[1]卓 勤,魏 璐.甲氨蝶呤联合防己黄芪汤治疗类风湿关节炎的效果及对患者生活质量的影响[J].医学信息,2021,34(24):150-153.[doi:10.3969/j.issn.1006-1959.2021.24.039]
 ZHUO Qin,WEI Lu.Effect of Methotrexate Combined with Fangji Huangqi Decoction in the Treatment of Rheumatoid Arthritis and its Influence on the Quality of Life[J].Medical Information,2021,34(24):150-153.[doi:10.3969/j.issn.1006-1959.2021.24.039]
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甲氨蝶呤联合防己黄芪汤治疗类风湿关节炎的效果及对患者生活质量的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年24期
页码:
150-153
栏目:
中医中药
出版日期:
2021-12-15

文章信息/Info

Title:
Effect of Methotrexate Combined with Fangji Huangqi Decoction in the Treatment of Rheumatoid Arthritis and its Influence on the Quality of Life
文章编号:
1006-1959(2021)24-0150-04
作者:
卓 勤魏 璐
(1.湖北中医药大学第一临床学院,湖北 武汉 430061;2.湖北中医药大学附属医院风湿病科,湖北 武汉 430061)
Author(s):
ZHUO QinWEI Lu
(1.The First Clinical College of Hubei University of Chinese Medicine,Wuhan 430061,Hubei,China;2.Department of Rheumatology,Affiliated Hospital of Hubei University of Chinese Medicine,Wuhan 430061,Hubei,China)
关键词:
类风湿关节炎甲氨蝶呤防己黄芪汤晨僵
Keywords:
Rheumatoid arthritisMethotrexateFangji Huangqi decoctionMorning stiffness
分类号:
R684
DOI:
10.3969/j.issn.1006-1959.2021.24.039
文献标志码:
A
摘要:
目的 研究甲氨蝶呤联合防己黄芪汤治疗类风湿关节炎的效果及对患者生活质量的影响。方法 选取2020年6月-2021年6月湖北中医药大学附属医院收治的92例类风湿关节炎患者,依照随机数字表法分为对照组与观察组,各46例。对照组应用甲氨蝶呤治疗,观察组应用甲氨蝶呤联合防己黄芪汤治疗,比较两组症状及体征变化、实验室指标[类风湿因子(RF)、红细胞沉降率(ESR)、C-反应蛋白(CRP)]、28个关节疾病活动度(DAS28)、综合疗效、不良反应及生活质量[健康调查简表(SF-36)]。结果 两组晨僵时间缩短,压痛及肿胀关节数目减少,且观察组晨僵时间短于对照组,压痛及肿胀关节数目少于对照组,差异有统计学意义(P<0.05);两组RF、ESR、CRP水平均有下降,且观察组低于对照组(P<0.05);两组DAS28均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05);观察组SF-36评分高于对照组,差异有统计学意义(P<0.05)。结论 甲氨蝶呤联合防己黄芪汤治疗类风湿关节炎疗效确切,可改善患者症状及体征,降低疾病相关指标,减少药物不良反应,促进生活质量的提升。
Abstract:
Objective To study the effect of methotrexate combined with Fangji Huangqi decoction in the treatment of rheumatoid arthritis and its influence on the quality of life of patients.Methods A total of 92 patients with rheumatoid arthritis admitted to the Affiliated Hospital of Hubei University of Chinese Medicine from June 2020 to June 2021 were selected and divided into the control group and the observation group according to the random number table method, with 46 cases in each group. The control group was treated with methotrexate, and the observation group was treated with methotrexate combined with Fangji Huangqi decoction. The changes in symptoms and signs, laboratory indicators [rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)], activity of 28 joint diseases (DAS28), comprehensive efficacy, adverse reactions and quality of life [36-item short form health survey (SF-36)].Results The morning stiffness time of the two groups was shortened, and the number of tender and swollen joints was decreased, and the morning stiffness time of the observation group was shorter than that of the control group, and the number of tender and swollen joints was less than that of the control group, the difference was statistically significant (P<0.05); The levels of RF, ESR and CRP in the two groups were decreased, and those in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05).The DAS28 of the two groups were lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). The SF-36 score of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05).Conclusion The combination of methotrexate and Fangji Huangqi decoction has a definite effect in the treatment of rheumatoid arthritis, which can improve the symptoms and signs of patients, reduce disease-related indicators, reduce adverse drug reactions, and promote the improvement of quality of life.

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更新日期/Last Update: 1900-01-01