[1]茹银转,胡桂贞,陈云开,等.2018年~2020年某基层医院尿路感染的细菌分布及耐药状况调查[J].医学信息,2021,34(12):148-150.[doi:10.3969/j.issn.1006-1959.2021.12.040]
　RU Yin-zhuan,HU Gui-zhen,CHEN Yun-kai,et al.Survey of Bacterial Distribution and Drug Resistance of Urinary Tract Infections in a Primary Hospital from 2018 to 2020[J].Medical Information,2021,34(12):148-150.[doi:10.3969/j.issn.1006-1959.2021.12.040]
点击复制

2018年~2020年某基层医院尿路感染的细菌分布及耐药状况调查()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年12期
页码:
148-150
栏目:
调查分析
出版日期:
2021-06-15

文章信息/Info

Title:
Survey of Bacterial Distribution and Drug Resistance of Urinary Tract Infections in a Primary Hospital from 2018 to 2020
文章编号:
1006-1959（2021）12-0148-03
作者:
茹银转; 胡桂贞; 陈云开; 等
（东莞市石碣医院院感科1，妇产科2，眼科3，广东 东莞 523290）
Author(s):
RU Yin-zhuan; HU Gui-zhen; CHEN Yun-kai; et al.
(Department of Nosocomial Infection1,Department of Obstetrics and Gynecology2,Department of Ophthalmology3, Shijie Hospital,Dongguan 523290,Guangdong,China)
关键词:
尿路感染; 细菌分布; 基层医院; 革兰阴性菌; 革兰阳性菌
Keywords:
Urinary tract infection; Bacterial distribution; Primary hospitals; Gram-negative bacteria; Gram-positive bacteria
分类号:
R691.3
DOI:
10.3969/j.issn.1006-1959.2021.12.040
文献标志码:
A
摘要:
目的 监测和研究某基层医院2018年~2020年尿路感染的细菌分布及耐药状况。方法 选取2018年1月~2020年12月东莞市某基层医院609例尿路感染病例尿标本进行培养，采用KB纸片法进行药敏测定，分析致病菌分布及耐药情况。结果 609例尿路感染病例中，共检出菌株803株，其中革兰阴性菌71.48%，革兰阳性菌28.52%，革兰阴性菌前三位为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌，革兰阳性菌前三位为粪肠球菌、屎肠球菌和金黄色葡萄球菌；大肠埃希菌和肺炎克雷伯菌对氨苄西林、头孢唑啉、头孢呋辛、头孢噻肟、左氧氟沙星、复方新诺明唑耐药性较高，耐药率＞50%，且呈现逐年上升趋势，对头孢哌酮/舒巴坦、阿米卡星、呋喃妥因、厄他培南、亚胺培南、美罗培南敏感性较高，耐药率＜10%，且呈现逐年下降趋势；铜绿假单胞菌除对左氧氟沙星和哌拉西林的耐药率＞30%外，对其他抗菌药物的耐药率均＜20%，对亚胺培南和美罗培南耐药率均＜10%；粪肠球和屎肠球菌对红霉素、四环素、克林霉素耐药率高，均＞50%，且呈现逐年上升趋势；对氨苄西林、呋喃妥因、利奈唑胺、万古霉素、替考拉宁较敏感，耐药率＜30%，且呈现逐年下降趋势。结论 东莞市某基层医院尿路感染的病原菌以革兰阴性菌的大肠埃希菌、肺炎克雷伯菌和革兰阳性菌的粪肠球菌、屎肠球菌为主，它们对常用的治疗尿路感染药物耐药性逐年上升，细菌耐药形势严峻，对我院尿路感染患者治疗时应做药敏试验，合理选用抗菌药物。
Abstract:
Objective To monitor and study the bacterial distribution and drug resistance of urinary tract infections in a basic hospital from 2018 to 2020.Methods From January 2018 to December 2020, 609 urine specimens of urinary tract infection cases in a primary hospital in Dongguan City were selected for culture, and the KB paper method was used for drug susceptibility determination, and the distribution of pathogenic bacteria and drug resistance were analyzed.Results Among 609 cases of urinary tract infection, a total of 803 strains were detected, of which 71.48% were gram-negative bacteria, 28.52% were gram-positive bacteria, and the top three gram-negative bacteria were Escherichia coli, Klebsiella pneumoniae, and Klebsiella pneumoniae.Pseudomonas aeruginosa, the top three gram-positive bacteria were Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus;Escherichia coli and Klebsiella pneumoniae were highly resistant to ampicillin, cefazolin, cefuroxime, cefotaxime, levofloxacin, and compound trimethoprim, with a resistance rate of ＞50% and showing an upward trend year by year, the sensitivity to cefoperazone/sulbactam, amikacin, nitrofurantoin, ertapenem, imipenem, and meropenem was relatively high, and the drug resistance rate was less than 10% and showing a downward trend year by year; except for Pseudomonas aeruginosa, the resistance rate to levofloxacin and piperacillin was more than 30%, and the resistance rate to other antibacterial drugs was less than 20%.The resistance rate to imipenem and meropenem was less than 10%;Enterococcus faecalis and Enterococcus faecium had high resistance rates to erythromycin, tetracycline, and clindamycin, both ＞50%, and present an upward trend year by year;It was more sensitive to ampicillin, nitrofurantoin, linezolid, vancomycin, and teicoplanin, and the resistance rate was less than 30%, and it showed a downward trend year by year.Conclusion The pathogens of urinary tract infection in a primary hospital in Dongguan are mainly Gram-negative bacteria Escherichia coli, Klebsiella pneumoniae and Gram-positive bacteria Enterococcus faecalis and Enterococcus faecium. The resistance of infectious drugs is increasing year by year,The situation of bacterial resistance is severe, and susceptibility tests should be done when treating patients with urinary tract infection in our hospital, and antibiotics should be selected reasonably.

