[1]孙瑞希,付 萍.抗MDA5抗体相关性皮肌炎的临床、实验室表现及治疗研究[J].医学信息,2021,34(08):31-35.[doi:10.3969/j.issn.1006-1959.2021.08.009]
 SUN Rui-xi,FU Ping.Clinical and Laboratory Manifestations and Treatment of Anti-MDA5 Antibody-related Dermatomyositis[J].Medical Information,2021,34(08):31-35.[doi:10.3969/j.issn.1006-1959.2021.08.009]
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抗MDA5抗体相关性皮肌炎的临床、实验室表现及治疗研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年08期
页码:
31-35
栏目:
综述
出版日期:
2021-04-15

文章信息/Info

Title:
Clinical and Laboratory Manifestations and Treatment of Anti-MDA5 Antibody-related Dermatomyositis
文章编号:
1006-1959(2021)08-0031-05
作者:
孙瑞希付 萍
(昆明医科大学第二附属医院风湿免疫科,云南 昆明 650000)
Author(s):
SUN Rui-xiFU Ping
(Department of Rheumatology and Immunology,the Second Affiliated Hospital of Kunming Medical University, Kunming 650000,Yunnan,China)
关键词:
抗黑色素瘤分化相关基因 5抗体皮肌炎肺间质病变
Keywords:
Anti-melanoma differentiation-related gene 5 antibodyDermatomyositisPulmonary interstitial lesions
分类号:
R593.26
DOI:
10.3969/j.issn.1006-1959.2021.08.009
文献标志码:
A
摘要:
抗黑色素瘤分化相关基因5(MDA5)抗体是一种首先发现于临床无肌病性皮肌炎(CADM)的自身抗体,常见于皮肌炎(DM)患者,临床表现比较特别。MDA5在亚裔人群中与快速进展性肺间质病变(RPILD)高度相关,患者病情往往较重,常规免疫治疗效果不佳,预后极差,死亡率较高,治疗上无统一标准。本文主要对抗MDA5抗体及其相关性皮肌炎的临床表现、实验室指标、治疗进展进行综述,以期提高临床对该病的认识。
Abstract:
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is an autoantibody first discovered in clinical amyopathy dermatomyositis (CADM). It is common in patients with dermatomyositis (DM) and has a special clinical manifestation.MDA5 is highly correlated with rapidly progressive pulmonary interstitial disease (RPILD) in the Asian population. Patients are often in severe disease, with poor results of conventional immunotherapy, extremely poor prognosis, and high mortality. There is no uniform standard for treatment.This article mainly reviews the clinical manifestations, laboratory indicators, and treatment progress of anti-MDA5 antibodies and related dermatomyositis, in order to improve clinical understanding of the disease.

参考文献/References:

