[1]范文芳,刘起江.缩宫素联合分娩镇痛对产妇宫颈成熟度及机体应激状态的影响[J].医学信息,2021,34(23):108-110.[doi:10.3969/j.issn.1006-1959.2021.23.031]
　FAN Wen-fang,LIU Qi-jiang.Effect of Oxytocin Combined with Labor Analgesia on Cervical Maturity and Stress State of Parturients[J].Medical Information,2021,34(23):108-110.[doi:10.3969/j.issn.1006-1959.2021.23.031]
点击复制

缩宫素联合分娩镇痛对产妇宫颈成熟度及机体应激状态的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
108-110
栏目:
论著
出版日期:
2021-12-01

文章信息/Info

Title:
Effect of Oxytocin Combined with Labor Analgesia on Cervical Maturity and Stress State of Parturients
文章编号:
1006-1959（2021）23-0108-03
作者:
范文芳; 刘起江
（丰城市妇幼保健院妇产科1，检验科2，江西 丰城 331100）
Author(s):
FAN Wen-fang; LIU Qi-jiang
(Department of Obstetrics and Gynecology1,Department of Laboratory2,Fengcheng Maternal and Child Health Hospital,Fengcheng 331100,Jiangxi,China)
关键词:
缩宫素; 分娩镇痛; 宫颈成熟度
Keywords:
Oxytocin; Labor analgesia; Cervical maturity
分类号:
R714.3
DOI:
10.3969/j.issn.1006-1959.2021.23.031
文献标志码:
A
摘要:
目的 分析缩宫素联合分娩镇痛对产妇宫颈成熟度及机体应激状态的影响。方法 选择2019年3月-2021年3月我院收治的68例产妇作为研究对象，按照生产干预实施方式不同分为对照组和观察组，每组34例。对照组采用分娩镇痛方法进行生产，观察组采取缩宫素结合分娩镇痛方法进行生产，比较两组不同时点[镇痛前（T0）、宫口全部开3 cm时（T1）、宫口全部开3 cm时后1 h（T2）、胎儿娩出时（T3）]宫颈成熟度评分、宫颈分泌物成熟度相关指标[活性胎儿纤连结合蛋白（fFN）、胰岛素样生长因子结合蛋白-1（IGFBP-1）及白细胞介素-6（IL-6）]、机体应激指标[血清皮质醇（Cor）、去肾上腺素（NE）、肾上腺素（ADR）、促肾上腺皮质激素（ACTH）]。结果 两组T1、T2时点不同宫颈成熟度评分占比比较，差异有统计学意义（P＜0.05）；观察组T1、T2时点fFN、IGFBP-1、IL-6高于对照组，差异有统计学意义（P＜0.05）；观察组T1、T2、T3时点Cor、NE、ADR、ACTH低于对照组，差异有统计学意义（P＜0.05）。结论 缩宫素联合分娩镇痛可有效改善产妇宫颈成熟度及机体应激状态。
Abstract:
Objective To analyze the effect of oxytocin combined with labor analgesia on maternal cervical maturity and body stress state.Methods A total of 68 puerpera admitted to our hospital from March 2019 to March 2021 were selected as the research objects. According to the different implementation methods of production intervention, they were divided into control group and observation group, with 34 cases in each group. The control group was given labor analgesia, while the observation group was given oxytocin combined with labor analgesia. The cervical maturity score, cervical secretion maturity related indicators [active fetal fibronectin (fFN), insulin-like growth factor binding protein-1 (IGFBP-1) and interleukin-6 (IL-6)] and body stress indicators [serum cortisol (Cor), norepinephrine (NE), epinephrine (ADR), adrenocorticotropic hormone (ACTH)] were compared between the two groups at different time points [before analgesia (T0), when the cervix was opened 3 cm (T1), 1 h after the cervix was opened 3 cm (T2), and at the time of fetal delivery (T3)].Results There was statistically significant difference in the proportions of different cervical maturity scores at T1 and T2 between the two groups (P<0.05). The levels of fFN, IGFBP-1 and IL-6 at T1 and T2 in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).The levels of Cor, NE, ADR and ACTH at T1, T2 and T3 in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05).Conclusion Oxytocin combined with labor analgesia can effectively improve maternal cervical maturity and body stress state.

