[1]彭 馨,杨 鹏,刘正奇,等.原发性干燥综合征Th17/Treg平衡调节研究[J].医学信息,2021,34(18):28-31.[doi:10.3969/j.issn.1006-1959.2021.18.007]
 PENG Xin,YANG Peng,LIU Zheng-qi,et al.Study on Th17/Treg Balance Regulation in Primary Sjogren’s Syndrome[J].Medical Information,2021,34(18):28-31.[doi:10.3969/j.issn.1006-1959.2021.18.007]
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原发性干燥综合征Th17/Treg平衡调节研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年18期
页码:
28-31
栏目:
综述
出版日期:
2021-09-18

文章信息/Info

Title:
Study on Th17/Treg Balance Regulation in Primary Sjogren’s Syndrome
文章编号:
1006-1959(2021)18-0028-04
作者:
彭 馨1杨 鹏2刘正奇2杨道斌2朱胜金2
1.贵州中医药大学研究生院,贵州 贵阳 550002;2.贵州中医药大学第二附属医院风湿免疫科,贵州 贵阳 550003
Author(s):
PENG Xin1YANG Peng2LIU Zheng-qi2YANG Dao-bin2ZHU Sheng-jin2
1.Graduate School,Guizhou University of Traditional Chinese Medicine,Guiyang 550002,Guizhou,China;2.Department of Rheumatology and Immunology,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,Guizhou,China
关键词:
原发性干燥综合征Th17细胞Treg细胞细胞因子
Keywords:
Primary Sjogren’s syndromeTh17 cellsTreg cellsCytokines
分类号:
R593
DOI:
10.3969/j.issn.1006-1959.2021.18.007
文献标志码:
A
摘要:
原发性干燥综合征(pSS)是一种以淋巴细胞浸润外分泌腺及腺外组织为主要特征的自身免疫性疾病。该病浸润的淋巴细胞多数为CD4+T细胞。Th17是近年来新发现的Th细胞谱系,目前多认为Th17/Treg平衡偏向Th17炎症轴是导致干燥综合征发生发展的重要原因。本文主要对Th17/Treg平衡调节的理论基础以及原发性干燥综合征的候选疗法进行综述,帮助临床明确Th17、Th17/Treg平衡在原发性干燥综合征中的作用。
Abstract:
Primary Sjogren’s syndrome (pSS) is an autoimmune disease characterized by lymphocytes infiltrating exocrine glands and extraglandular tissues.Most of the lymphocytes infiltrated by this disease are CD4+ T cells. Th17 is a newly discovered Th cell lineage in recent years,at present, it is generally believed that Th17/Treg balance is biased towards the Th17 inflammation axis as an important reason for the development of Sjogren’s syndrome.This article mainly reviews the theoretical basis of Th17/Treg balance regulation and candidate treatments for primary Sjogren’s syndrome, to help clinically clarify the role of Th17 and Th17/Treg balance in primary Sjogren’s syndrome.

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更新日期/Last Update: 1900-01-01