[1]Long K,Danoff SK.Interstitial Lung Disease in Polymyositis and Dermatomyositis[J].Clin Chest Med,2019,40(3):561-572. [2]Sun Y,Liu Y,Yan B,et al.Interstitial lung disease in clinically amyopathic dermatomyositis(CADM)patients:a retrospective study of 41 Chinese Han patients[J].Rheumatology International,2013,33(5):1295-1302. [3]Sato S,Hirakata M,Kuwana M,et al.Autoantibodies to a 140-kd polypeptide,CADM-140,in Japanese patients with clinically amyopathic dermatomyositis[J].Arthritis&Rheumatism,2010,52(5):1571-1576. [4]Sato S,Hoshino K,Satoh T,et al.RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis:Association with rapidly progressive interstitial lung disease[J].Arthritis Rheum,2009,60(7):2193-2200. [5]程玉强.鸡MDA5-STING-IFN-β抗病毒天然免疫通路的发现及其信号转导机制[D].上海交通大学,2016. [6]曹华,夏群力,亢延卿,等.抗黑素瘤分化相关基因5抗体评价皮肌炎/临床无肌病性皮肌炎合并肺间质病变的病情及预后的研究[J].中华风湿病学杂志,2014,18(5):329-331. [7]Takada T,Ohashi K,Hayashi M,et al.Role of IL-15 in interstitial lung diseases in amyopathic dermatomyositis with anti-MDA-5 antibody[J].Respiratory Medicine,2018(141):7-13. [8]Louise E,Michelle KJ,Sevim BH,et al.Dysfunction of endothelial progenitor cells is associated with the type I IFN pathway in patients with polymyositis and dermatomyositis[J].Rheumatology,2016,55(11):1987-1992. [9]Allenbach Y,Leroux G,Suárez-Calvet X,et al.Dermatomyositis With or Without Anti-Melanoma Differentiation-Associated Gene 5 Antibodies:Common Interferon Signature but Distinct NOS2 Expression[J].Am J Pathol,2016,186(3):691-700. [10]Wong V,Ho SO,Yip R.Myositis-specific autoantibodies and their clinical associations in Idiopathic Inflammatory Myopathies[J].Acta Neurol Scand,2021,143(2):131-139. [11]Fiorentino D,Chung L,Zwerner J,et al.The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5(CADM-140):a retrospective study[J].Journal of the American Academy of Dermatology,2011,65(1):25-34. [12]李梦圆,陈斌锋.抗MDA5阳性的特发性炎性肌病的临床特征[J].广东医学,2020,7(41):683-687. [13]陈芳,王冬雪.血清抗黑色素瘤分化相关基因抗体检测在多发性肌炎/皮肌炎患者中的意义[J].中华风湿病学杂志,2012,1(16):13-18. [14]陈志涵,高飞.皮肌炎并发纵隔气肿的临床特点[J].中华临床免疫和变态反应杂志,2018,5(12):532-536. [15]Kim Y,Sykes AJ,Tugnet N,et al.Digital ulcerations in anti-MDA5 dermatomyositis:Complete resolution following treatment with cyclophosphamide[J].Australasian Journal of Dermatology,2020,61(2):e251-e252. [16]郭子维,王燕.皮肌炎合并纵隔气肿患者的临床特点及血清学特征[J].中华风湿病学杂志,2015,9(19):592-597. [17]Liao AP,Salajegheh M,Nazareno R,et al.Interferon β is associated with type 1 interferon-inducible gene expression in dermatomyositis[J].Annals of the Rheumatic Diseases,2011,70(5):831. [18]Fujiki Y,Kotani T,Isoda K,et al.Evaluation of clinical prognostic factors for interstitial pneumonia in anti-MDA5 antibody-positive dermatomyositis patients[J].Modern Rheumatology,2017,28(1):1-8. [19]Gono T,Kawaguchi Y,Ozeki E,et al.Serum ferritin correlates with activity of anti-MDA5 antibody-associated acute interstitial lung disease as a complication of dermatomyositis[J].Japanese Journal of Rheumatology,2011,21(2):223-227. [20]Pacot L,Pouchot J,Prost ND,et al.Interstitial Lung Disease-Complicated Anti-MDA5 Antibody in Clinically Amyopathic Dermatomyositis Patients:Report of Two Cases With Distinct Clinical Features[J].Frontiers in Medicine,2020(7):77. [21]Ye Y,Fu Q,Wang R,et al.Serum KL‐6 level is a prognostic marker in patients with anti‐MDA5 antibody‐positive dermatomyositis associated with interstitial lung disease[J].Journal of Clinical Laboratory Analysis,2019,33(8):e22978. [22]Horai Y,Koga T,Fujikawa K,et al.Serum interferon-α is a useful biomarker in patients with anti-melanoma differentiation-associated gene 5(MDA5)antibody-positive dermatomyositis[J].Modern Rheumatology,2015,25(1):85-89. [23]Lam SC,Yuen H.Unilateral Eyelid Swelling as a Sign of Antimelanoma Differentiation-Associated Gene 5(Anti-MDA5)-Antibody-Positive Dermatomyositis[J].Ophthalmic Plastic&Reconstructive Surgery,2018,34(6):e209-e211. [24]Cafardi JM,Sami N.Intravenous Immune Globulin in Amyopathic Dermatomyositis-Report of Two Cases and Review of the Literature[J].Open Rheumatology Journal,2015,9(1):77-81. [25]Endo Y,Koga T,Suzuki T,et al.Successful treatment of plasma exchange for rapidly progressive interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis:A case report[J].Medicine,2018,97(15):e0436. [26]Yamagata A,Arita M,Tanaka A,et al.Therapeutic plasma exchange for clinically amyopathic dermatomyositis (CADM) associated with rapidly progressive interstitial pneumonia[J].J Clin Apher,2020,35(5):435-443. [27]Kato M,Ikeda K,Kageyama T,et al.Successful Treatment for Refractory Interstitial Lung Disease and Pneumomediastinum With Multidisciplinary Therapy Including Tofacitinib in a Patient With Anti-MDA5 Antibody-Positive Dermatomyositis[J].Journal of Clinical Rheumatology,2020,publish ahead of print. [28]Takatani A,Koga T,Fujita Y,et al.Efficacy of tofacitinib for slowly progressive interstitial lung disease in a patient with anti-MDA5 antibody-positive dermatomyositis[J].Clinical Immunology,2020(215):108451. [29]Koichi Y,Aya Y,Megumi U,et al.A case of anti-MDA5-positive rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis ameliorated by rituximab,in addition to standard immunosuppressive treatment[J].Japanese Journal of Rheumatology,2017,27(3):536-540. [30]Moghadam-Kia S,Oddis CV,Aggarwal R.Modern Therapies for Idiopathic Inflammatory Myopathies(IIMs):Role of Biologics[J].Clinical Reviews in Allergy&Immunology,2016,52(1):1-7.

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更新日期/Last Update: 1900-01-01