参考文献/References:

[1]乔建军,张志芳,朱海琴,等.腰-硬联合与单纯硬膜外阻滞麻醉在分娩镇痛中的比较[J].中国妇幼保健,2015,30(30):5281-5283.[2]孙蓉蓉,张文淼,李冬,等.新产程标准下分娩镇痛对初产妇产程的影响[J].现代实用医学,2020,32(10):48-50.[3]王志勇,曹树军.硬膜外麻醉联合全程小剂量缩宫素在镇痛分娩中的应用效果观察[J].中国妇幼保健,2018,33(12):2812-2814.[4]王平,沈刚,银光华.小剂量缩宫素静滴辅助多模式分娩镇痛在初产妇中的临床应用效果[J].山东医药,2020,60(36):3.[5]中华医学会.临床诊疗指南:妇产科学分册[M].北京:人民卫生出版社,2007:162.[6]宗银东,聂颖,姜义铁,等.罗哌卡因硬膜外患者自控镇痛的无痛分娩效果及应激反应的临床研究[J].重庆医学,2016,45(7):2407-2409.[7]许勇,李平.不同浓度罗哌卡因复合舒芬太尼经硬膜外腔用于不同时点分娩镇痛的临床观察[J].中国临床医生杂志,2017,45(9):84-86.[8]黄昕,李赛.第三产程中催产素联合气囊腹压带预防分娩镇痛产妇产后出血的效果观察[J].中国计划生育学杂志,2019,27(3):371-373,378.[9]丁其培,王琛琛,陈薇,等.IGFBP-1、MMP-9、HCG在足月胎膜早破诊断中的临床意义[J].检验医学与临床,2018,15(8):1101-1104.[10]Singer J,Jank A,Amara S,et al.Eficacy and fleets of parenteralpethidine or meplazinol and regional analgesia for pain relief duringdelivery.A comparative observational study[J].Geburtshilfe Frauenheilkd,2016,76(9):964-971.[11]张弓.罗哌卡因腰硬联合麻醉用于分娩镇痛的效果及对母婴的影响[J].中国基层医药，2018,25(20):2657-2659.[12]李小玲.缩宫素联合卡前列素氨丁三醇注射液对瘢痕子宫剖宫产产后出血的影响[J].中国当代医药,2020,27(13):74-76.[13]刘晓芳.剖宫产后联合应用缩宫素注射液与欣母沛预防产后出血的效果分析[J].临床医学,2021,41(8):106-108.[14]Bernhard A,Kirchner M,Martinelli A,et al.Sex-specific associations of basal steroid hormones and neuropeptides with Conduct Disorder and neuroendocrine mediation of environmental risk[J].Eur Neuropsychopharmacol,2021(49):40-53. [15]Grieb ZA,Ford EG,Yagan M,et al.Oxytocin receptors in the midbrain dorsal raphe are essential for postpartum maternal social and affective behaviors[J].Psychoneuroendocrinology,2021(131):105332.

相似文献/References:

