[1]凌大军,许映红.不同他汀类药物治疗老年冠心病的疗效比较[J].医学信息,2021,34(18):158-160.[doi:10.3969/j.issn.1006-1959.2021.18.043]
 LING Da-jun,XU Ying-hong.Comparison of the Efficacy of Different Statins in the Treatment ofCoronary Heart Disease in the Elderly[J].Medical Information,2021,34(18):158-160.[doi:10.3969/j.issn.1006-1959.2021.18.043]
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不同他汀类药物治疗老年冠心病的疗效比较()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年18期
页码:
158-160
栏目:
药物与临床
出版日期:
2021-09-18

文章信息/Info

Title:
Comparison of the Efficacy of Different Statins in the Treatment ofCoronary Heart Disease in the Elderly
文章编号:
1006-1959(2021)18-0158-03
作者:
凌大军许映红
如皋市中医院药剂科,江苏 如皋 226500
Author(s):
LING Da-junXU Ying-hong
Department of Pharmacy,Rugao Traditional Chinese Medicine Hospital,Rugao 226500,Jiangsu,China
关键词:
他汀类药物冠心病空腹血糖炎症因子
Keywords:
StatinsCoronary heart diseaseFasting blood glucoseInflammatory factors
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2021.18.043
文献标志码:
A
摘要:
目的 研究不同他汀类药物在老年冠心病患者中的应用疗效及安全性。方法 选取2019年6月-2020年6月我院治疗的72例老年冠心病患者为研究对象,采用随机数字表法分为对照组和观察组,各36例。对照组采用瑞舒伐他汀治疗,观察组采用阿托伐他汀治疗,比较两组临床治疗疗效、心脏功能指标(心率、左室射血分数、心脏指数)、空腹血糖、血脂指标[低密度脂蛋白胆固醇(LDL-C)、血清总胆固醇(TC)]及炎症因子[超敏C反应蛋白(hs-CRP)]以及临床不良反应发生情况。结果 观察组治疗总有效率为94.44%,与对照组的91.67%比较,差异无统计学意义(P>0.05);两组治疗后心率小于治疗前,左室射血分数、心脏指数均大于治疗前,差异有统计学意义(P<0.05),但组间比较,差异无统计学意义(P>0.05);两组治疗后空腹血糖、LDL-C、TC、hs-CRP均低于治疗前,差异有统计学意义(P<0.05),但组间比较,差异无统计学意义(P>0.05);观察组不良反应发生率为8.33%,与对照组的11.11%比较,差异无统计学意义(P>0.05)。结论 瑞舒伐他汀和阿托伐他汀治疗老年冠心病效果确切,均可有效改善患者心功能,降低空腹血糖、血脂指标以及炎症因子指标水平,且不良反应发生率低,应用安全有效。
Abstract:
Objective To study the efficacy and safety of different statins in elderly patients with coronary heart disease.Methods A total of 72 elderly patients with coronary heart disease treated in our hospital from June 2019 to June 2020 were selected as the research objects. They were divided into a control group and an observation group using a random number table method, with 36 cases in each group.The control group was treated with rosuvastatin, and the observation group was treated with atorvastatin.Compare the clinical treatment efficacy, cardiac function indexes (heart rate, left ventricular ejection fraction, heart index), fasting blood glucose, blood lipid indexes [low density lipoprotein cholesterol (LDL-C), serum total cholesterol (TC)] and inflammatory factors between the two groups [Hypersensitive C-reactive protein (hs-CRP)] and the occurrence of clinical adverse reactions.Results The total effective rate of treatment in the observation group was 94.44%, compared with 91.67% in the control group, the difference was not statistically significant (P>0.05);The heart rate after treatment in the two groups was lower than before treatment, and the left ventricular ejection fraction and cardiac index were higher than before treatment,the difference was statistically significant(P<0.05).However, the difference between the groups was not statistically significant (P>0.05);The fasting blood glucose, LDL-C, TC, and hs-CRP after treatment in the two groups were all lower than before treatment,the difference was statistically significant(P<0.05).However, the difference between the groups was not statistically significant (P>0.05);The incidence of adverse reactions in the observation group was 8.33%, compared with 11.11% in the control group, the difference was not statistically significant (P>0.05).Conclusion Rosuvastatin and atorvastatin are effective in the treatment of elderly coronary heart disease. They can effectively improve the heart function of patients, reduce the levels of fasting blood glucose, blood lipids and inflammatory factors, and have a low incidence of adverse reactions. The application is safe and effective.

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更新日期/Last Update: 1900-01-01