[1]章丽萍,宗洪芳,高菁遥,等.不同频次泼尼松治疗亚急性甲状腺炎的效果[J].医学信息,2021,34(10):167-169.[doi:10.3969/j.issn.1006-1959.2021.10.049]
　ZHANG Li-ping,ZONG Hong-fang,GAO Jing-yao,et al.The Effect of Prednisone with Different Frequency in the Treatment of Subacute Thyroiditis[J].Medical Information,2021,34(10):167-169.[doi:10.3969/j.issn.1006-1959.2021.10.049]
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不同频次泼尼松治疗亚急性甲状腺炎的效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年10期
页码:
167-169
栏目:
药物与临床
出版日期:
2021-05-15

文章信息/Info

Title:
The Effect of Prednisone with Different Frequency in the Treatment of Subacute Thyroiditis
文章编号:
1006-1959（2021）10-0167-03
作者:
章丽萍; 宗洪芳; 高菁遥; 等
（1.丰都县人民医院内分泌科，重庆 408200；2.丰都县疾控中心流行病学调查科，重庆 408200）
Author(s):
ZHANG Li-ping; ZONG Hong-fang; GAO Jing-yao; et al.
(1.Department of Endocrinology,Fengdu County People’s Hospital,Chongqing 408200,China;2.Department of Epidemiology,Fengdu County Center for Disease Control and Prevention,Chongqing 408200,China)
关键词:
亚急性甲状腺炎; 泼尼松; 甲状腺功能
Keywords:
Subacute thyroiditis; Prednisone; Thyroid function
分类号:
R581.4
DOI:
10.3969/j.issn.1006-1959.2021.10.049
文献标志码:
A
摘要:
目的 探讨相同剂量不同频次泼尼松治疗中重度亚急性甲状腺炎的疗效与服药依从性。方法 选取2014年1月~2019年8月我院就诊的中重度亚急性甲状腺炎102例作为研究对象，随机分为每日顿服治疗组（A组）和每日多次治疗组（B组），各51例。A组起始泼尼松30 mg/d晨起顿服，B组起始泼尼松30 mg/d并分3次服用，两组治疗1~2周后根据症状缓解情况逐渐减量，每周每日递减5 mg，总疗程6~8周，比较两组治疗效果、不良反应发生率、服药依从性。结果 两组退热时间、甲状腺疼痛消退时间、甲状腺肿消退时间、治疗总有效率及复发率比较，差异无统计学意义（P＞0.05）。两组胃部不适、情绪不稳、血糖升高及血压升高发生率率比较，差异无统计学意义（P＞0.05）；A组体重增加发生率低于B组，差异有统计学意义（P＜0.05）。A组Morisky问卷得分为（3.07±0.66）分，高于B组的（2.67±0.61）分，差异有统计学意义（t=3.178，P＜0.05）。结论 泼尼松每日顿服与每日多次治疗两种不同给药方案治疗中重度亚急性甲状腺炎临床疗效相同，每日顿服方案在体重增加副反应方面低于每日多次给药方案，且依从性优于每日多次给药方案。
Abstract:
Objective To investigate the efficacy and medication compliance of prednisone at the same dose and frequency in the treatment of moderate to severe subacute thyroiditis.Methods A total of 102 patients with moderate to severe subacute thyroiditis who were treated in our hospital from January 2014 to August 2019 were selected as the study objects, and they were randomly divided into a daily meal treatment group (group A) and a multiple daily treatment group (group B), 51 cases each.Group A starts with 30 mg/d prednisone in the morning, and group B starts with 30 mg/d prednisone and takes 3 times.After 1 to 2 weeks of treatment, the two groups were gradually reduced according to the relief of symptoms, with a daily decrease of 5 mg per week. The total course of treatment was 6 to 8 weeks. The treatment effects, incidence of adverse reactions, and medication compliance were compared between the two groups.Results There was no statistically significant difference between the two groups of fever time, thyroid pain resolution time, goiter resolution time, total effective rate of treatment and recurrence rate (P>0.05).There was no significant difference in the incidence of stomach discomfort, emotional instability, elevated blood sugar and elevated blood pressure between the two groups (P>0.05);The incidence of weight gain in group A was lower than that in group B,the difference was statistically significant (P<0.05).The score of the Morisky questionnaire in group A was (3.07±0.66), which was higher than that of group B (2.67±0.61),the difference was statistically significant (t=3.178, P＜0.05).Conclusion The clinical efficacy of two different dosing regimens in the treatment of moderate to severe subacute thyroiditis with prednisone daily and multiple daily treatments is the same. The daily meal regimen is lower than the side effects of multiple daily doses in terms of weight gain. The schedule, and compliance is better than multiple daily dosing schedules.

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更新日期/Last Update: 1900-01-01