[1]刘翠莲,谢静仪,胡 秋,等.肌炎特异性抗体与特发性炎性肌病患者症状特征及短期预后的相关性分析[J].医学信息,2022,35(02):83-85.[doi:10.3969/j.issn.1006-1959.2022.02.020]
　LIU Cui-lian,XIE Jing-yi,HU Qiu,et al.Correlation Analysis of Myositis Specific Antibody with Symptom Characteristicsand Short-term Prognosis in Patients with Idiopathic Inflammatory Myopathy[J].Medical Information,2022,35(02):83-85.[doi:10.3969/j.issn.1006-1959.2022.02.020]
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肌炎特异性抗体与特发性炎性肌病患者症状特征及短期预后的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
83-85
栏目:
论著
出版日期:
2022-01-15

文章信息/Info

Title:
Correlation Analysis of Myositis Specific Antibody with Symptom Characteristicsand Short-term Prognosis in Patients with Idiopathic Inflammatory Myopathy
文章编号:
1006-1959（2022）02-0083-03
作者:
刘翠莲; 谢静仪; 胡 秋; 孙保东
深圳市人民医院风湿免疫科，广东 深圳 518020
Author(s):
LIU Cui-lian; XIE Jing-yi; HU Qiu; SUN Bao-dong
Department of Rheumatology and Immunology,Shenzhen People’s Hospital,Shenzhen 518020,Guangdong,China
关键词:
特发性炎性肌病; 肌炎特异性抗体; 短期预后; 间质性肺病
Keywords:
Idiopathic inflammatory myopathies; Myositis specific antibody; Short-term prognosis; Interstitial lung disease
分类号:
R685
DOI:
10.3969/j.issn.1006-1959.2022.02.020
文献标志码:
A
摘要:
目的 研究肌炎特异性抗体（MSAs）与特发性炎性肌病患者症状特征及短期预后的相关性。方法 收集2018年6月-2020年6月经我院确诊的48例特发性炎性肌病患者的临床资料进行回顾性分析，依据MSAs的检出结果分为MSAs阳性组（n=32）与MSAs阴性组（n=16），比较两组症状特征及短期预后情况，分析MSAs亚型与症状特征的相关性。结果 MSAs阳性组间质性肺病（ILD）及吞咽困难的发生率高于MSAs阴性组（P＜0.05）；两组V颈征、向阳疹、Gottron征、披肩征、技工手、雷诺现象、关节炎、肌痛、肌无力、皮下钙化发生率比较，差异无统计学意义（P＞0.05）；经单因素及Logistic回归分析显示，抗转录中介因子γ（TIF1-γ）抗体阳性、抗氨基酰tRNA合成酶（ARS）抗体阳性、抗小泛素样修饰物活化酶（SAE）抗体阳性是吞咽困难发生的独立危险因素（P＜0.05，OR＞1），而抗黑色素瘤分化相关基因5（MDA5）抗体阳性是吞咽困难的保护因素（P＜0.05，OR＜1）；抗MDA5阳性是ILD的独立危险因素（P＜0.05，OR＞1），抗Mi-2抗体阳性、抗TIF1-γ抗体阳性为ILD的保护因素（P＜0.05，OR＜1）；1年的随访观察中，MSAs阳性组与MSAs阴性组的预后生存情况比较，差异无统计学意义（P＞0.05）。结论 MSAs与特发性炎性肌病中ILD及吞咽困难的发生存在相关性，但MSAs对患者短期预后并无直接影响。
Abstract:
Objective To study the correlation between myositis-specific antibodies (MSAs) and the symptoms and short-term prognosis of patients with idiopathic inflammatory myopathy.Methods The clinical data of 48 patients with idiopathic inflammatory myopathy diagnosed in our hospital from June 2018 to June 2020 were retrospectively analyzed. According to the detection results of MSAs, they were divided into MSAs positive group (n=32) and MSAs negative group (n=16). The symptom characteristics and short-term prognosis of the two groups were compared, and the correlation between MSAs subtypes and symptom characteristics was analyzed.Results The incidence of interstitial lung disease (ILD) and dysphagia in MSAs positive group was higher than that in MSAs negative group (P<0.05); there was no significant difference in the incidence of V neck sign, Yang rash, Gottron sign, shawl sign, technician, Reynolds phenomenon, arthritis, muscle pain, muscle weakness and subcutaneous calcification between the two groups (P>0.05).Single factor and Logistic regression analysis showed that anti-transcription mediator factor γ (TIF1-γ) antibody positive, anti-aminoacyl tRNA synthetase (ARS) antibody positive and anti-small ubiquitin-like modifier activator (SAE) antibody positive were independent risk factors for dysphagia (P<0.05，OR>1), while anti-melanoma differentiation-related gene 5 (MDA5) antibody positive was a protective factor for dysphagia (P<0.05，OR<1); anti-MDA5 positive was an independent risk factor for ILD (P<0.05，OR>1), anti-Mi-2 antibody positive and anti-TIF1-γ antibody positive were protective factors for ILD (P<0.05，OR<1).During one-year follow-up, there was no significant difference in the prognosis and survival between MSAs positive group and MSAs negative group (P>0.05).Conclusion MSAs are associated with ILD and dysphagia in idiopathic inflammatory myopathy, but MSAs have no direct effect on the short-term prognosis of patients.

