[1]李 波.IL-17A及IL-17F基因多态性与骨关节炎发病风险关系的Meta分析[J].医学信息,2021,34(20):85-89.[doi:10.3969/j.issn.1006-1959.2021.20.021]
 LI Bo.Meta-analysis of the Relationship Between IL-17A and IL-17F GenePolymorphisms and the Risk of Osteoarthritis[J].Medical Information,2021,34(20):85-89.[doi:10.3969/j.issn.1006-1959.2021.20.021]
点击复制

IL-17A及IL-17F基因多态性与骨关节炎发病风险关系的Meta分析()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年20期
页码:
85-89
栏目:
论著
出版日期:
2021-10-20

文章信息/Info

Title:
Meta-analysis of the Relationship Between IL-17A and IL-17F GenePolymorphisms and the Risk of Osteoarthritis
文章编号:
1006-1959(2021)20-0085-05
作者:
李 波
天津中医药大学附属武清区中医医院骨科,天津 301700
Author(s):
LI Bo
Department of Orthopedics,Wuqing District Hospital of Traditional Chinese Medicine,Tianjin University ofTraditional Chinese Medicine,Tianjin 301700,China
关键词:
骨关节炎白介素17基因多样性
Keywords:
OsteoarthritisInterleukin17Polymorphisms
分类号:
R392
DOI:
10.3969/j.issn.1006-1959.2021.20.021
文献标志码:
A
摘要:
目的 研究白介素(IL)-17A(rs2275913)及IL-17F(rs763780)基因多态性和与骨关节炎(OA)发病风险及易感性。方法 检索PubMed、EMbase、Web of Science、中国学术期刊全文数据库(CNKI)、万方数据库已发表的与IL-17、基因多态性及骨关节炎相关的文献进行Meta分析,截止至2020年3月。结果 纳入7篇文章(共计9项研究),共收集OA患者2311例,其中检测rs2275913基因2187例,rs763780基因 2272例;对照组3096例,其中检测rs2275913基因2715例,rs763780基因 2956例。Meta分析结果显示:总体人种IL-17F基因各SNP遗传模型(等位基因模型、共显性模型、显性模型及隐性模型)与OA易感性相关(P<0.05);亚组分析结果显示:黄种人中与IL-17F基因各基因模型与OA易感性仍然密切相关,白种人中只有等位基因模型、显性模型与之相关(P<0.05);总体人种IL-17A各SNP基因模型与OA易感性均无相关性(P>0.05),亚组分析中IL-17A基因与OA仍无相关性(P>0.05)。结论 IL-17F(rs763780)在基因多态性方面是OA的危险因素,且黄种人较白种人更为易感,IL-17A(rs2275913)与OA的易感关系仍然需要更多样本进一步证实。
Abstract:
Objective To investigate the association between interleukin (IL)-17A (rs2275913) and IL-17F (rs763780) gene polymorphism and the risk and susceptibility of osteoarthritis (OA).Methods The literatures related to IL-17, gene polymorphism and osteoarthritis published in PubMed, Embase, Web of Science, CNKI and Wanfang database were retrieved for Meta-analysis. The literatures were collected by the end of March 2020.Results Seven articles (a total of 9 studies) were included. A total of 2311 patients with OA were collected, including 2187 cases of rs2275913 gene and 2272 cases of rs763780 gene. There were 3096 cases in the control group, including 2715 cases of rs2275913 gene and 2956 cases of rs763780 gene. The results of meta-analysis showed that the SNP genetic models (allele model, codominant model, dominant model and recessive model) of IL-17F gene in the overall population were associated with OA susceptibility (P<0.05). The subgroup analysis results showed that the genetic models of IL-17F gene and OA susceptibility in yellow population were still closely related, and only allele model and dominant model in white population were related (P<0.05);there was no correlation between IL-17A SNP gene models and OA susceptibility in the general population (P>0.05); there was no correlation between IL-17 A gene and OA in subgroup analysis (P>0.05).Conclusion IL-17F (rs763780) is a risk factor for OA in terms of gene polymorphism, and the yellow population is more susceptible to OA than the white population. The relationship between IL-17A (rs2275913) and OA susceptibility still needs more samples to be further confirmed.

参考文献/References:

