参考文献/References:
[1]Eastell R,O’Neill TW,Hofbauer LC,et al.Postmenopausal osteoporosis[J].Nat Rev Dis Primers,2016(2):16069. [2]Gubatan J,Moss AC.Vitamin D in inflammatory bowel disease:more than just a supplement[J].Curr Opin Gastroenterol,2018,34(4):217-225. [3]Vernia P,Burrelli Scotti G,Dei Giudici A,et al.Inadequate sunlight exposure in patients with inflammatory bowel disease[J].J Dig Dis,2018,19(1):8-14. [4]Chedid VG,Kane SV.Bone Health in Patients With Inflammatory Bowel Diseases[J].J Clin Densitom,2020,23(2):182-189. [5]Lima CA,Lyra AC,Rocha R,et al.Risk factors for osteoporosis in inflammatory bowel disease patients[J].World J Gastrointest Pathophysiol,2015,6(4):210-218. [6]Oh HJ,Ryu KH,Park BJ,et al.Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease[J].J Bone Metab,2018,25(4):213-217. [7]Weisshof R,Chermesh I.Micronutrient deficiencies in inflammatory bowel disease[J].Curr Opin Clin Nutr Metab Care,2015,18(6):576-581. [8]Lopez-Munoz P,Beltran B,Saez-Gonzalez E,et al.Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients[J].Nutrients,2019,11(5):1059. [9]Garg M,Royce SG,Tikellis C,et al.The intestinal vitamin D receptor in inflammatory bowel disease:inverse correlation with inflammation but no relationship with circulating vitamin D status[J].Therap Adv Gastroenterol,2019(12):1756284818822566. [10]Zhang YG,Lu R,Xia Y,et al.Lack of Vitamin D Receptor Leads to Hyperfunction of Claudin-2 in Intestinal Inflammatory Responses[J].Inflamm Bowel Dis,2019,25(1):97-110. [11]Dimitrov V,White JH.Vitamin D signaling in intestinal innate immunity and homeostasis[J].Mol Cell Endocrinol,2017(453):68-78. [12]Tabatabaeizadeh SA,Tafazoli N,Ferns GA,et al.Vitamin D,the gut microbiome and inflammatory bowel disease[J].J Res Med Sci,2018(23):75. [13]Yamamoto E,Jorgensen TN.Immunological effects of vitamin D and their relations to autoimmunity[J].J Autoimmun,2019(100):7-16. [14]Olmedo-Martin RV,Gonzalez-Molero I,Olveira G,et al.Vitamin D in Inflammatory Bowel Disease:Biological,Clinical and Therapeutic Aspects[J].Curr Drug Metab,2019,20(5):390-398. [15]Battat R,Kopylov U,Byer J,et al.Vitamin B12 deficiency in inflammatory bowel disease:a prospective observational pilot study[J].Eur J Gastroenterol Hepatol,2017,29(12):1361-1367. [16]Huang S,Ma J,Zhu M,et al.Status of serum vitamin B12 and folate in patients with inflammatory bowel disease in China[J].Intest Res,2017,15(1):103-108. [17]Ghishan FK,Kiela PR.Vitamins and Minerals in Inflammatory Bowel Disease[J].Gastroenterol Clin North Am,2017,46(4):797-808. [18]Madanchi M,Fagagnini S,Fournier N,et al.The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort[J].Inflamm Bowel Dis,2018,24(8):1768-1779. [19]Martínez Gomez MJ,Melian Fernandez C,Romeo Donlo M.Nutricion en enfermedad in amatoria intestinal[Nutrition in inflammatory bowel disease][J].Nutr Hosp,2016,33(Suppl 4):348. [20]Battat R,Kopylov U,Szilagyi A,et al.Vitamin B12 deficiency in inflammatory bowel disease:prevalence,risk factors,evaluation,and management[J].Inflamm Bowel Dis,2014,20(6):1120-1128. [21]Becker J,Berger F,Schindlbeck KA,et al.Restless legs syndrome is a relevant comorbidity in patients with inflammatory bowel disease[J].Int J Colorectal Dis,2018,33(7):955-962. [22]Harb Z,Deckert V,Bressenot AM,et al.The deficit in folate and vitamin B12 triggers liver macrovesicular steatosis and inflammation in rats with dextran sodium sulfate-induced colitis[J].J Nutr Biochem,2020(84):108415. [23]Melhem H,Hansmannel F,Bressenot A,et al.Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress[J].Gut,2016,65(4):595-606. [24]Gao X,Li J,Chen M.Effect of Homocysteine on the Differentiation of CD4+T Cells into Th17 Cells[J].Dig Dis Sci,2018,63(12):3339-3347. [25]Lurz E,Horne RG,Maattanen P,et al.Vitamin B12 Deficiency Alters the Gut Microbiota in a Murine Model of Colitis[J].Front Nutr,2020(7):83. [26]Burr NE,Hull MA,Subramanian V.Folic Acid Supplementation May Reduce Colorectal Cancer Risk in Patients With Inflammatory Bowel Disease:A Systematic Review and Meta-Analysis[J].J Clin Gastroenterol,2017,51(3):247-253. [27]Bar-El Dadon S,Reifen R.Vitamin A and the epigenome[J].Crit Rev Food Sci Nutr,2017,57(11):2404-2411. [28]Fabisiak N,Fabisiak A,Watala C,et al.Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease:Systematic Review and Meta-Analysis[J].J Clin Gastroenterol,2017,51(10):878-889. [29]Pattanakitsakul P,Chongviriyaphan N,Pakakasama S,et al.Effect of vitamin A on intestinal mucosal injury in pediatric patients receiving hematopoietic stem cell transplantation and chemotherapy:a quasai-randomized trial[J].BMC Res Notes,2020,13(1):464. [30]He C,Deng J,Hu X,et al.Vitamin A inhibits the action of LPS on the intestinal epithelial barrier function and tight junction proteins[J].Food Funct,2019,10(2):1235-1242. [31]de Medeiros PHQS,Pinto DV,de Almeida JZ,et al.Modulation of Intestinal Immune and Barrier Functions by Vitamin A:Implications for Current Understanding of Malnutrition and Enteric Infections in Children[J].Nutrients,2018,10(9):1128. [32]Hong K,Zhang Y,Guo Y,et al.All-trans retinoic acid attenuates experimental colitis through inhibition of NF-κB signaling[J].Immunol Lett,2014,162(1 Pt A):34-40. [33]Cantorna MT,Snyder L,Arora J.Vitamin A and vitamin D regulate the microbial complexity, barrier function,and the mucosal immune responses to ensure intestinal homeostasis[J].Crit Rev Biochem Mol Biol,2019,54(2):184-192. [34]Bhattacharya N,Yuan R,Prestwood TR,et al.Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+)T Cell-Mediated Immunity in Colorectal Cancer[J].Immunity,2016,45(3):641-655. [35]Hao Z,Jin D,Chen X,et al.γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins[J].Blood,2021,137(4):533-543. [36]Villa JKD,Diaz MAN,Pizziolo VR,et al.Effect of vitamin K in bone metabolism and vascular calcification:A review of mechanisms of action and evidences[J].Crit Rev Food Sci Nutr,2017,57(18):3959-3970. [37]Dihingia A,Ozah D,Baruah PK,et al.Prophylactic role of vitamin K supplementation on vascular inflammation in type 2 diabetes by regulating the NF-κB/Nrf2 pathway via activating Gla proteins[J].Food Funct,2018,9(1):450-462. [38]Shiraishi E,Iijima H,Shinzaki S,et al.Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis[J].J Gastroenterol,2016,51(4):346-356. [39]Brnic D,Martinovic D,Zivkovic PM,et al.Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease[J].World J Gastroenterol,2020,26(32):4866-4877.