[1]周小燕,雷 蓉,杨 丹,等.健康体检人群25（OH）D水平与甲状腺TI-RADS分类的相关性分析[J].医学信息,2022,35(03):152-155.[doi:10.3969/j.issn.1006-1959.2022.03.040]
　ZHOU Xiao-yan,LEI Rong,YANG Dan,et al.Correlation Analysis Between 25(OH)D Level and TI-RADS Classificationof Thyroid in Healthy Subjects[J].Medical Information,2022,35(03):152-155.[doi:10.3969/j.issn.1006-1959.2022.03.040]
点击复制

健康体检人群25（OH）D水平与甲状腺TI-RADS分类的相关性分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年03期
页码:
152-155
栏目:
调查分析
出版日期:
2022-02-01

文章信息/Info

Title:
Correlation Analysis Between 25(OH)D Level and TI-RADS Classificationof Thyroid in Healthy Subjects
文章编号:
1006-1959（2022）03-0152-04
作者:
周小燕; 雷 蓉; 杨 丹; 江毅敏; 王 冠; 柳 弥
川北医学院附属医院健康管理中心，四川 南充 637000
Author(s):
ZHOU Xiao-yan; LEI Rong; YANG Dan; JIANG Yi-min; WANG Guan; LIU Mi
Health Management Center,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China
关键词:
25（OH）D; TI-RADS分类; 甲状腺结节
Keywords:
25(OH)D; TI-RADS classification; Thyroid nodules
分类号:
R581
DOI:
10.3969/j.issn.1006-1959.2022.03.040
文献标志码:
A
摘要:
目的 探讨健康体检人群25-羟维生素D[25（OH）D]水平与TI-RADS分类的相关性。方法 选取2019年8月-2021年1月川北医学院附属医院10 023名接受甲状腺超声检查者作为研究对象，根据TI-RADS分类标准将无甲状腺结节设为对照组，TI-RADS 3类及以下者设为良性组，TI-RADS 4类及以上者设为低度恶性组。比较三组临床资料，分析25（OH）D水平与甲状腺结节的关系。结果 10 023名接受甲状腺超声检查者中无甲状腺结节6228名，TI-RADS3类及以下者3222名，TI-RADS 4类及以上者573名。三组年龄、收缩压（SBP）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、游离三碘甲状腺原氨酸（FT3）、25（OH）D比较，差异有统计学意义（P＜0.05）；三组体质指数（BMI）、舒张压（DBP）、空腹血糖（FPG）、甘油三脂（TG）、（LDL-C）、游离甲状腺素（FT4）、促甲状腺激素（TSH）、甲状腺球蛋白抗体（Tg-Ab）、甲状腺过氧化物酶抗体（TPO-Ab）比较，差异无统计学意义（P＞0.05）；Pearson相关性分析显示，25（OH）D与FT3呈正相关（r=0.129，P＜0.05），与TSH、Tg-Ab、TPO-Ab呈负相关（r=-0.076、-0.091、-0.070，P＜0.05）；多因素Logistic回归分析显示，年龄、SBP是甲状腺结节发生的独立危险因素，而25（OH）D是甲状腺结节发生的保护因素（P＜0.05）；此外，25（OH）D是低度恶性甲状腺结节发生的保护因素，TC是低度恶性甲状腺结节发生的危险因素（P＜0.05）。结论 血清25（OH）D水平随着TI-RADS严重程度的增加呈下降趋势，高水平的血清25（OH）D水平对甲状腺结节的发生、发展具有一定的保护作用。
Abstract:
Objective To investigate the correlation between 25-hydroxyvitamin D [25(OH)D] level and TI-RADS classification in healthy people.Methods A total of 10 023 patients who underwent thyroid ultrasound examination in the Affiliated Hospital of North Sichuan Medical College from August 2019 to January 2021 were selected as the subjects. According to TI-RADS classification criteria, no thyroid nodules were set as control group, TI-RADS 3 and below were set as benign group, TI-RADS 4 and above were set as low-grade malignant group. The clinical data of the three groups were compared to analyze the relationship between 25(OH)D level and thyroid nodules.Results Among the 10 023 receiving thyroid ultrasound examination, 6228 had no thyroid nodules, 3222 had TI-RADS3 and below, and 573 had TI-RADS4 and above. There were significant differences in age, systolic blood pressure (SBP), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), free triiodothyronine (FT3) and 25(OH)D among the three groups (P<0.05). There was no significant difference in body mass index (BMI), diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglyceride (TG), (LDL-C), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroglobulin antibody (Tg-Ab, and thyroid peroxidase antibody (TPO-Ab) among the three groups (P>0.05).Pearson correlation analysis showed that 25(OH)D was positively correlated with FT3 (r=0.129, P<0.05), and negatively correlated with TSH, Tg-Ab and TPO-Ab (r=-0.076, -0.091, -0.070, P<0.05). Multivariate Logistic regression analysis showed that age and SBP were independent risk factors for thyroid nodules, and 25(OH)D was a protective factor for thyroid nodules (P<0.05). In addition, 25(OH)D was a protective factor for low-grade malignant thyroid nodules, and TC was a risk factor for low-grade malignant thyroid nodules (P<0.05).Conclusion The level of serum 25(OH)D decreases with the increase of the severity of ultrasonic TI-RADS classification. High level of serum 25(OH)D has a certain protective effect on the occurrence and development of thyroid nodules.

