[1]白 雪,刘玉嵚,苏桂芳.达那唑联合醋酸亮丙瑞林微球治疗子宫内膜异位症的疗效及自然妊娠情况[J].医学信息,2021,34(18):152-154.[doi:10.3969/j.issn.1006-1959.2021.18.041]
　BAI Xue,LIU Yu-qin,SU Gui-fang.Efficacy of Danazol Combined with Leuprorelin Acetate Microspheres in theTreatment of Endometriosis and Natural Pregnancy[J].Medical Information,2021,34(18):152-154.[doi:10.3969/j.issn.1006-1959.2021.18.041]
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达那唑联合醋酸亮丙瑞林微球治疗子宫内膜异位症的疗效及自然妊娠情况()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年18期
页码:
152-154
栏目:
药物与临床
出版日期:
2021-09-18

文章信息/Info

Title:
Efficacy of Danazol Combined with Leuprorelin Acetate Microspheres in theTreatment of Endometriosis and Natural Pregnancy
文章编号:
1006-1959（2021）18-0152-03
作者:
白 雪; 刘玉嵚; 苏桂芳
青海省红十字医院妇四科，青海 西宁 810000
Author(s):
BAI Xue; LIU Yu-qin; SU Gui-fang
The Fourth Department of Gynecology,Qinghai Red Cross Hospital,Xining 810000,Qinghai,China
关键词:
达那唑; 醋酸亮丙瑞林微球; 子宫内膜异位症; 性激素; 基质金属蛋白酶-9; 血管内皮生长因子
Keywords:
Danazol; Leuprorelin Acetate Microspheres; Endometriosis; Sex hormones; Matrix metalloproteinase-9; Vascular endothelial growth factor
分类号:
R711.71
DOI:
10.3969/j.issn.1006-1959.2021.18.041
文献标志码:
A
摘要:
目的 探讨术后应用达那唑联合醋酸亮丙瑞林微球治疗子宫内膜异位症（EMs）的疗效及自然妊娠情况。方法 收集我院2017年1月-2019年8月110例行手术治疗的EMs患者作为观察对象，随机分为对照组和观察组，每组55例。对照组术后给予达那唑治疗，观察组给予达那唑联合醋酸亮丙瑞林微球治疗。比较两组临床疗效、治疗前后性激素水平、基质金属蛋白酶-9（MMP-9）、血管内皮生长因子（VEGF）水平及自然妊娠率。结果 观察组总有效率为94.55%，高于对照组的81.82%，差异有统计学意义（P＜0.05）；观察组黄体生成素（LH）、孕激素（P）、卵泡雌激素（FSH）、雌二醇（E2）水平、MMP-9及VEGF水平均低于对照组，差异有统计学意义（P＜0.05）；随访2年，观察组自然妊娠率为83.64%，高于对照组的67.27%，差异有统计学意义（P＜0.05）。结论 术后应用达那唑联合醋酸亮丙瑞林微球治疗EMs疗效确切，在改善患者临床症状同时，能够降低性激素及MMP-9、VEGF水平，能够提高自然妊娠率。
Abstract:
Objective To investigate the postoperative application of danazol combined with Leuprorelin Acetate Microspheres in the treatment of endometriosis (EMs) and the natural pregnancy.Methods A total of 110 patients with EMs who underwent surgical treatment in our hospital from January 2017 to August 2019 were collected as observation objects, and they were randomly divided into control group and observation group, with 55 cases in each group. The control group was treated with danazol after operation, and the observation group was treated with danazol combined with Leuprorelin Acetate Microspheres.The clinical efficacy, sex hormone levels before and after treatment, matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF) levels and natural pregnancy rate were compared between the two groups.Results The total effective rate of the observation group was 94.55% higher than 81.82% in the control group,the difference was statistically significant (P＜0.05);The levels of luteinizing hormone (LH), progesterone (P), follicular estrogen (FSH), estradiol (E2) and the levels of MMP-9 and VEGF in the observation group were lower than those in the control group,the difference was statistically significant (P＜0.05).After 2 years of follow-up, the natural pregnancy rate of the observation group was 83.64% higher than 67.27% in the control group,the difference was statistically significant (P＜0.05).Conclusion The postoperative application of danazol combined with Leuprorelin Acetate Microspheres in the treatment of EMs has a definite effect. It can improve the clinical symptoms of patients, while reducing the levels of sex hormones, MMP-9 and VEGF, and can increase the natural pregnancy rate.

