[1]刘细风.甲氨蝶呤联合米非司酮治疗不同β-hCG水平宫外孕患者的效果[J].医学信息,2021,(24):138-140.[doi:10.3969/j.issn.1006-1959.2021.24.035]
 LIU Xi-feng.Effect of Methotrexate Combined with Mifepristone in the Treatment of Ectopic Pregnancy with Different β-hCG Levels[J].Medical Information,2021,(24):138-140.[doi:10.3969/j.issn.1006-1959.2021.24.035]
点击复制

甲氨蝶呤联合米非司酮治疗不同β-hCG水平宫外孕患者的效果()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2021年24期
页码:
138-140
栏目:
药物与临床
出版日期:
2021-12-15

文章信息/Info

Title:
Effect of Methotrexate Combined with Mifepristone in the Treatment of Ectopic Pregnancy with Different β-hCG Levels
文章编号:
1006-1959(2021)24-0138-03
作者:
刘细风
(永新县妇幼保健院妇科,江西 永新 343400)
Author(s):
LIU Xi-feng
(Department of Gynecology,Yongxin County Maternal and Child Health Hospital,Yongxin 343400,Jiangxi,China)
关键词:
宫外孕甲氨蝶呤米非司酮β-hCG孕酮
Keywords:
Ectopic pregnancyMethotrexateMifepristoneβ-hCGProgesterone
分类号:
R714.22
DOI:
10.3969/j.issn.1006-1959.2021.24.035
文献标志码:
A
摘要:
目的 研究甲氨蝶呤联合米非司酮治疗不同人绒毛膜促性腺激素(β-hCG)水平宫外孕患者的临床效果。方法 选取2018年10月-2021年3月永新县妇幼保健院妇科收治的60例宫外孕患者,按照β-hCG水平的不同分为A组(β-hCG≤2000 U/L)、B组(2000 U/L<β-hCG≤5000 U/L)、C组(β-hCG>5000 U/L),均采用甲氨蝶呤联合米非司酮治疗,比较三组治疗效果、孕酮水平、妊娠包块直径、症状消失时间、血β-hCG恢复时间、妊娠包块消失时间、转手术率、输卵管复通率及不良反应。结果 三组治疗总有效率、孕酮水平、妊娠包块直径、症状消失时间、血β-hCG恢复时间、妊娠包块消失时间、转手术率、输卵管复通率及不良反应总发生率比较,差异有统计学意义(P<0.05)。结论 甲氨蝶呤联合米非司酮对不同β-hCG水平的宫外孕患者均具有确切疗效,且血β-hCG水平越低,效果越明显,安全性越高。
Abstract:
Objective To study the clinical effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy with different human chorionic gonadotropin (β-hCG) levels.Methods A total of 60 patients with ectopic pregnancy admitted to Department of Gynecology, Yongxin Maternal and Child Health Hospital from October 2018 to March 2021 were divided into group A (β-hCG≤ 2000 U/L), group B (2000 U/L<β-hCG≤5000 U/L) and group C (β-hCG>5000 U/L) according to the different levels of β-hCG. All groups were treated with methotrexate combined with mifepristone. The therapeutic effect, progesterone level, gestational mass diameter, symptom disappearance time, blood β-hCG recovery time, gestational mass disappearance time, conversion rate, fallopian tube recanalization rate and adverse reactions were compared among the three groups.Results There were significant differences in the total effective rate, progesterone level, pregnancy mass diameter, symptom disappearance time, blood β-hCG recovery time, pregnancy mass disappearance time, operation rate, fallopian tube recanalization rate and total incidence of adverse reactions among the three groups (P<0.05).Conclusion The combination of methotrexate and mifepristone has a definite effect on patients with different β-hCG levels of ectopic pregnancy, and the lower the blood β-hCG level, the more obvious the effect and the higher the safety.

