[1]郑鑫辉,崔慧丽,邵 进,等.克罗恩病患者骨质疏松症的影响因素分析[J].医学信息,2021,34(08):68-71,80.[doi:10.3969/j.issn.1006-1959.2021.08.018]
 ZHENG Xin-hui,CUI Hui-li,SHAO Jin,et al.Analysis of Influencing Factors of Osteoporosis in Patients with Crohn’s Disease[J].Medical Information,2021,34(08):68-71,80.[doi:10.3969/j.issn.1006-1959.2021.08.018]
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克罗恩病患者骨质疏松症的影响因素分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年08期
页码:
68-71,80
栏目:
论著
出版日期:
2021-04-15

文章信息/Info

Title:
Analysis of Influencing Factors of Osteoporosis in Patients with Crohn’s Disease
文章编号:
1006-1959(2021)08-0068-05
作者:
郑鑫辉崔慧丽邵 进
(1.宁夏医科大学研究生院,宁夏 银川 750004; 2.郑州大学第一附属医院神经内科,河南 郑州 450000; 3.上海市浦东新区公利医院骨科,上海 200135)
Author(s):
ZHENG Xin-huiCUI Hui-liSHAO Jinet al.
(1.Graduate School of Ningxia Medical University,Yinchuan 750004,Ningxia,China; 2.Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan,China; 3.Department of Orthopedics,Gongli Hospital,Pudong New Area,Shanghai 200135,China)
关键词:
骨质疏松克罗恩病粪钙卫蛋白
Keywords:
OsteoporosisCrohn’s diseaseFecal calprotectin
分类号:
R681
DOI:
10.3969/j.issn.1006-1959.2021.08.018
文献标志码:
A
摘要:
目的 探讨克罗恩病(CD)患者骨质疏松的潜在影响因素。方法 选取2019年1月~2020年10月上海市浦东新区公利医院诊断的60例CD患者设为CD组,另选取同期门诊就诊的20名体检健康人员作为健康对照组,均进行骨密度(BMD)测量、粪便和血液样品的收集,其中6例CD患者、健康对照组行肠镜活检,比较两组BMD、粪钙卫蛋白(FC)、血清zonulin以及炎性因子TNF-α水平,分析CD患者BMD与FC、血清zonulin、TNF-α的相关性;并比较健康对照组和CD组结肠组织中ZO-1表达及荧光强度情况。结果 CD组BMD低于对照组,FC、血清zonulin、TNF-α高于对照组,差异有统计学意义(P<0.05);线性相关分析显示,BMD与FC、血清zonulin、TNF-α呈负相关(r=-0.259、-0.362、-0.325,P<0.05)。肠道免疫组化和免疫荧光显示,CD患者肠道屏障明显受损。结论 FC、血清zonulin的水平检测对CD患者肠道炎症、肠通透性评估具有一定价值,且克罗恩病诱导的BMD改变证实与肠道炎症改变、肠道通透性增加及血清TNF-α具有相关性。肠道炎症、肠道屏障破坏可能是骨质疏松症病情发展的重要机制,通过减少肠道炎症,抑制肠道通透性破坏来缓解骨质疏松的进展可能成为CD的治疗方向。
Abstract:
Objective To explore the potential influencing factors of osteoporosis in patients with Crohn’s disease (CD).Methods A total of 60 CD patients diagnosed by Gongli Hospital in Pudong New Area, Shanghai from January 2019 to October 2020 were selected as the CD group, and 20 healthy people who had undergone physical examinations in outpatient clinics during the same period were selected as the healthy control group.Bone mineral density (BMD) measurement, stool and blood samples were collected. Among them, 6 CD patients and healthy controls underwent colonoscopy biopsy. The two groups were compared with BMD, fecal calprotectin (FC), serum zonulin and inflammatory factor TNF-α level, analyze the correlation between BMD and FC, serum zonulin and TNF-α in CD patients; compare the expression and fluorescence intensity of ZO-1 in colon tissues of healthy control group and CD group.Results The BMD of the CD group was lower than that of the control group, and the FC, serum zonulin and TNF-α were higher than those of the control group, the difference was statistically significant (P<0.05);Linear correlation analysis showed that BMD was negatively correlated with FC, serum zonulin, and TNF-α(r=-0.259,-0.362,-0.325,P<0.05).Intestinal immunohistochemistry and immunofluorescence showed that the intestinal barrier of patients with CD was significantly damaged.Conclusion The detection of FC and serum zonulin levels has certain value for the assessment of intestinal inflammation and intestinal permeability in patients with CD. The changes in BMD induced by Crohn’s disease are confirmed to be related to intestinal inflammation, increased intestinal permeability and serum TNF-αis relevant.Intestinal inflammation and destruction of the intestinal barrier may be an important mechanism for the development of osteoporosis. It may become the treatment direction of CD to alleviate the progress of osteoporosis by reducing intestinal inflammation and inhibiting the destruction of intestinal permeability.

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更新日期/Last Update: 1900-01-01