[1]许子贤,王 丹.BNP/NT-proBNP及心肌酶谱联合检测诊断新生儿肺炎的价值[J].医学信息,2021,34(17):107-110.[doi:10.3969/j.issn.1006-1959.2021.17.027]
 XU Zi-xian,WANG Dan.The Value of Combined Detection of BNP/NT-proBNP and Myocardial Enzyme Spectrum in the Diagnosis of Neonatal Pneumonia[J].Medical Information,2021,34(17):107-110.[doi:10.3969/j.issn.1006-1959.2021.17.027]
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BNP/NT-proBNP及心肌酶谱联合检测诊断新生儿肺炎的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年17期
页码:
107-110
栏目:
论著
出版日期:
2021-09-01

文章信息/Info

Title:
The Value of Combined Detection of BNP/NT-proBNP and Myocardial Enzyme Spectrum in the Diagnosis of Neonatal Pneumonia
文章编号:
1006-1959(2021)17-0107-04
作者:
许子贤王 丹
(1.天津市胸科医院检验科,天津 300222; 2.延安市中医医院检验科,陕西 延安 716000)
Author(s):
XU Zi-xianWANG Dan
(1.Department of Laboratory Medicine,Tianjin Chest Hospital,Tianjin 300222,China; 2.Department of Laboratory Medicine,Yan’an City Hospital of TCM,Yan’an 716000,Shaanxi,China)
关键词:
脑利钠肽N末端B型利钠肽原心肌酶谱新生儿肺炎
Keywords:
Brain natriuretic peptideN-terminal pro-B-type natriuretic peptideMyocardial zymogramNeonatal pneumonia
分类号:
R722.13+5
DOI:
10.3969/j.issn.1006-1959.2021.17.027
文献标志码:
A
摘要:
目的 探究脑利钠肽(BNP)/N末端B型利钠肽原(NT-proBNP)及心肌酶谱联合检测在新生儿肺炎(NP)诊断中的价值。方法 选取2019年6月-2020年6月出生于我院的141例NP患儿,根据感染类型分为细菌组60例、病毒组51例和其他组30例,另选取同期出生于我院的30例健康新生儿作为对照组。比较各组BNP/NT-proBNP、心肌酶谱水平;采用受试者工作特征(ROC)曲线分析BNP/NT-proBNP及心肌酶谱联合检测对NP的诊断价值。结果 三组NP患儿BNP/NT-proBNP低于对照组,其中细菌组BNP/NT-proBNP低于病毒组、其他组,病毒组低于其他组,差异均有统计学意义(P<0.05);三组NP患儿心肌酶谱水平高于对照组,且病毒组高于细菌组、其他组,细菌组高于其他组,差异有统计学意义(P<0.05);BNP/NT-proBNP对NP细菌感染的诊断效能较高,心肌酶谱对NP病毒感染的诊断效能较高,BNP/NT-proBNP及心肌酶谱联合检测诊断NP的灵敏度、特异性、准确度、阳性预测值、阴性预测值、ROC曲线下面积(AUC)均高于单一指标检测的值,差异有统计学意义(P<0.05)。结论 BNP/NT-proBNP及心肌酶谱联合检测能够有效诊断NP及指导临床合理使用抗菌药物,值得推广应用。
Abstract:
Objective To explore the value of combined detection of brain natriuretic peptide (BNP)/N-terminal pro-B-type natriuretic peptide (NT-proBNP) and myocardial zymogram in the diagnosis of neonatal pneumonia (NP).Methods A total of 141 children with NP who were born in our hospital between June 2019 and June 2020 were selected. According to the type of infection, they were divided into 60 cases in the bacterial group, 51 cases in the virus group, and 30 cases in the other groups.In addition, 30 healthy newborns who were born in our hospital during the same period were selected as the control group.The levels of BNP/NT-proBNP and myocardial zymogram were compared in each group; receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of combined detection of BNP/NT-proBNP and myocardial zymogram for NP.Results The BNP/NT-proBNP of the three groups of children with NP was lower than that of the control group. The BNP/NT-proBNP of the bacterial group was lower than that of the virus group, other groups, and the virus group was lower than other groups,the differences were statistically significant (P<0.05) ;The levels of myocardial enzymes in the three groups of NP children were higher than those of the control group, and the virus group was higher than the bacteria group and other groups, and the bacterial group was higher than the other groups,the difference was statistically significant(P<0.05);BNP/NT-proBNP has higher diagnostic efficiency for NP bacterial infection, and myocardial enzyme spectrum has higher diagnostic efficiency for NP virus infection.The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and area under the ROC curve (AUC) of the combined detection of BNP/NT-proBNP and myocardial enzyme spectrum in the diagnosis of NP were all higher than the value detected by a single index,the difference was statistically significant (P<0.05).Conclusion The combined detection of BNP/NT-proBNP and myocardial enzyme spectrum can effectively diagnose NP and guide the clinical rational use of antibacterial drugs, and it is worthy of popularization and application.

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更新日期/Last Update: 1900-01-01