参考文献/References:

[1]龙彬宜.甲氨蝶呤联合米非司酮治疗宫外孕的效果及对血清孕酮、β-hCG水平的影响[J].临床合理用药杂志,2020,13(29):87-88.[2]廖婧文,林少敏,陈芳敏.米非司酮联合甲氨蝶呤保守治疗宫外孕临床疗效及对β-hCG、CA125表达的影响[J].北方药学,2020,17(3):21-22.[3]徐保华.米非司酮联合甲氨蝶呤保守治疗对宫外孕患者的效果及性功能的影响[J].黑龙江中医药,2019,48(3):188-189.[4]徐芳,谢秀梅,党晓贤.甲氨蝶呤+米非司酮治疗对宫外孕患者体重指数、血浆D-D及β-HCG水平的影响[J].临床医学研究与实践,2019,4(17):80-82.[5]李常虹,黄赞怡,王琼.甲氨蝶呤联合米非司酮治疗宫外孕对患者血清孕酮β-HCG水平影响分析[J].河北医学,2019,25(4):563-567.[6]Zhang J,Zhang Y,Gan L,et al.Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy[J].BMC Pregnancy Childbirth,2020,20(1):654.[7]邢小娟,王素琴.米非司酮与甲氨喋呤联合治疗宫外孕临床效果观察[J].北方药学,2019,16(3):121-122.[8]高玉婷,谢雯,黄帝.超声检查联合血清中β-HCG水平在宫外孕患者中的临床运用[J].解放军预防医学杂志,2018,36(10):1323-1325.[9]Dai Y,Zhang G,Lan ZM,et al.Routine β-Human Chorionic Gonadotropin Monitoring for Single-Dose Methotrexate Treatment in Ectopic Pregnancy-ScienceDirect[J].J Minim Invasive Gynecol,2017,24(7):1195-1199.[10]邢鹏.米非司酮联合甲氨蝶呤对宫外孕患者血β-HCG转阴及临床症状的影响[J].临床研究,2018,26(11):28-29.[11]李幸丽.米非司酮与甲氨蝶呤联用对宫外孕的治疗效果分析[J].海峡药学,2018,30(10):138-139.[12]赵梅.米非司酮+甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的治愈率及不良反应发生率评价[J].临床医学研究与实践,2018,3(29):60-61.[13]吕琼琼,肖慧,王婷,等.米非司酮、甲氨蝶呤用于宫外孕保守治疗中的疗效及对患者β-HCG、CA125的影响[J].中国性科学,2018,27(7):70-73.[14]Ahmed MR,Sayed Ahmed WA,Mohamed TY.Day 1 change in maternal serum β-HCG levels as an early predictor of successful medical therapy in ectopic pregnancies[J].J Matern Fetal Neonatal Med,2020,33(14):2403-2407.[15]付昕.血β-hCG值检测对宫外孕患者治疗方案选择的指导意义[J].临床研究,2018,26(5):135-136.[16]宁小军.甲氨蝶呤高低剂量对异位妊娠患者血药浓度及临床疗效探讨[J].山西医药杂志,2019,48(19):2378-2379.[17]马瑶瑶,董跃,邓杰.米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的临床疗效分析[J].当代医学,2018,24(7):82-84.[18]Kovaleva A,Irishina N,Pereira A,et al.Methotrexate-treated ectopic pregnancy: beta human chorionic gonadotropin serum changes as a success predictor using a mathematical model validation[J].Eur J Obstet Gynecol Reprod Biol,2017(210):35-38.[19]段绍琳.甲氨蝶呤与米非司酮结合应用在不同血β-HCG浓度宫外孕治疗中的疗效观察[J].医学理论与实践,2019,32(8):1214-1216.[20]Conti V,Luciano G,Pecoraro G,et al.Multidosing Intramuscular Administration of Methotrexate in Interstitial Pregnancy With Very High Levels of β-hCG: A Case Report and Review of the Literature[J].Frontiers in Endocrinology,2018,9(1):363.

相似文献/References:

