[1]宋晨音.苯磺酸氨氯地平联合替米沙坦治疗高血压病的有效性和安全性研究[J].医学信息,2022,35(02):166-168.[doi:10.3969/j.issn.1006-1959.2022.02.043]
　SONG Chen-yin.Study on Efficacy and Safety of Amlodipine Besylate Combined with Telmisartanin the Treatment of Hypertension[J].Medical Information,2022,35(02):166-168.[doi:10.3969/j.issn.1006-1959.2022.02.043]
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苯磺酸氨氯地平联合替米沙坦治疗高血压病的有效性和安全性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
166-168
栏目:
药物与临床
出版日期:
2022-01-15

文章信息/Info

Title:
Study on Efficacy and Safety of Amlodipine Besylate Combined with Telmisartanin the Treatment of Hypertension
文章编号:
1006-1959（2022）02-0166-03
作者:
宋晨音
天津市南开区王顶堤医院内科，天津 300191
Author(s):
SONG Chen-yin
Department of Internal Medicine,Wangdingdi Hospital of Nankai District,Tianjin 300191,China
关键词:
苯磺酸氨氯地平; 替米沙坦; 高血压; 血尿酸
Keywords:
Amlodipine besylate; Telmisartan; Hypertension; Blood uric acid
分类号:
R544
DOI:
10.3969/j.issn.1006-1959.2022.02.043
文献标志码:
A
摘要:
目的 研究苯磺酸氨氯地平联合替米沙坦治疗高血压病有效性和安全性。方法 选取2020年4月-2021年4月在我院诊治的300例高血压病患者为研究对象，采用随机数字表法分为对照组和观察组，各150例。对照组采用苯磺酸氨氯地平治疗，观察组在对照组基础上联合替米沙坦治疗，比较两组临床治疗总有效率、血压水平、血尿酸水平以及临床不良反应发生率。结果 观察组治疗总有效率为94.67%，高于对照组的83.33%（P＜0.05）；两组收缩压、舒张压均低于治疗前，且观察组低于对照组（P＜0.05）；两组血尿酸水平均低于治疗前，且观察组低于对照组（P＜0.05）；观察组临床不良反应发生率为5.33%，低于对照组的12.00%（P＜0.05）。结论 苯磺酸氨氯地平联合替米沙坦治疗高血压病效果确切，可提高临床治疗总有效率，降低血压水平，改善血尿酸水平，且可降低临床不良反应，具有良好的应用有效性和安全性，具有重要的临床应用价值。
Abstract:
Objective To study the efficacy and safety of amlodipine besylate combined with telmisartan in the treatment of hypertension.Methods A total of 300 patients with hypertension who were treated in our hospital from April 2020 to April 2021 were selected as the research objects. They were randomly divided into control group and observation group, with 150 cases in each group. The control group was treated with amlodipine besylate, and the observation group was treated with telmisartan on the basis of the control group. The total effective rate, blood pressure level, blood uric acid level and incidence of clinical adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.67%, which was higher than 83.33% of the control group (P<0.05). After treatment, systolic blood pressure and diastolic blood pressure in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). The levels of serum uric acid in the two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05). The incidence of clinical adverse reactions in the observation group was 5.33%, which was lower than 12.00% in the control group (P<0.05).Conclusion Amlodipine besylate combined with telmisartan is effective in the treatment of hypertension, which can improve the total effective rate of clinical treatment, reduce blood pressure level, improve blood uric acid level, and reduce clinical adverse reactions. It has good application efficacy and safety, and has important clinical application value.

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更新日期/Last Update: 1900-01-01