[1]严名扬,唐臻一.急性骨骼肌损伤实验动物模型种类和选择[J].医学信息,2021,34(13):48-52.[doi:10.3969/j.issn.1006-1959.2021.13.013]
 YAN Ming-yang,TANG Zhen-yi.Types and Selection of Experimental Animal Models of Acute Skeletal Muscle Injury[J].Medical Information,2021,34(13):48-52.[doi:10.3969/j.issn.1006-1959.2021.13.013]
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急性骨骼肌损伤实验动物模型种类和选择()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年13期
页码:
48-52
栏目:
综述
出版日期:
2021-07-01

文章信息/Info

Title:
Types and Selection of Experimental Animal Models of Acute Skeletal Muscle Injury
文章编号:
1006-1959(2021)13-0048-05
作者:
严名扬唐臻一
(天津市北辰区中医医院急诊科1,骨伤科2,天津 300400)
Author(s):
YAN Ming-yangTANG Zhen-yi
(Emergency Department1,Department of Orthopedics and Traumatology2,Tianjin Beichen Traditional Chinese Medicine Hospital, Tianjin 300400,China)
关键词:
急性骨骼肌损伤修复动物模型
Keywords:
Acute skeletal muscle injuryRepairAnimal model
分类号:
G804.53;R873;R274.3
DOI:
10.3969/j.issn.1006-1959.2021.13.013
文献标志码:
A
摘要:
急性骨骼肌损伤后纤维化、慢性炎症等不完全性修复,常导致肢体疼痛、功能恢复不全等后遗症,成为临床上面临的主要难题和挑战。对骨骼肌损伤发病机制的实验研究需要建立在良好的损伤模型基础上,各种动物模型的建立适用于不同的研究目的。梳理开放性肌肉牵拉伤、闭合性电刺激牵拉伤、力竭性损伤、撞击伤、割裂伤、缺血再灌注损伤等模型,探讨各实验动物模型在损伤造模机制、肌群、实验动物种属等方面的选择;合理地选择大鼠非侵入性的骨骼肌损伤模型具有一定的合理性,而根据具体临床疾患模拟的实验目的和客观条件,各类动物模型均具有自身优势和现实意义。
Abstract:
Incomplete repair of fibrosis and chronic inflammation after acute skeletal muscle injury often leads to sequelae such as limb pain and incomplete functional recovery, which has become the main clinical problem and challenge.Experimental research on the pathogenesis of skeletal muscle injury needs to be established on the basis of a good injury model. The establishment of various animal models is suitable for different research purposes.Sort out models of open muscle traction, closed electrical stimulation, exhaustion, impact, laceration, ischemia-reperfusion injury, etc.Explore the selection of experimental animal models in terms of injury modeling mechanism, muscle groups, and experimental animal species;It is reasonable to choose a non-invasive skeletal muscle injury model in rats reasonably.According to the experimental purpose and objective conditions of specific clinical disease simulation, various animal models have their own advantages and practical significance.

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更新日期/Last Update: 1900-01-01