[1]刘钰婵,张 威,邱 俊,等.感兴趣区选取数量对脑胶质瘤IVIM参数测量的影响[J].医学信息,2022,35(01):84-88.[doi:10.3969/j.issn.1006-1959.2022.01.020]
　LIU Yu-chan,ZHANG Wei,QIU Jun,et al.The Influence of the Number of Selected ROIs on the Measurement of IVIM Parameters of Glioma[J].Medical Information,2022,35(01):84-88.[doi:10.3969/j.issn.1006-1959.2022.01.020]
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感兴趣区选取数量对脑胶质瘤IVIM参数测量的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年01期
页码:
84-88
栏目:
论著
出版日期:
2022-01-01

文章信息/Info

Title:
The Influence of the Number of Selected ROIs on the Measurement of IVIM Parameters of Glioma
文章编号:
1006-1959（2022）01-0084-05
作者:
刘钰婵; 张 威; 邱 俊; 等
（安徽医科大学附属省立医院南区影像中心，安徽 合肥 230036）
Author(s):
LIU Yu-chan; ZHANG Wei; QIU Jun; et al.
(The Southern District Imaging Center,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230036,Anhui,China）
关键词:
感兴趣区; 体素内不相干运动; 胶质瘤
Keywords:
Region of interest; Intravoxel incoherent motion; Gliomas
分类号:
R459.5
DOI:
10.3969/j.issn.1006-1959.2022.01.020
文献标志码:
A
摘要:
目的 探讨感兴趣区选取数量对脑胶质瘤IVIM参数测量的影响。方法 回顾性分析2019年5月-2020年8月我院收治的56例胶质瘤患者治疗前MRI平扫、增强和IVIM-DWI图像，通过后处理软件测量肿瘤实质区、瘤周水肿区及对侧正常白质的表观扩散系数（ADC）、真扩散系数（D）、伪扩散系数（D*）、灌注分数（f），采用小圆形ROI勾画法（30~45 mm2）对以上三种不同区域分别选取3个（3点法）、5个（5点法）、10个（10点法）感兴趣区，比较不同数量ROI所得参数值的差异。结果 三种ROI方法不同区域ADC、D*、D、f比较，差异无统计学意义（P＞0.05），但三种方法测得肿瘤实质区及瘤周水肿区的IVIM参数可重复性高（ICC＞0.8），测量对侧正常白质IVIM参数的可重复性较好（ICC＞0.6）；肿瘤实质区、瘤周水肿区、对侧正常白质的ADC、D*、D值比较，差异有统计学意义（P＜0.05），且肿瘤实质区、瘤周水肿区的ADC、D值高于对侧正常白质，D*值低于对侧；三区域间f值比较，差异无统计学意义（P＞0.05）。测量肿瘤实质区、瘤周水肿区、对侧正常白质的ADC、D值时，5点法、10点法（AUC=0.7）诊断效能优于3点法（AUC＜0.7）；测量D*、f时，三种ROI方法AUC均＜0.7。结论 选取不同数量感兴趣区获得的脑胶质瘤IVIM参数具有较高的可重复性，但在比较不同区域IVIM参数差异时，5点法及10点法测量ADC、D的性能优于3点法，三种方法均不适合测量D*及f。
Abstract:
Objective To explore the influence of the number of selected ROIs on the measurement of IVIM parameters of glioma.Methods The plain, enhanced and IVIM-DWI images of 56 patients with glioma before treatment in our hospital from May 2019 to August 2020 were retrospectively analyzed. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) of tumor parenchyma, peritumoral edema and contralateral normal white matter were measured by post-processing software. Three (3-point method), five (5-point method), and ten (10-point method) regions of interest were selected for the above three different regions by using the small circle ROI mapping method (30-45 mm2), The parameter values of different ROIs were compared.Results There was no significant difference in ADC, D*, D and f among the three ROI methods in different regions (P>0.05), however, the repeatability of IVIM parameters measured by the three ROI methods in tumor parenchyma and peritumoral edema was high (ICC>0.8), and the repeatability of IVIM parameters measured in contralateral normal white matter was good (ICC>0.6). The ADC, D* and D values of tumor parenchyma, peritumoral edema and contralateral normal white matter were compared, and the differences were statistically significant (P<0.05). When ADC and D values of tumor parenchyma, peritumoral edema and contralateral normal white matter were measured, the diagnostic efficacy of 5-point method and 10-point method (AUC=0.7) was better than that of 3-point method (AUC<0.7). When D* and f were measured, the AUC of three ROI methods were <0.7.Conclusion The IVIM parameters of glioma obtainedby selecting different numbers of regions of interest have high reproducibility. However, when comparing the differences of IVIM parameters in different regions, the performance of 5-point method and 10-point method in measuring ADC and D is better than that of 3-point method, and the three methods are not suitable for measuring D* and f.

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更新日期/Last Update: 1900-01-01