[1]刘婕妤,杨文杰,赵学群.T淋巴细胞亚群对鲍曼不动杆菌感染与定植的诊断价值[J].医学信息,2021,34(20):167-169.[doi:10.3969/j.issn.1006-1959.2021.20.045]
 LIU Jie-yu,YANG Wen-jie,ZHAO Xue-qun.Diagnostic Value of T Lymphocyte Subsets in Acinetobacter Baumannii Infection and Colonization[J].Medical Information,2021,34(20):167-169.[doi:10.3969/j.issn.1006-1959.2021.20.045]
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T淋巴细胞亚群对鲍曼不动杆菌感染与定植的诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年20期
页码:
167-169
栏目:
诊疗技术
出版日期:
2021-10-20

文章信息/Info

Title:
Diagnostic Value of T Lymphocyte Subsets in Acinetobacter Baumannii Infection and Colonization
文章编号:
1006-1959(2021)20-0167-03
作者:
刘婕妤杨文杰赵学群
天津市第一中心医院感染科,天津 300000
Author(s):
LIU Jie-yuYANG Wen-jieZHAO Xue-qun
Department of Infection,Tianjin First Central Hospital,Tianjin 300000,China
关键词:
T淋巴细胞亚群鲍曼不动杆菌获得性肺炎
Keywords:
T lymphocyte subsetsAcinetobacter baumanniiAcquired pneumonia
分类号:
R446.5
DOI:
10.3969/j.issn.1006-1959.2021.20.045
文献标志码:
A
摘要:
目的 分析T淋巴细胞亚群对鲍曼不动杆菌(AB)感染与定植的鉴别诊断效果。方法 选取2018年1月-2021年2月我院经痰培养分离出AB的80例患者作为研究对象,其中定植组45例,感染组35例,比较两组T淋巴细胞亚群水平,并分析AB感染与T淋巴细胞亚群水平的相关性及影响因素。结果 两组CD3+、CD4+比较,差异无统计学意义(P>0.05);两组CD4+/CD8+、IL-2、IL-4、IL-17、TNF-α、IFN-γ比较,差异有统计学意义(P<0.05)。Spearman相关分析显示,AB感染与TNF-α、IFN-γ、IL-2、IL-4及IL-17呈正相关(r=0.302、0.243、0.305、0.259、0.495,P=0.011、0.018、0.009、0.008、0.000),与CD4+/CD8+呈负相关(r=-0.295,P=0.000)。多因素Logistic回归分析显示,CD4+/CD8+、IL-17以及IFN-γ是AB感染的高危因素。结论 T淋巴细胞亚群在AB感染与定植中具有一定的参考价值,可作为临床鉴别诊断的重要指标。
Abstract:
Objective To analyze the diagnostic value of T lymphocyte subsets in Acinetobacter baumannii (AB) infection and colonization.Methods A total of 80 patients with AB isolated by sputum culture in our hospital from January 2018 to February 2021 were selected as the research objects, including 45 patients in the colonization group and 35 patients in the infection group. The levels of T lymphocyte subsets in the two groups were compared, and the correlation between AB infection and T lymphocyte subsets and its influencing factors were analyzed.Results There was no significant difference in CD3+ and CD4+ between the two groups (P>0.05), there were statistically significant differences in CD4+/CD8+, IL-2, IL-4, IL-17, TNF-α and IFN-γ between the two groups (P<0.05). Spearman correlation analysis showed that AB infection was positively correlated with TNF-α, IFN-γ, IL-2, IL-4 and IL-17 (r=0.302, 0.243, 0.305, 0.259, 0.495, P=0.011, 0.018, 0.009, 0.008, 0.000), and negatively correlated with CD4+/CD8+ (r=-0.295, P=0.000). Multivariate logistic regression analysis showed that CD4+/CD8+, IL-17 and IFN-γ were high risk factors for AB infection.Conclusion T lymphocyte subsets have a certain reference value in AB infection and colonization, which can be used as an important indicator for clinical differential diagnosis.

参考文献/References:

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更新日期/Last Update: 1900-01-01