参考文献/References:

[1]Yi D,Li X,Shi J,et al.A review of the risk factors,genetics and treatment of endometriosis in Chinese women:a comparative update[J].Reproductive Health,2018,15(1):82.[2]李荣.子宫内膜异位症合并不孕症患者腹腔镜术后妊娠的影响因素分析[J].中国医师杂志,2020,22(4):595-598.[3]张春霞,蔡俊,李艳丽,等.腹腔镜术后孕三烯酮与诺雷德治疗卵巢型子宫内膜异位症的疗效对比及复发相关因素分析[J].安徽医学,2020,41(2):181-186.[4]张保华,蔡丽虹,王亚婷,等.丹莪妇康煎膏联合GnRH-a预防子宫内膜异位症患者术后复发的疗效分析[J].医药论坛杂志,2020,41(7):53-56.[5]邱晓红,韩丽英,李荷莲.血清基质金属蛋白酶-9诊断子宫内膜异位症术后复发的价值[J].中国免疫学杂志,2006,22(3):272-273.[6]郁平,姬小凡,王敏,等.腹腔镜手术联合亮丙瑞林、戊酸雌二醇治疗子宫内膜异位症效果及对腹腔液血管内皮生长因子、糖类抗原125水平影响[J].临床误诊误治,2020,33(2):46-51.[7]中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症的诊治指南[J].中华妇产科杂志,2015,50(3):161-169.[8]王利娟,赵麦娟.腹腔镜手术分别联合GnRH-a与孕三烯酮治疗子宫内膜异位症的临床效果分析[J].贵州医药,2020,44(4):592-593.[9]侯丽娟,翟建军,曹京红,等.腹腔镜手术联合GnRH-a治疗子宫内膜异位症临床效果及对患者卵巢功能的影响[J].山东医药,2019,59(14):75-77.[10]Berlanda N,Somigliana E,Viganò P,et al.Safety of medical treatments for endometriosis[J].Expert Opin Drug Saf,2016,15(1):21-30.[11]刘阳,许汴菊.醋酸亮丙瑞林微球在子宫腺肌病合并不孕患者行体外受精-胚胎移植治疗中的应用[J].陕西医学杂志,2020,49(2):223-226.[12]杨莉.LNG-IUS联用注射用醋酸亮丙瑞林微球治疗子宫腺肌症的疗效[J].中国合理用药探索,2019,16(10):35-38.[13]顾晓荔,吴新华,姬梦鸽,等.子宫内膜异位症患者血清TIMP-1、MCP-1、MMP-9水平及与不孕的关系[J].分子诊断与治疗杂志,2020,12(2):234-238.[14]高扬,朱艳.子宫内膜异位症合并不孕患者血清中基质金属蛋白酶-9、基质金属蛋白酶抑制剂-1、血管内皮生长因子可溶性受体、胰岛素生长因子-1、单核细胞趋化蛋白-1表达水平及临床意义[J].陕西医学杂志,2020,49(4):462-465,501.[15]郑春娇,郑春玉,陈小娟,等.血清血管内皮生长因子、泌乳素和人附睾蛋白4联合检测对子宫内膜异位症的诊断价值[J].中国临床医生杂志,2020,48(1):110-112.[16]南燕,侯妍妍,李玉洁.不同剂量米非司酮对子宫内膜异位症大鼠异位内膜组织中环氧合酶-2和血管内皮生长因子表达的影响[J].新乡医学院学报,2019,36(6):521-524.

更新日期/Last Update: 1900-01-01