[1]周 涛.Ⅱ、Ⅲ期直肠癌Ki-67及微卫星不稳定的表达对预后的影响[J].医学信息,2021,34(23):66-68.[doi:10.3969/j.issn.1006-1959.2021.23.018]
　ZHOU Tao.Effect of Ki-67 and Microsatellite Instability on Prognosis in Stage Ⅱ and Ⅲ Rectal Cancer[J].Medical Information,2021,34(23):66-68.[doi:10.3969/j.issn.1006-1959.2021.23.018]
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Ⅱ、Ⅲ期直肠癌Ki-67及微卫星不稳定的表达对预后的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
66-68
栏目:
论著
出版日期:
2021-12-01

文章信息/Info

Title:
Effect of Ki-67 and Microsatellite Instability on Prognosis in Stage Ⅱ and Ⅲ Rectal Cancer
文章编号:
1006-1959（2021）23-0066-03
作者:
周 涛
（泰州市第二人民医院普外科，江苏 泰州 225500）
Author(s):
ZHOU Tao
(Department of General Surgery,Taizhou Second People’s Hospital,Taizhou 225500,Jiangsu,China)
关键词:
直肠癌; 微卫星不稳定性; Ki-67; 预后
Keywords:
Rectal cancer; Microsatellite instability; Ki-67; Prognosis
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2021.23.018
文献标志码:
A
摘要:
目的 分析Ⅱ、Ⅲ期直肠癌Ki-67及微卫星不稳定的表达对预后的影响。方法 将我院2019年3月-2021年3月共65例结肠癌患者作为研究对象，分析错配修复蛋白表达情况、微卫星不稳定性与直肠癌临床特征、生存期之间的关系以及Ki-67与直肠癌临床特征、生存期之间的关系。结果 MLH1表达缺失11例，MSH2表达缺失14例，MSH6表达缺失8例，PMS2表达缺失7例。Ki-67表达阳性48例，阴性17例。微卫星不稳定性与肿瘤直径、淋巴结转移以及TNM分期有关（P＜0.05）；微卫星不稳定性患者总生存期高于微卫星稳定性患者（P＜0.05）；Ki-67与肿瘤直径、淋巴结转移以及TNM分期有关（P＜0.05）；Ki-67阳性患者总生存期高于Ki-67阴性患者（P＜0.05）。结论 Ki-67阴性及微卫星不稳定表达有利于延长Ⅱ、Ⅲ期直肠癌患者的总生存期，主要与肿瘤直径、淋巴结转移、TNM分期有关。
Abstract:
Objective To analyze the effects of Ki-67 and microsatellite instability on the prognosis of stage Ⅱ and Ⅲ rectal cancer.Methods A total of 65 colon cancer patients in our hospital from March 2019 to March 2021 were used as the research objects to analyze the expression of mismatch repair proteins, the relationship between microsatellite instability and the clinical characteristics of rectal cancer, survival, and the relationship between Ki-67 and rectal cancer clinical features and survival period.Results There were 11 cases of MLH1 expression loss, 14 cases of MSH2 expression loss, 8 cases of MSH6 expression loss, and 7 cases of PMS2 expression loss. Ki-67 expression was positive in 48 cases and negative in 17 cases. Microsatellite instability was related to tumor diameter, lymph node metastasis and TNM stage (P<0.05). The total survival time of patients with microsatellite instability was higher than patients with microsatellite instability (P<0.05). Ki-67 was related to tumor diameter, lymph node metastasis and TNM stage (P<0.05). The total survival time of Ki-67 positive patients was higher than that of Ki-67 negative patients (P<0.05).Conclusion Ki-67 negative and microsatellite instability expression are conducive to prolonging the overall survival of patients with stage Ⅱ and Ⅲ rectal cancer, which are mainly related to tumor diameter, lymph node metastasis and TNM staging.

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更新日期/Last Update: 1900-01-01