[1]沈 仁,刘红艳,许 敏,等.脐血炎症标志物预测胎膜早破新生儿败血症的价值[J].医学信息,2021,34(20):105-107.[doi:10.3969/j.issn.1006-1959.2021.20.026]
　SHEN Ren,LIU Hong-yan,XU Min,et al.The Value of Umbilical Cord Blood Inflammatory Markers in Predicting Neonatal Sepsiswith Premature Rupture of Membranes[J].Medical Information,2021,34(20):105-107.[doi:10.3969/j.issn.1006-1959.2021.20.026]
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脐血炎症标志物预测胎膜早破新生儿败血症的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年20期
页码:
105-107
栏目:
论著
出版日期:
2021-10-20

文章信息/Info

Title:
The Value of Umbilical Cord Blood Inflammatory Markers in Predicting Neonatal Sepsiswith Premature Rupture of Membranes
文章编号:
1006-1959（2021）20-0105-03
作者:
沈 仁; 刘红艳; 许 敏; 林素琴; 蔡萍萍
玉环市人民医院新生儿科，浙江 玉环 317600
Author(s):
SHEN Ren; LIU Hong-yan; XU Min; LIN Su-qin; CAI Ping-ping
Department of Neonatology,Yuhuan People’s Hospital,Yuhuan 317600,Zhejiang,China
关键词:
白介素-6; 超敏C反应蛋白; 血清淀粉样蛋白A; 新生儿败血症; 胎膜早破
Keywords:
Interleukin-6; Hypersensitive C-reactive protein; Serum amyloid A; Neonatal sepsis; Premature rupture of membranes
分类号:
R722.13
DOI:
10.3969/j.issn.1006-1959.2021.20.026
文献标志码:
A
摘要:
目的 探讨胎膜早破产妇新生儿脐血中白介素-6（IL-6）、超敏C反应蛋白（hsCRP）、血清淀粉样蛋白A（SAA）水平在新生儿败血症早期诊断中的价值。方法 选择2019年1月-2020年7月在玉环市人民医院产科出生且母亲胎膜早破＞18 h的160例新生儿作为观察组，母亲未发生胎膜早破的80例新生儿作为对照组。两组病例均检测脐血IL-6、hsCRP和SAA水平。观察组新生儿根据是否发生新生儿败血症，分为败血症组和非败血症组，比较各组脐血IL-6、hsCRP和SAA 水平，并绘制其诊断新生儿败血症的 ROC 曲线。结果 观察组IL-6、hsCRP、SAA水高于对照组（P＜0.05）；败血症组IL-6、hsCRP 和SAA水平高于非败血症组（P＜0.05）；经ROC曲线分析显示，脐血IL-6、hsCRP、SAA及三者联合检测对诊断新生儿败血症准确性较高，曲线下面积分别为：0.943（95%CI：0.904~0.983）、0.897（95%CI：0.845~0.948）、0.885（95%CI：0.835~0.935）及0.967（95%CI：0.942~0.992）。脐血IL-6、hsCRP、SAA及三者联合检测诊断新生儿败血症的敏感度分别为76.21%、85.70%、88.11%及85.72%；特异度分别为：98.52%、80.31%、77.30%及94.42%。结论 胎膜早破产妇新生儿发生败血症风险增加，脐血IL-6、hsCRP和SAA检测有助于早期诊断新生儿败血症，其中IL-6的特异度较高，SAA的敏感度较高，三者联合检测预测新生儿败血症准确性较高。
Abstract:
Objective To investigate the value of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (SAA) in the early diagnosis of neonatal sepsis in puerpera with premature rupture of membranes.Methods A total of 160 neonates born in the Department of Obstetrics of Yuhuan People’s Hospital from January 2019 to July 2020 and whose mothers had premature rupture of membranes >18 h were selected as observation group, and 80 neonates whose mothers did not have premature rupture of membranes were selected as control group. The level of IL-6, hsCRP and SAA in cord blood were detected in both groups. The neonates in the observation group were divided into sepsis group and non-sepsis group according to whether neonatal sepsis occurred. The levels of IL-6, hsCRP and SAA in umbilical cord blood of each group were compared, and the ROC curve was drawn for the diagnosis of neonatal sepsis.Results The level of IL-6, hsCRP and SAA in the observation group were higher than those in the control group (P<0.05); the level of IL-6, hsCRP and SAA in sepsis group were higher than those in non-sepsis group (P<0.05). ROC curve analysis showed that cord blood IL-6, hsCRP, SAA and its combined detection had high accuracy in the diagnosis of neonatal sepsis, and the area under the curve was 0.943 (95%CI:0.904-0.983), 0.897(95%CI:0.845-0.948), 0.885(95%CI:0.835-0.935) and 0.967(95%CI:0.942-0.992), respectively. The sensitivity of umbilical cord blood IL-6, hsCRP, SAA and its combined detection in the diagnosis of neonatal sepsis was 76.21%, 85.70%, 88.11% and 85.72%, respectively; the specificity was 98.52%, 80.31%, 77.30% and 94.42%, respectively.Conclusion There is an increased risk of sepsis in neonates with premature rupture of membranes. The detection of umbilical cord blood IL-6, hsCRP and SAA is helpful for the early diagnosis of neonatal sepsis, among which the specificity of IL-6 is high, the sensitivity of SAA is high, and the combined detection of the three has a high accuracy in predicting neonatal sepsis.

参考文献/References:

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更新日期/Last Update: 1900-01-01