[1]王启龙,张 蔚.支气管哮喘急性发作并肺部感染患者血清炎性因子、免疫球蛋白水平与预后的相关性分析[J].医学信息,2021,34(22):81-83.[doi:10.3969/j.issn.1006-1959.2021.22.024]
　WANG Qi-long,ZHANG Wei.Correlation Analysis of Serum Inflammatory Factors, Immunoglobulin Levels and Prognosis in Patients with Acute Exacerbation of Bronchial Asthma Complicated with Pulmonary Infection[J].Medical Information,2021,34(22):81-83.[doi:10.3969/j.issn.1006-1959.2021.22.024]
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支气管哮喘急性发作并肺部感染患者血清炎性因子、免疫球蛋白水平与预后的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年22期
页码:
81-83
栏目:
论著
出版日期:
2021-11-15

文章信息/Info

Title:
Correlation Analysis of Serum Inflammatory Factors, Immunoglobulin Levels and Prognosis in Patients with Acute Exacerbation of Bronchial Asthma Complicated with Pulmonary Infection
文章编号:
1006-1959（2021）22-0081-03
作者:
王启龙; 张 蔚
（邳州市人民医院检验科，江苏 邳州 221300）
Author(s):
WANG Qi-long; ZHANG Wei
(Department of Laboratory,Pizhou People’s Hospital,Pizhou 221300,Jiangsu,China)
关键词:
支气管哮喘; 急性发作期; 肺部感染; 免疫球蛋白; 炎症因子
Keywords:
Bronchial asthma; Acute attack period; Pulmonary infection; Immunoglobulin; Inflammatory factors
分类号:
R562.25；R563.1
DOI:
10.3969/j.issn.1006-1959.2021.22.024
文献标志码:
A
摘要:
目的 分析支气管哮喘急性发作并肺部感染患者血清炎性因子、免疫球蛋白水平与预后的相关性。方法 选取本院2018年1月-2020年1月收治的80例支气管哮喘急性发作并肺部感染患者（观察组）和80名健康志愿者（对照组）作为研究对象。观察组患者实施规范化治疗，比较两组血清白细胞介素-33（IL-33）、免疫球蛋白E（IgE）水平及肺功能，并分析IL-33、IgE与患者肺功能及预后的关系。结果 观察组血清IL-33、IgE水平高于对照组，差异有统计学意义（P＜0.05）；观察组的IL-33、IgE、FEV1、FEV1%pred及FEV1/FVC水平均较治疗前降低，差异有统计学意义（P＜0.05）；不同严重程度支气管哮喘患者的IL-33、IgE水平比较，表现为轻度＜中度＜重度，差异有统计学意义（P＜0.05）；血清IL-33、IgE均与FEV1、FEV1%pred、FEV1/FVC均呈负相关（P＜0.05）；预后不良的患者血清IL-33和IgE水平高于预后良好的患者，差异有统计学意义（P＜0.05）。结论 支气管哮喘急性发作并肺部感染患者血清IL-33及IgE水平越高，预示着患者的肺功能及预后状况越差。
Abstract:
Objective To analyze the correlation between serum inflammatory factors, immunoglobulin levels and prognosis in patients with acute exacerbation of bronchial asthma complicated with pulmonary infection.Methods A total of 80 patients with acute exacerbation of bronchial asthma complicated with pulmonary infection (observation group ) and 80 healthy volunteers (control group) admitted to our hospital from January 2018 to January 2020 were selected as subjects. The patients in the observation group were treated with standardized treatment. The levels of serum interleukin-33 (IL-33), immunoglobulin E (IgE) and lung function were compared between the two groups, and the relationship between IL-33, IgE and lung function and prognosis were analyzed.Results The levels of serum IL-33 and IgE in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The levels of IL-33, IgE, FEV1, FEV1% pred and FEV1/FVC in the observation group were lower than those before treatment, and the difference was statistically significant (P<0.05). The levels of IL-33 and IgE in patients with bronchial asthma at different severity levels were compared, showing mild

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更新日期/Last Update: 1900-01-01