[1]李翠柳,马 洁,高 芳,等.不同糖耐量阶段女性绝经前后雌二醇与胰岛素抵抗的关系[J].医学信息,2021,34(20):112-114.[doi:10.3969/j.issn.1006-1959.2021.20.028]
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不同糖耐量阶段女性绝经前后雌二醇与胰岛素抵抗的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年20期
页码:
112-114
栏目:
论著
出版日期:
2021-10-20

文章信息/Info

Title:
The Relationship Between Estradiol and Insulin Resistance in Premenopausal andPostmenopausal Women with Different Glucose Tolerance
文章编号:
1006-1959（2021）20-0112-03
作者:
李翠柳; 马 洁; 高 芳; 王光亚; 郭宁宁; 殷秀平; 张云娜; 王霖霞
沧州市中心医院内分泌二科，河北 沧州 061000
Author(s):
LI Cui-liu; MA Jie; GAO Fang; WANG Guang-ya; GUO Ning-ning; YIN Xiu-ping; ZHANG Yun-na; WANG Lin-xia
The Second Department of Endocrinology,Cangzhou Central Hospital,Cangzhou 061000,Hebei,China
关键词:
绝经; 胰岛素抵抗; 雌二醇; 糖调节受损
Keywords:
Menopausal; Insulin resistance; Estradiol; Impaired glucose regulation
分类号:
R711
DOI:
10.3969/j.issn.1006-1959.2021.20.028
文献标志码:
A
摘要:
目的 探讨不同糖耐量阶段女性绝经前后雌二醇（E2）与胰岛素抵抗、血糖等代谢指标的关系。方法 选取2014年9月-2016年9月在我院内分泌科门诊行健康检查的328名女性为研究对象，按照是否绝经分为绝经前组（n=159）和绝经后组（n=169），绝经后组根据糖耐量状态分为正常糖耐量组（NGT组n=50）、糖调节受损组（IGR组n=70）和2型糖尿病组（T2DM组n=49）。分析绝经前后女性相关代谢指标的变化及E2与相关代谢指标的关系，以及不同糖耐量水平女性E2的变化。结果 绝经后组年龄、收缩压、LDL-C、FPG、2h PG、HbA1c、空腹胰岛素、HOMA-IR高于绝经前组，BMI、E2低于绝经前组，差异有统计学意义（P＜0.05）。两组E2水平与BMI、空腹胰岛素及HOMA-IR呈负相关（P＜0.05），与其他代谢指标无相关性（P＞0.05）。NGT组E2水平高于IGR组和T2DM组，差异有统计学意义（P＜0.05）。结论 在不同糖耐量阶段的人群中，绝经后女性的胰岛素抵抗程度明显高于绝经前女性，且女性E2水平与胰岛素抵抗呈明显负相关。
Abstract:
Objective To investigate the relationships among estradiol (E2) and insulin resistance, blood sugar and other metabolic indicators in premenopausal and postmenopausal women with different glucose tolerance.Methods A total of 328 women who underwent health examination in endocrinology clinic of our hospital from September 2014 to September 2016 were selected and divided into premenopausal group (n=159) and postmenopausal group (n=169 ) according to whether menopause or not. The postmenopausal group was divided into normal glucose tolerance group (NGT group, n=50), impaired glucose regulation group (IGR group, n=70) and type 2 diabetes group (T2DM group, n=49) according to the state of glucose tolerance. The changes of related metabolic indexes in premenopausal and postmenopausal women, the relationship between E2 and related metabolic indexes, and the changes of E2 in women with different glucose tolerance levels were analyzed.Results The Age, systolic blood pressure, LDL-C, FPG, 2h PG, HbA1c, fasting insulin and HOMA-IR in postmenopausal group were higher than those in premenopausal group, while BMI and E2 were lower than those in premenopausal group, and the difference was statistically significant (P＜0.05). The E2 levels in the two groups were negatively correlated with BMI, fasting insulin and HOMA-IR (P＜0.05), had no correlation with other metabolic indexes (P＞0.05). The E2 level in NGT group was higher than that in IGR group and T2DM group, and the difference was statistically significant (P＜0.05).Conclusions In the population with different glucose tolerance stages, the insulin resistance of postmenopausal women is significantly higher than that of premenopausal women, and the level of female E2 is significantly negatively correlated with insulin resistance.

参考文献/References:

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更新日期/Last Update: 1900-01-01