[1]范叶柏,宫 雪,杨晓晨.米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的临床安全性和有效性比较[J].医学信息,2021,34(13):170-172.[doi:10.3969/j.issn.1006-1959.2021.13.047]
　FAN Ye-bai,GONG Xue,YANG Xiao-chen.Comparison of the Clinical Safety and Effectiveness of Mifepristone Combined with Methotrexate and Methotrexate Alone in the Treatment of Ectopic Pregnancy[J].Medical Information,2021,34(13):170-172.[doi:10.3969/j.issn.1006-1959.2021.13.047]
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米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的临床安全性和有效性比较()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年13期
页码:
170-172
栏目:
药物与临床
出版日期:
2021-07-01

文章信息/Info

Title:
Comparison of the Clinical Safety and Effectiveness of Mifepristone Combined with Methotrexate and Methotrexate Alone in the Treatment of Ectopic Pregnancy
文章编号:
1006-1959（2021）13-0170-03
作者:
范叶柏; 宫 雪; 杨晓晨
（佳木斯市妇幼保健院生殖医学科，黑龙江 佳木斯 154002）
Author(s):
FAN Ye-bai; GONG Xue; YANG Xiao-chen
(Department of Reproductive Medicine,Jiamusi Maternal and Child Health Hospital/Jiamusi Anorectal Hospital, Jiamusi 154002,Heilongjiang,China)
关键词:
米非司酮; 甲氨蝶呤; 宫外孕
Keywords:
Mifepristone; Methotrexate; Ectopic pregnancy
分类号:
R714.22
DOI:
10.3969/j.issn.1006-1959.2021.13.047
文献标志码:
A
摘要:
目的 研究米非司酮联合甲氨蝶呤治疗宫外孕的临床有效性和安全性。方法 选取2019年10月~2020年10月我院诊治的74例宫外孕患者为研究对象，采用随机数字表法分为对照组和观察组，各37例。对照组采用单纯甲氨蝶呤治疗，观察组在对照组基础上联合米非司酮治疗，比较两组临床治疗总有效率、临床症状改善时间、血清孕酮和β-HCG水平以及临床不良反应发生情况。结果 观察组治疗总有效率为97.29%，高于对照组的81.08%，差异有统计学意义（P＜0.05）；观察组包块消失、腹痛消失、阴道止血、血β－HCG转阴、孕酮恢复正常以及月经复潮时间均短于对照组，差异有统计学意义（P＜0.05）；观察组血清孕酮、β-HCG水平低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为8.11%，与对照组的10.81%比较，差异无统计学意义（P＞0.05）。结论 米非司酮联合甲氨蝶呤治疗宫外孕效果优于单纯甲氨蝶呤，可提高患者治疗总有效率，缩短临床症状改善时间，降低血清孕酮和β-HCG水平，且临床不良反应少，具有应用有效性和安全性。
Abstract:
Objective To study the clinical effectiveness and safety of mifepristone combined with methotrexate in the treatment of ectopic pregnancy.Methods A total of 74 patients with ectopic pregnancy diagnosed and treated in our hospital from October 2019 to October 2020 were selected as the research objects. They were divided into the control group and the observation group by random number table method, with 37 cases in each group.The control group was treated with methotrexate alone, and the observation group was treated with mifepristone on the basis of the control group.The total effective rate of clinical treatment, clinical symptom improvement time, serum progesterone and β-HCG levels, and the occurrence of clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.29%, which was higher than 81.08% in the control group,the difference was statistically significant(P<0.05);The observation group’s mass disappearance, abdominal pain disappeared, vaginal hemostasis, blood β-HCG became negative, progesterone returned to normal, and menstrual re-moisture time were shorter than those of the control group, the difference was statistically significant (P<0.05);The levels of serum progesterone and β-HCG in the observation group were lower than those in the control group,the difference was statistically significant (P＜0.05);The incidence of adverse reactions in the observation group was 8.11%, compared with 10.81% in the control group, the difference was not statistically significant (P>0.05).Conclusion The effect of mifepristone combined with methotrexate in the treatment of ectopic pregnancy is better than that of methotrexate alone, which can increase the total effective rate of treatment and shorten the time for improvement of clinical symptoms.It reduces serum progesterone and β-HCG levels, and has fewer clinical adverse reactions, and has application effectiveness and safety.

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更新日期/Last Update: 1900-01-01