[1]谢招莲,刘琳琳,吴维霖.不含防腐剂的玻璃酸钠联合氟米龙滴眼液治疗白内障伴干眼的对照研究[J].医学信息,2021,34(22):69-71.[doi:10.3969/j.issn.1006-1959.2021.22.020]
　XIE Zhao-lian,LIU Lin-lin,WU Wei-lin.A Comparative Study of Sodium Hyaluronate Without Preservatives Combined with Fluorometholone Eye Drops in the Treatment of Cataract with Dry Eye[J].Medical Information,2021,34(22):69-71.[doi:10.3969/j.issn.1006-1959.2021.22.020]
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不含防腐剂的玻璃酸钠联合氟米龙滴眼液治疗白内障伴干眼的对照研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年22期
页码:
69-71
栏目:
论著
出版日期:
2021-11-15

文章信息/Info

Title:
A Comparative Study of Sodium Hyaluronate Without Preservatives Combined with Fluorometholone Eye Drops in the Treatment of Cataract with Dry Eye
文章编号:
1006-1959（2021）22-0069-03
作者:
谢招莲; 刘琳琳; 吴维霖
（赣南医学院第一附属医院眼科，江西 赣州 341000）
Author(s):
XIE Zhao-lian; LIU Lin-lin; WU Wei-lin
(Department of Ophthalmology,the First Affiliated Hospital of Gannan Medical College,Ganzhou 341000,Jiangxi,China)
关键词:
防腐剂; 玻璃酸钠; 氟米龙滴眼液; 白内障; 干眼
Keywords:
Preservatives; Sodium hyaluronate; Flumeuron eye drops; Cataract; Dry eye
分类号:
R988.1
DOI:
10.3969/j.issn.1006-1959.2021.22.020
文献标志码:
A
摘要:
目的 观察不含防腐剂的玻璃酸钠联合氟米龙滴眼液治疗白内障伴干眼的临床疗效。方法 选取2020年1月-2021年8月在我院诊治的84例白内障伴干眼患者为研究对照组，采用随机数字表法分为对照组和观察组，各42例。对照组采用不含防腐剂的玻璃酸钠滴眼液治疗，观察组在对照组基础上给予氟米龙滴眼液治疗，比较两组临床治疗总有效率、泪膜破裂时间（BUT）、基础泪液分泌试验（SIt）值、角膜荧光素染色评分、干眼症状评分、不良反应发生情况。结果 观察组治疗总有效率为95.23%，高于对照组的83.33%（P＜0.05）；治疗后两组BUT、SIt均大于治疗前，角膜荧光素染色评分均小于治疗前，且观察组BUT、SIt均大于，角膜荧光素染色评分小于对照组（P＜0.05）；观察组眼部疼痛或刺激感、干涩感、烧灼感或流泪、异物感评分均低于对照组（P＜0.05）；观察组不良反应发生率为7.14%，低于对照组的16.67%（P＜0.05）。结论 不含防腐剂的玻璃酸钠联合氟米龙滴眼液治疗白内障伴干眼效果确切，降低临床干眼症评分，改善言功能指标，降低临床不良反应，相对是一种安全、有效的治疗方法。
Abstract:
Objective To observe the clinical efficacy of sodium hyaluronate without preservatives combined with fluorometholone eye drops in the treatment of cataract with dry eye.Methods A total of 84 patients with cataract and dry eye treated in our hospital from January 2020 to August 2021 were selected as the study control group. They were divided into control group and observation group by random number table method, with 42 cases in each group. The control group was treated with sodium hyaluronate eye drops without preservatives, and the observation group was treated with fluorometholone eye drops on the basis of the control group. The total effective rate of clinical treatment, tear break-up time (BUT), basic tear Schirmer’s-I test (SIt), the scores of cornea fluorescein staining, dry eye symptom score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.23%, which was higher than 83.33% in the control group (P<0.05). After treatment, BUT and SIt in the two groups were higher than those before treatment, FLS was lower than that before treatment, and BUT and SIt in the observation group were higher than those in the control group, the scores of cornea fluorescein staining was lower than that in the control group (P<0.05). The scores of eye pain or irritation, dryness, burning sensation or tears and foreign body sensation in the observation group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 7.14%, which was lower than 16.67% in the control group (P<0.05).Conclusion Sodium hyaluronate without preservatives combined with fluorometholone eye drops is effective in the treatment of cataract with dry eye. It is relatively a safe and effective treatment method to reduce the clinical dry eye score, improve speech function index and reduce clinical adverse reactions.