[1]郑 莉.经阴道彩色多普勒超声早期诊断宫外孕的临床价值分析[J].医学信息,2018,(09):159.[doi:10.3969/j.issn.1006-1959.2018.09.052]
 ZHENG Li.Clinical Value of Transvaginal Color Doppler Ultrasound in the Early Diagnosis of Ectopic Pregnancy[J].Medical Information,2018,(24):159.[doi:10.3969/j.issn.1006-1959.2018.09.052]
[2]唐 勇,周 乐.羟考酮用于宫外孕手术患者全麻诱导插管的临床研究[J].医学信息,2019,(15):136.[doi:10.3969/j.issn.1006-1959.2019.15.044]
 TANG Yong,ZHOU Le.Clinical Study of Oxycodone in General Anesthesia Induced Intubation in Patients Undergoing Ectopic Pregnancy[J].Medical Information,2019,(24):136.[doi:10.3969/j.issn.1006-1959.2019.15.044]
[3]韩怡波.儿童急淋大剂量甲氨蝶呤延迟解救的安全性研究[J].医学信息,2019,(19):143.[doi:10.3969/j.issn.1006-1959.2019.19.046]
 HAN Yi-bo.Safety Study on Delayed Rescue of High-Dose Methotrexate in Children[J].Medical Information,2019,(24):143.[doi:10.3969/j.issn.1006-1959.2019.19.046]
[4]丁宇康.化瘀通痹方联合甲氨蝶呤治疗难治性类风湿关节炎的效果[J].医学信息,2019,(24):171.[doi:10.3969/j.issn.1006-1959.2019.24.063]
 DING Yu-kang.Observation of Huayu Tongbi Recipe Combined with Methotrexate in the Treatment of Refractory Rheumatoid Arthritis[J].Medical Information,2019,(24):171.[doi:10.3969/j.issn.1006-1959.2019.24.063]
[5]周文旭,谭湘淑,佘 君,等.类风湿关节炎大鼠滑膜细胞凋亡基因调控的实验研究[J].医学信息,2020,(05):71.[doi:10.3969/j.issn.1006-1959.2020.05.021]
 ZHOU Wen-xu,TAN Xiang-shu,SHE Jun,et al.Experimental Study on Regulation of Apoptosis Genes in Synovial Cells of Rats with Rheumatoid Arthritis[J].Medical Information,2020,(24):71.[doi:10.3969/j.issn.1006-1959.2020.05.021]
[6]张 彬,齐红梅,王红燕,等.高强度聚焦超声联合清宫术治疗剖宫产瘢痕妊娠的疗效[J].医学信息,2020,(06):115.[doi:10.3969/j.issn.1006-1959.2020.06.035]
 ZHANG Bin,QI Hong-mei,WANG Hong-yan,et al.Efficacy of High-intensity Focused Ultrasound Combined with Uterine Hysterectomy in Cesarean Scar Pregnancy[J].Medical Information,2020,(24):115.[doi:10.3969/j.issn.1006-1959.2020.06.035]
[7]朱 冰.经阴道超声对未破裂型宫外孕的诊断价值[J].医学信息,2020,(18):173.[doi:10.3969/j.issn.1006-1959.2020.18.058]
 ZHU Bing.The Diagnostic Value of Transvaginal Ultrasound for Unruptured Ectopic Pregnancy[J].Medical Information,2020,(24):173.[doi:10.3969/j.issn.1006-1959.2020.18.058]
[8]段 然.B超引导下宫腔镜电切术联合甲氨蝶呤治疗子宫切口瘢痕妊娠的可行性分析[J].医学信息,2021,(03):134.[doi:10.3969/j.issn.1006-1959.2021.03.037]
 DUAN Ran.Feasibility Analysis of B-ultrasound Guided Hysteroscopic Resection Combined with Methotrexate in the Treatment of Uterine Incision Scar Pregnancy[J].Medical Information,2021,(24):134.[doi:10.3969/j.issn.1006-1959.2021.03.037]
[9]卓 勤,魏 璐.甲氨蝶呤联合防己黄芪汤治疗类风湿关节炎的效果及对患者生活质量的影响[J].医学信息,2021,(24):150.[doi:10.3969/j.issn.1006-1959.2021.24.039]
 ZHUO Qin,WEI Lu.Effect of Methotrexate Combined with Fangji Huangqi Decoction in the Treatment of Rheumatoid Arthritis and its Influence on the Quality of Life[J].Medical Information,2021,(24):150.[doi:10.3969/j.issn.1006-1959.2021.24.039]
[10]范叶柏,宫 雪,杨晓晨.米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的临床安全性和有效性比较[J].医学信息,2021,(13):170.[doi:10.3969/j.issn.1006-1959.2021.13.047]
 FAN Ye-bai,GONG Xue,YANG Xiao-chen.Comparison of the Clinical Safety and Effectiveness of Mifepristone Combined with Methotrexate and Methotrexate Alone in the Treatment of Ectopic Pregnancy[J].Medical Information,2021,(24):170.[doi:10.3969/j.issn.1006-1959.2021.13.047]

更新日期/Last Update: 1900-01-01