07):53-55.[doi:10.3969/j.issn.1006-1959.2021.07.015]
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白细胞介素-18与疾病的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年07期
页码:
53-55
栏目:
综述
出版日期:
2021-04-01

文章信息/Info

Title:
Research of Interleukin-18 and Diseases
文章编号:
1006-1959(2021)07-0053-03
作者:
单 昕艾迎春
(佳木斯大学附属第一医院消化二病区,黑龙江 佳木斯 154002)
Author(s):
SHAN XinAI Ying-chun
(Digestive Second Ward,the First Affiliated Hospital of Jiamusi University,Jiamusi 154002,Heilongjiang,China)
关键词:
IL-18促炎因子IFN-γ哮喘急性胰腺炎
Keywords:
IL-18Pro-inflammatory factorIFN-γAsthmaAcute pancreatitis
分类号:
R392
DOI:
10.3969/j.issn.1006-1959.2021.07.015
文献标志码:
A
摘要:
白细胞介素-18(IL-18)是IL-1细胞因子家族的成员,最初发现IL-18是被增强的抗CD3抗体刺激的Th1细胞产生的细胞因子IFN-γ。虽然IL-1和IL-18使用相同的信号通路与不同的受体结合,但具有不同的生物学特性。IL-18可以由多种免疫细胞及非免疫细胞产生,并通过与不同类型细胞上表达的特定受体结合而展示出独特的功能,在宿主抵御感染中起着至关重要的作用,其也是一种强效的促炎性细胞因子,在多种炎症条件下都具有病理生理作用,与多种疾病的发生、发展相关联,现将与IL-18有相关性的疾病研究进展进行综述,旨在阐明IL-18参与各种疾病的作用机制及其在疾病的诊断、严重程度、活动性、预后评估中的价值,以及是否可以作为与其相关疾病临床诊断的一种生物标记物,是否可以通过阻断IL-18的产生,抵消其在疾病中的生物学效应来减缓疾病的发展,帮助疾病的治疗。
Abstract:
IL-18 is a member of the IL-1 cytokine family. IL-18 was originally discovered to be the cytokine IFN-γ produced by Th1 cells stimulated by enhanced anti-CD3 antibodies.Although IL-1 and IL-18 use the same signaling pathway to bind to different receptors, they have different biological properties.IL-18 can be produced by a variety of immune cells and non-immune cells, and displays unique functions by binding to specific receptors expressed on different types of cells, and plays a vital role in the host’s defense against infection.It is also a potent pro-inflammatory cytokine, which has pathophysiological effects under a variety of inflammatory conditions, and is associated with the occurrence and development of a variety of diseases.The research progress of diseases related to IL-18 is now reviewed, aiming to clarify the mechanism of action of IL-18 in various diseases and its value in the diagnosis, severity, activity, prognosis of the disease, and whether can it be used as a biomarker for the clinical diagnosis of related diseases, whether it can slow down the development of the disease and help the treatment of the disease by blocking the production of IL-18 and offsetting its biological effect in the disease.

参考文献/References:

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更新日期/Last Update: 1900-01-01