[1]蔺洪萌.胺碘酮联合西地兰治疗冠心病合并心律失常的疗效[J].医学信息,2021,34(20):161-163.[doi:10.3969/j.issn.1006-1959.2021.20.043]
 LIN Hong-meng.Effect of Amiodarone Combined with Cedilanid on Coronary Heart Disease Complicated with Arrhythmia[J].Medical Information,2021,34(20):161-163.[doi:10.3969/j.issn.1006-1959.2021.20.043]
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胺碘酮联合西地兰治疗冠心病合并心律失常的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年20期
页码:
161-163
栏目:
药物与临床
出版日期:
2021-10-20

文章信息/Info

Title:
Effect of Amiodarone Combined with Cedilanid on Coronary Heart Disease Complicated with Arrhythmia
文章编号:
1006-1959(2021)20-0161-03
作者:
蔺洪萌
天津市宁河区医院重症医学科,天津 301500
Author(s):
LIN Hong-meng
Intensive Care Unit,Tianjin Ninghe District Hospital,Tianjin 301500,China
关键词:
冠心病心律失常胺碘酮西地兰心功能
Keywords:
Coronary heart diseaseArrhythmiaAmiodaroneCedilanCardiac function
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2021.20.043
文献标志码:
A
摘要:
目的 观察胺碘酮联合西地兰治疗冠心病合并心律失常患者的疗效。方法 选取2016年1月-2020年10月我院收治的冠心病合并心律失常患者80例作为研究对象,按随机数字表法分为对照组和观察组,每组40例。对照组给予胺碘酮治疗,观察组给予胺碘酮联合西地兰治疗,比较两组临床治疗疗效、治疗前后血粘度(血浆比黏度、纤维蛋白原)、超敏C-反应蛋白(hs-CRP)、心功能指标[左心室舒张末期直径(LVEDD)、舒张早期充盈峰速度(E峰)、左心室射血分数(LVEF)]及不良反应发生情况。结果 观察组临床治疗总有效率为95.00%,高于对照组的85.00%,差异有统计学意义(P<0.05);两组治疗后血浆比黏度、纤维蛋白原和hs-CRP较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组LVEDD、E峰、LVEF均高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 胺碘酮联合西地兰治疗冠心病合并心律失常患者疗效确切,可有效改善患者心功能和血流动力学,减轻炎症反应,且联合用药不增加不良反应发生几率。
Abstract:
Objective To observe the effect of amiodarone combined with cedilanid in the treatment of coronary heart disease complicated with arrhythmia.Methods A total of 80 patients with coronary heart disease complicated with arrhythmia admitted to our hospital from January 2016 to October 2020 were selected as the research objects and divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with amiodarone, and the observation group was treated with amiodarone combined with cedilanid. The clinical efficacy, blood viscosity (plasma viscosity, fibrinogen), high-sensitivity C-reactive protein (hs-CRP), cardiac function indexes [left ventricular end-diastolic diameter (LVEDD), early diastolic filling peak velocity (E peak), left ventricular ejection fraction (LVEF)] and adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 95.00%, which was higher than 85.00% in the control group, and the difference was statistically significant (P<0.05). The plasma specific viscosity, fibrinogen and hs-CRP of the two groups after treatment were lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). The LVEDD, Epeak and LVEF in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Amiodarone combined with cedilanid is effective in the treatment of patients with coronary heart disease complicated with arrhythmia, which can effectively improve cardiac function and hemodynamics, reduce inflammatory response, and the combination does not increase the probability of adverse reactions.

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更新日期/Last Update: 1900-01-01