参考文献/References:

[1]Sag E,Demir S,Bilginer Y,et al.Clinical features， muscle biopsy scores， myositis specific antibody profiles and outcome in juvenile dermatomyositis[J].Semin Arthritis Rheum,2021,51(1): 95-100.[2]樊志丹,马慧慧,郭翼红,等.肌炎特异性抗体在幼年特发性炎症性肌病中的意义[J].中华实用儿科临床杂志,2020,35(24):1876-1880.[3]朱冯赟智,邢晓燕,汤晓菲,等.肌炎合并血栓栓塞患者的临床及免疫学特征[J].北京大学学报(医学版),2020,52(6):995-1000.[4]肖栋梅,王庭辉,赵宝景,等.肌炎特异性抗体亚型在多肌炎/皮肌炎患者临床特征及预后中的价值[J].浙江医学,2020,42(21):2327-2334,2377.[5]王雯雯,张培玉,王俊狄,等.多发性肌炎/皮肌炎患者肌炎特异性抗体与临床特征相关性分析[J].浙江医学,2020,42(16):1716-1720,1728.[6]Sontheimer RD.Dermatomyositis: an overview of recent progress with emphasis on dermatologic aspects[J].Dermatol Clin,2002,20(3):387-408.[7]王琰,李伟,刘升云.特发性炎性肌病自身抗体与血清心肌肌钙蛋白Ⅰ相关性研究[J].医药论坛杂志,2020,41(4):45-48.[8]Piette Y,De Sloovere M,Vandendriessche S,et al.Pitfalls in the detection of myositis specific antibodies by lineblot in clinically suspected idiopathic inflammatory myopathy[J].Clin Exp Rheumatol,2020,38(2):212-219. [9]杨亮,付俊,宋佳,等.抗核基质蛋白2抗体阳性炎性肌病临床及病理分析[J].国际神经病学神经外科学杂志,2019,46(6):596-600.[10]石景丽,李珊珊,杨阚波,等.肌炎特异性自身抗体对多发性肌炎/皮肌炎患者预后影响[J].中华风湿病学杂志,2018,22(1):9-15.[11]杜望磊,李治琴,杨西超,等.儿童皮肌炎与肌炎特异性抗体之间的相关性研究[J].河北医学,2019,25(4):671-676.[12]谢苗苗,演欣,李慧,等.多肌炎/皮肌炎相关间质性肺疾病患者肌炎特异性抗体检测的临床意义[J].中华结核和呼吸杂志,2018,41(8):616-621.[13]Pachman LM,Khojah AM.Advances in Juvenile Dermatomyositis: Myositis Specific Antibodies Aid in Understanding Disease Heterogeneity[J].J Pediatr,2018(195):16-27. [14]郑松塬,陈世贤,吴利生,等.特发性炎症性肌病的分类:基于临床表现和肌炎特异性抗体[J].南方医科大学学报,2020,40(7):1029-1035.[15]李珊珊,葛永鹏,杨阚波,等.皮肌炎患者427例肌炎特异性抗体谱及与临床特征相关性分析[J].中华风湿病学杂志,2017,21(9):585-594.[16]王涛,石景丽,张亚妹,等.抗Mi-2抗体不同亚型的临床异质性研究[J].中日友好医院学报,2017,31(1):7-10,17.[17]李梦圆,陈斌锋,周绵菁,等.抗MDA5阳性的特发性炎性肌病的临床特征[J].广东医学,2020,41(7):683-687.[18]张梦阳.特发性炎性肌病特异性自身抗体的临床相关性研究[D].青岛:青岛大学,2020.[19]刘柳,陈竹,陶金辉,等.特发性炎性肌病肌炎特异性抗体谱的临床意义[J].中华临床免疫和变态反应杂志,2020,14(2):135-142.[20]张铭明,张锐,杨小珂,等.特发性炎性肌病患者酶谱指标,炎症指标,自身抗体水平分析[J].检验医学与临床,2020,17(6):17-21.

更新日期/Last Update: 1900-01-01