参考文献/References:

[1]孙丽,徐海红,王晖.尿培养细菌菌群分布及耐药性分析[J].安徽卫生职业技术学院学报,2016,15(2):137-138. [2]孙庆霞.104例非发热性下尿路感染患者中段尿细菌培养及主要致病菌分析[J].中国实验诊断学,2020,24(1):70-81. [3]郭瑞宾.泌尿外科危重症患者尿路感染病原学及其药敏分析[J].北方医学,2018,15(4):173-175. [4]陆再英,钟南山.内科学[M].第７版.北京:人民卫生出版社,2008:530-531. [5]叶应妩,王毓三,申子瑜.全国临床检验操作规程[M].第3版.南京:东南大学出版社,2006:743-744. [6]Clinical and Laboratory Standards Institute.M100-S26 Performance standards for antimicrobial susceptibility testing;Twenty-Forth informational supplement[J].Wayne,PA,CLSI,2016. [7]Clinical and Laboratory Standards Institute.M100-S23 Performance standards for antimicrobial susceptibility testing;Twenty-Forth informational supplement[J].Wayne,PA,CLSI,2013. [8]林佳.泌尿外科留置尿管患者预防尿路感染的临床护理观察[J].中国健康营养,2020,30(6):303. [9]王晓英,葛瑛,马小军.尿常规及尿培养与尿路感染诊断相关性探讨[J].中华内科杂志,2020,59(7):570-573. [10]管春霞.集束化护理对ICU留置尿管相关性尿路感染的预防作用分析[J].中国继续医学教育,2018,10(1):144-145. [11]张伟,金炎,黄敏,等.2014-2016年尿路感染的病原菌及耐药分析[J].新医学,2018,49(6):416-420. [12]杨银梅,叶惠芬,陈惠玲.广州地区尿路感染的病原菌分布及其耐药性[J].中国抗感染化疗杂志,2002,2(2):100-103. [13]王云娟,宋贵波,苏艳丹,等.2013-2015年云南省三级医院尿培养病原菌分布及耐药性分析[J].中国抗生素杂志,2017,42(7):548-560. [14]孙庆霞.104例非发热性下尿路感染患者中段尿细菌培养及主要致病菌分析[J].中国实验诊断学,2020,24(1):79-81.

相似文献/References:

[1]柳 梅.头孢哌酮钠舒巴坦钠治疗糖尿病并发尿路感染的 临床效果观察[J].医学信息,2018,31(07):139.[doi:10.3969/j.issn.1006-1959.2018.07.047]
　LIU Mei.Clinical Efficacy of Cefoperazone Sodium and Sulbactam Sodium in Treatment of Diabetes Complicated with Urinary Tract Infection[J].Medical Information,2018,31(12):139.[doi:10.3969/j.issn.1006-1959.2018.07.047]
[2]钱菲菲,周 易.尿路感染诊断治疗中临床微生物检验的病原菌结果分析[J].医学信息,2022,35(23):159.[doi:10.3969/j.issn.1006-1959.2022.23.035]
　QIAN Fei-fei,ZHOU Yi.Analysis of Pathogenic Bacteria Results of Clinical Microbiological Examination in the Diagnosis and Treatment of Urinary Tract Infection[J].Medical Information,2022,35(12):159.[doi:10.3969/j.issn.1006-1959.2022.23.035]
[3]雷 欣,陈筱云.糖尿病合并尿路感染中医临证治验[J].医学信息,2021,34(07):162.[doi:10.3969/j.issn.1006-1959.2021.07.046]
[4]魏长斌.头孢哌酮钠舒巴坦钠对糖尿病合并尿路感染的疗效及安全性分析[J].医学信息,2021,34(14):151.[doi:10.3969/j.issn.1006-1959.2021.14.042]
　WEI Chang-bin.Analysis of the Efficacy and Safety of Cefoperazone Sodium and Sulbactam Sodium on Diabetes Complicated with Urinary Tract Infection[J].Medical Information,2021,34(12):151.[doi:10.3969/j.issn.1006-1959.2021.14.042]
[5]肖春芳.尿路感染患者奇异变形杆菌分布及耐药性分析[J].医学信息,2021,34(24):187.[doi:10.3969/j.issn.1006-1959.2021.24.051]
　XIAO Chun-fang.Distribution and Drug Resistance of Proteus Mirabilis in Patients with Urinary Tract Infection[J].Medical Information,2021,34(12):187.[doi:10.3969/j.issn.1006-1959.2021.24.051]
[6]邹 莉,邹长娇,陈丽华.新型泌尿外科护理管理模式对外科住院患者治疗及降低院内尿路感染的影响[J].医学信息,2024,37(05):161.[doi:10.3969/j.issn.1006-1959.2024.05.030]
　ZOU Li,ZOU Chang-jiao,CHEN Li-hua.Effect of New Urological Nursing Management Model on the Treatment and the Reduction of Nosocomial Urinary Tract Infection for Surgical Inpatients[J].Medical Information,2024,37(12):161.[doi:10.3969/j.issn.1006-1959.2024.05.030]

更新日期/Last Update: 1900-01-01