参考文献/References:

[1]徐良,丁亚莉.0.1%溴芬酸钠水合物滴眼液在中重度干眼治疗中的应用[J].中国实用眼科杂志,2017,35(9):906-908.[2]姜志东,张晶,张国升.奥洛他定联合氟米龙与奥洛他定单独治疗过敏性结膜炎疗效比较[J].中国社区医师,2019,35(9):25-26.[3]银哲,银锐,李元彬,等.不含防腐剂的玻璃酸钠联合氟米龙滴眼液治疗白内障伴干眼的随机单盲对照研究[J].中华实验眼科杂志,2017,35(9):843-847.[4]肖迟.玻璃酸钠滴眼液联合0.02%氟米龙滴眼液治疗急性结膜炎后干眼症的临床效果[J].中国药物经济学,2018,13(5):72-74.[5]李芳,刘月君,邓小芬.玻璃酸钠联合复明胶囊治疗白内障术后干眼症的临床观察[J].安徽医药,2017,21(12):2295-2298.[6]靳素娟.玻璃酸钠联合rhEGF滴眼液治疗白内障术后干眼症泪膜的临床效果[J].临床医学,2018(12):111-112.[7]朱秋健,邢潇英,吴作志,等.四种常见人工泪液对白内障术后干眼患者泪液动力学变化影响的差异[J].中国实用眼科杂志,2017,35(9):899-902.[8]李孟石,乔军辉,武天坤.玻璃酸钠联合rhEGF滴眼液治疗白内障术后干眼症泪膜的效果及对泪液TNF-α、IL-6水平影响[J].现代诊断与治疗,2017(9):10-11.[9]党秀红.玻璃酸钠联合rhEGF滴眼液在白内障术后干眼症中的应用[J].中国继续医学教育,2018,10(19):135-136.[10]郑晓红,赵少贞.质量分数0.1%和0.3%玻璃酸钠滴眼液对FSLASIK术后干眼泪膜稳定性及视觉质量的影响[J].中华实验眼科杂志,2018,36(5):373-379.[11]杜慧斌,胡卜丹,卢建群,等.玻璃酸钠联合氟米龙治疗睑板腺功能障碍引起的干眼60例[J].医学信息,2016,29(36):131-132.[12]Beck R,Stachs O,Koschmieder A,et al.Hyaluronic Acid as an Alternative to Autologous Human Serum Eye Drops: Initial Clinical Results with High-Molecular-Weight Hyaluronic Acid Eye Drops[J].Case Rep Ophthalmol,2019,10(2):244-255.[13]吴胜卫,孙冉,张健,等.伴有葡萄膜炎的白内障术后药物治疗的效果[J].中华眼外伤职业眼病杂志,2019,41(5):337-343.[14]曹慧琴.普拉洛芬滴眼液用于白内障超声乳化术后改善干眼、眼压以及矫正视力的效果探讨[J].实用防盲技术,2017,12(1):10-12.[15]滕荣建,叶锌铭,张丽娜,等.玻璃酸钠滴眼液联合重组人表皮生长因子滴眼液治疗白内障术后干眼症的疗效观察[J].药物流行病学杂志,2017(8):13-15.[16]陈海兵,陈荥培,王树奎.普拉洛芬联合玻璃酸钠滴眼液在白内障术后干眼症治疗中的临床效果[J].现代实用医学,2018(12):101-102.[17]范伟杰,赵峰.普拉洛芬联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼疗效观察[J].中国药业,2018,27(21):70-72.[18]Tang Y,Tan J,Zhou X,et al.Modified phacoemulsification plus goniosynechialysis compared with conventional surgery for cataract and glaucoma[J].Exp Ther Med,2020,19(1):131-136.[19]嵇晔,金辉,方娜.石斛夜光丸联合玻璃酸钠滴眼液治疗干眼症临床及安全性评估[J].中华中医药学刊,2019,37(8):1970-1973.[20]朱江,李石磊,黄振平.氟米龙滴眼液联合玻璃酸钠滴眼液治疗系统性红斑狼疮相关干眼疗效观察[J].临床眼科杂志,2018,26(1):68-72.

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更新日期/Last Update: 1900-01-01