[1]Liu-Bryan R.Inflammation and intracellular metabolism: new targets in OA[J].Osteoarthritis Cartilage,2015,23(11):1835-1842.[2]Rychel JK.Diagnosis and treatment of osteoarthritis[J].Top Companion Anim Med,2010,25(1):20-25.[3]Martel-Pelletier J,Maheu E,Pelletier JP,et al.A new decision tree for diagnosis of osteoarthritis in primary care: international consensus of experts[J].Aging Clin Exp Res,2019,31(1):19-30.[4]Nees TA,Rosshirt N,Reiner T,et al.Inflammation and osteoarthritis-related pain[J].Schmerz,2019,33(1):4-12.[5]Beringer A,Noack M,Miossec P.IL-17 in Chronic Inflammation: From Discovery to Targeting[J].Trends Mol Med,2016,22(3):230-241.[6]Hot A,Miossec P.Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes[J].Ann Rheum Dis,2011,70(5):727-732.[7]Gracey E,Qaiyum Z,Almaghlouth I,et al.IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis[J].Ann Rheum Dis,2016,75(12):2124-2132.[8]Deligne C,Casulli S,Pigenet A,et al.Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients[J].Osteoarthritis Cartilage,2015,23(11):1843-1852.[9]Bafrani HH,Ahmadi M,Jahantigh D,et al.Association analysis of the common varieties of IL17A and IL17F genes with the risk of knee osteoarthritis[J].J Cell Biochem,2019,120(10):18020-18030.[10]Vrgoc G,Vrbanec J,Eftedal RK,et al.Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis[J].J Orthop Res,2018,36(6):1684-1693.[11]Jiang L,Zhou X,Xiong Y,et al.Association between interleukin-17A/F single nucleotide polymorphisms and susceptibility to osteoarthritis in a Chinese population[J].Medicine (Baltimore),2019,98(12):e14944.[12]Han L,Lee HS,Yoon JH,et al.Association of IL-17A and IL-17F single nucleotide polymorphisms with susceptibility to osteoarthritis in a Korean population[J].Gene,2014,533(1):119-122.[13]张海森,白玉明,靳胜利,等.白细胞介素-17基因多态性与骨关节炎易感性之间的相关性研究[J].中华骨科杂志,2016,36(22):1450-1455.[14]张培莉,杨发满,乔志忠,等.白细胞介素17A和17F单核苷酸多态性与膝骨关节炎的相关性[J].中华医学杂志,2019,99(24):1870-1874.[15]Bai Y,Gao S,Liu Y,et al.Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population[J].BMC Med Genet,2019,20(1):20.[16]McGeachy MJ,Cua DJ,Gaffen SL.The IL-17 Family of Cytokines in Health and Disease[J].Immunity,2019,50(4):892-906.[17]Robak E,Gerlicz-Kowalczuk Z,Dziankowska-Bartkowiak B,et al.Serum concentrations of IL-17A, IL-17B, IL-17E and IL-17F in patients with systemic sclerosis[J].Arch Med Sci,2019,15(3):706-712.[18]Bie Q,Jin C,Zhang B,et al.IL-17B: A new area of study in the IL-17 family[J].Mol Immunol,2017(90):50-56.[19]Jungnickel C,Schmidt LH,Bittigkoffer L,et al.IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth[J].Oncogene,2017,36(29):4182-4190.[20]Huang J,Meng S,Hong S,et al.IL-17C is required for lethal inflammation during systemic fungal infection[J].Cell Mol Immunol,2016,13(4):474-483.[21]O’Sullivan T,Saddawi-Konefka R,Gross E,et al.Interleukin-17D mediates tumor rejection through recruitment of natural killer cells[J].Cell Rep,2014,7(4):989-998.[22]Senra L,Mylonas A,Kavanagh RD,et al.IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation[J].J Invest Dermatol,2019,139(8):1732-1742,e17.[23]Liu Y,Peng H,Meng Z,et al.Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis[J].Med Sci Monit,2015(21):1732-1736.[24]Zhu Z,Otahal P,Wang B,et al.Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis[J].Osteoarthritis Cartilage,2017,25(4):499-505.[25]Yu ZG,Wang BZ,Li J,et al.Association between interleukin-17 genetic polymorphisms and tuberculosis susceptibility: an updated meta-analysis[J].Int J Tuberc Lung Dis,2017,21(12):1307-1313.[26]Long ZW,Yu HM,Wang YN,et al.Association of IL-17 polymorphisms with gastric cancer risk in Asian populations[J].World J Gastroenterol,2015,21(18):5707-5718.[27]Shao M,Xu S,Yang H,et al.Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis: A meta-analysis[J].Clin Immunol,2020(213):108374.

相似文献/References:

[1]于 洋.滑膜细胞与骨关节炎疾病的相关性研究[J].医学信息,2022,35(20):170.[doi:10.3969/j.issn.1006-1959.2022.20.047]
 YU Yang.Study on the Correlation Between Synovial Cells and Osteoarthritis Disease[J].Medical Information,2022,35(20):170.[doi:10.3969/j.issn.1006-1959.2022.20.047]
[2]吴常杰,潘 莉,谭 捷,等.膝骨关节炎患者生活质量主要维度的相关因素分析[J].医学信息,2020,33(18):59.[doi:10.3969/j.issn.1006-1959.2020.18.018]
 WU Chang-jie,PAN Li,TAN Jie,et al.Analysis of Related Factors in Main Dimensions of Quality of Life of Patients with Knee Osteoarthritis[J].Medical Information,2020,33(20):59.[doi:10.3969/j.issn.1006-1959.2020.18.018]
[3]刘泽朋,李春洪,姚志杰.单髁置换术联合关节镜治疗膝前内侧骨关节炎伴外侧半月板退变患者的疗效[J].医学信息,2020,33(22):110.[doi:10.3969/j.issn.1006-1959.2020.22.031]
 LIU Ze-peng,LI Chun-hong,YAO Zhi-jie.Efficacy of Unicondylar Knee Arthroplasty Combined with Arthroscopy in the Treatment of Knee Anteromedial Osteoarthritis with Lateral Meniscus Degeneration[J].Medical Information,2020,33(20):110.[doi:10.3969/j.issn.1006-1959.2020.22.031]
[4]潘盛强,李 宁.TLRs信号通路介导下相关因子对骨关节炎的干预机制[J].医学信息,2023,36(02):167.[doi:10.3969/j.issn.1006-1959.2023.02.037]
 PAN Sheng-qiang,LI Ning.Intervention Progress of Related Factors in Osteoarthritis Mediated by TLRs Signal Pathway[J].Medical Information,2023,36(20):167.[doi:10.3969/j.issn.1006-1959.2023.02.037]
[5]王俊瑛,周 岚,李 燕,等.单用氨基葡萄糖治疗骨关节炎有效性和安全性的Meta分析[J].医学信息,2023,36(03):119.[doi:10.3969/j.issn.1006-1959.2023.03.024]
 WANG Jun-ying,ZHOU Lan,LI Yan,et al.Meta-analysis of the Efficacy and Safety of Glucosamine Alone in the Treatment of Osteoarthritis[J].Medical Information,2023,36(20):119.[doi:10.3969/j.issn.1006-1959.2023.03.024]

更新日期/Last Update: 1900-01-01