参考文献/References:

[1]赖晓英,欧阳平,朱宏,等.甲状腺结节检出情况及影响因素:10年309 576例体检人群分析[J].南方医科大学学报,2020,40(2):268-273. [2]Espinosa De Ycaza AE,Lowe KM,Dean DS,et al.Risk of Malignancy in Thyroid Nodules with Non-Diagnostic Fine-Needle Aspiration: A Retrospective Cohort Study[J].Thyroid,2016,26(11):1598-1604. [3]Siegel RL,Miller KD,Jemal A.Cancer statistic,2018[J].CA Cancer J Clin,2018,68(1):7-30.[4]Bouillon R,Marcocci C,Carmeliet C,et al.Skeletal and Extraskeletal Actions of Vitamin D:Current Evidence and Outstanding Questions[J].Endocr Rev,2019,40(4):1109-1151. [5]Horvath E,Majlis S,Rossi R,et al.An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management[J].J Clin Endocrinol Metab,2009,94(5):1748-1751. [6]Mondul AM,Weinstein SJ,Layne TM,et al.Vitamin D and cancer risk and mortality:state of the science, gaps,and challenges[J].Epidemiol Rev,2017,39(1):28-48.[7]Jeon SM,Shin EA.Exploring vitamin D metabolism and function in cancer[J].Exp Mol Med,2018,50(4):20.[8]Bartonkova I,Kallay E,Dvorak Z.Effects of human an interleukins in the transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24 designed to assess the transcriptional activity of vitamin D receptor[J].PLoS One,2018,13(2):e0193655. [9]Hu MJ,Zhang Q,Liang L,et al.Association between vitamin D deficiency and risk of thyroid cancer:a case-control study and a mata-analysis[J].J Endocrinol Invest,2018,41(10):1199-1210.[10]Du X,Liu Y,Zhao C,et al.Changes of serum 25(OH)D3 and IGF-1levels in patients with thyroid nodules[J].BMC Endocrine Disorders,2019,19(1):48.[11]Chen WQ,Zheng RS,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.[12]中国抗癌协会甲状腺癌专业委员会(CATO).甲状腺癌血清标志物临床应用专家共识(2017版)[J].中国肿瘤临床,2018,45(1):7-13.[13]梅艳,王乔,赵力威,等.TSH抑制疗法对分化型甲状腺癌术后患者免疫功能及骨代谢的影响[J].重庆医学,2021,50(8):1381-1384. [14]方高洁,刘秀萍,胡恒贵,等.血清Tg-Ab、TPO-Ab、Tg水平与甲状腺结节恶性病变的相关性及临床意义[J].解放军预防医学杂志,2019,37(6):142-143.[15]朱海清,张金苹,帅瑛,等.抗甲状腺球蛋白抗体与>2.0 cm甲状腺结节恶性风险的相关性研究[J].中华全科医师杂志,2021,20(2):210-215. [16]Krysiak R,Szkróbka W,Okopień B.The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto’s Thyroiditis and Normal Vitamin D Status[J].Exp Clin Endocrinol Diabetes,2017,125(4):229-233. [17]Vahabi Anaraki P,Aminorroaya A,Amini M,et al.Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto’s thyroiditis: A double-blind randomized placebo-controlled clinical trial[J].J Res Med Sci,2017(22):103. [18]夏伟,张春艳,李蓬秋,等.妊娠期桥本甲状腺炎患者25维生素D水平变化及其影响因素分析[J].中国全科医学,2018,21(36):4476-4479.[19]邹冰,王新,孙丽.健康体检人群甲状腺结节患病率及其与代谢性疾病的关系研究[J].中国全科医学,2020,23(19):2423-2428.[20]王岚峰,王旭红.北京市通州区老年人甲状腺结节患病情况及相关因素分析[J].中华老年医学杂志,2020,39(9):1077-1081.

更新日期/Last Update: 1900-01-01