[1]欧圣华.自由体位联合分娩镇痛仪在产程中的应用研究[J].医学信息,2018,31(05):176.[doi:10.3969/j.issn.1006-1959.2018.05.065]
　OU Sheng-hua.Study on the Application of Free Body Position Combined with Labor Analgesia Instrument in Labor Process[J].Medical Information,2018,31(23):176.[doi:10.3969/j.issn.1006-1959.2018.05.065]
[2]杨 莹.分娩镇痛联合体位护理对产妇产程及镇痛效果的影响[J].医学信息,2022,35(09):178.[doi:10.3969/j.issn.1006-1959.2022.09.046]
　YANG Ying.Effect of Combined Position Nursing for Labor Analgesia on Labor Process and Analgesic Effect of Puerpera[J].Medical Information,2022,35(23):178.[doi:10.3969/j.issn.1006-1959.2022.09.046]
[3]陈登宏.COOK宫颈扩张球囊与缩宫素促宫颈成熟引产的临床观察[J].医学信息,2018,31(15):91.[doi:10.3969/j.issn.1006-1959.2018.15.028]
　CHEN Deng-hong.Clinical Observation of COOK Cervical Dilatation Balloon and Oxytocin for Promoting Cervical Ripening Induced Labor[J].Medical Information,2018,31(23):91.[doi:10.3969/j.issn.1006-1959.2018.15.028]
[4]王振山,李艳丽,李晓娟,等.不同浓度罗哌卡因应用于分娩镇痛的临床观察[J].医学信息,2019,32(02):154.[doi:10.3969/j.issn.1006-1959.2019.02.046]
　WANG Zhen-shan,LI Yan-li,LI Xiao-juan,et al.Clinical Observation of Different Concentrations of Ropivacaine for Labor Analgesia[J].Medical Information,2019,32(23):154.[doi:10.3969/j.issn.1006-1959.2019.02.046]
[5]宋晓娟.缩宫素与COOK双球囊在促进宫颈成熟合并引产的临床对比研究[J].医学信息,2018,31(19):117.[doi:10.3969/j.issn.1006-1959.2018.19.035]
　SONG Xiao-juan.Clinical Comparative Study of Oxytocin and COOK Double Balloon in Promoting Cervical Ripening and Induction of Labor[J].Medical Information,2018,31(23):117.[doi:10.3969/j.issn.1006-1959.2018.19.035]
[6]赵 静.潜伏期行椎管内阻滞麻醉分娩镇痛对孕妇分娩结局及 新生儿预后的影响[J].医学信息,2019,32(12):107.[doi:10.3969/j.issn.1006-1959.2019.12.033]
　ZHAO Jing.Effect of Analgesia during Labor in the Incubation Period on the Outcome of Delivery and Prognosis of Pregnant Women[J].Medical Information,2019,32(23):107.[doi:10.3969/j.issn.1006-1959.2019.12.033]
[7]何华东.罗哌卡因复合瑞芬太尼腰麻-硬膜外麻醉在分娩镇痛中的价值[J].医学信息,2022,35(17):57.[doi:10.3969/j.issn.1006-1959.2022.17.013]
　HE Hua-dong.The Value of Ropivacaine with Remifentanil Combined Spinal-epidural Anesthesia in Labor Analgesia[J].Medical Information,2022,35(23):57.[doi:10.3969/j.issn.1006-1959.2022.17.013]
[8]李晓君.麦角新碱联合米索前列醇、缩宫素在胎盘早剥产后大出血的临床效果及对应激反应的影响[J].医学信息,2023,36(19):141.[doi:10.3969/j.issn.1006-1959.2023.19.031]
　LI Xiao-jun.Clinical Effect of Ergometrine Combined with Misoprostol and Oxytocin in Postpartum Hemorrhage of Placental Abruption and its Effect on Stress Response[J].Medical Information,2023,36(23):141.[doi:10.3969/j.issn.1006-1959.2023.19.031]
[9]李炳良.罗哌卡因复合瑞芬太尼腰麻-硬膜外麻醉在分娩镇痛中的应用价值[J].医学信息,2022,35(18):57.[doi:10.3969/j.issn.1006-1959.2022.18.013]
　LI Bing-liang.Application Value of Ropivacaine Combined with Remifentanil Spinal-epidural Anesthesia in Labor Analgesia[J].Medical Information,2022,35(23):57.[doi:10.3969/j.issn.1006-1959.2022.18.013]
[10]刘邦精.硬膜外间歇注药对产妇运动功能和分娩结局的影响[J].医学信息,2022,35(19):65.[doi:10.3969/j.issn.1006-1959.2022.19.017]
　LIU Bang-jing.Effect of Intermittent Epidural Injection on Maternal Motor Function and Delivery Outcome[J].Medical Information,2022,35(23):65.[doi:10.3969/j.issn.1006-1959.2022.19.017]

更新日期/Last Update: 1900-01-01