[1]曾 悦,罗秀丽,李成银,等.中药治疗胃癌患者癌因性疲乏疗效的Meta分析[J].医学信息,2022,35(05):63-68,79.[doi:10.3969/j.issn.1006-1959.2022.05.016]
　ZENG Yue,LUO Xiu-li,LI Cheng-yin,et al.Meta-analysis of the Efficacy of Traditional Chinese Medicine in the Treatment of Cancer-related Fatigue in Patients with Gastric Cancer[J].Medical Information,2022,35(05):63-68,79.[doi:10.3969/j.issn.1006-1959.2022.05.016]
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中药治疗胃癌患者癌因性疲乏疗效的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
63-68,79
栏目:
论著
出版日期:
2022-03-01

文章信息/Info

Title:
Meta-analysis of the Efficacy of Traditional Chinese Medicine in the Treatment of Cancer-related Fatigue in Patients with Gastric Cancer
文章编号:
1006-1959（2022）05-0063-07
作者:
曾 悦; 罗秀丽; 李成银; 等
（1.湖北中医药大学第一临床学院，湖北 武汉 430061；2.湖北省中医院肿瘤科，湖北 武汉 430061）
Author(s):
ZENG Yue; LUO Xiu-li; LI Cheng-yin; et al.
(1.The First Medical College,Hubei University of Chinese Medicine,Wuhan 430061,Hubei,China;2.Department of Oncology,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,Hubei,China)
关键词:
中药; 胃癌; 癌因性疲乏; RPFS评分; KPS评分; QLQ-C30评分; 免疫指标
Keywords:
Chinese medicine; Gastric cancer; Cancer-related fatigue; RPFS score; KPS score; QLQ-C30 score; Immune indexes
分类号:
R256.3；R735.2
DOI:
10.3969/j.issn.1006-1959.2022.05.016
文献标志码:
A
摘要:
目的 采用Meta分析方法评价中药治疗胃癌患者癌因性疲乏的临床疗效。方法 通过计算机检索中国知网 （CNKI）、万方数据库、维普网、中国生物医学文献服务系统（CBM）、Web of Science、PubMed、EMbase、Cochrane Library8个数据库，收集各数据库建库至2021年5月所有关于中药治疗胃癌患者癌因性疲乏的随机对照试验（RCT）研究，由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后，采用RevMan 5.4.1软件进行Meta分析。结果 最终纳入12篇RCT研究，共有977例胃癌患者。Meta分析结果显示，与对照组比较，联合使用中药能降低胃癌患者的PFS评分[MD=-0.90，95%CI（-1.12，-0.69），P＜0.00001]、RPFS评分[MD=-1.63，95%CI（-2.34，-0.92），P＜0.00001]，提高胃癌患者的KPS评分[MD=4.12，95%CI（1.98，6.27），P=0.0002]、QLQ-C30评分[MD=9.27，95%CI（6.74，11.79），P＜0.00001]，以及患者血清中CD3+[SMD=1.17，95%CI（0.37，1.98），P=0.004]、CD4+[SMD=0.75，95%CI（0.13，1.37），P=0.02]和CD4+/CD8+水平[SMD=0.83，95%CI（0.54，1.13），P＜0.00001]，提高中医证候评分 [SMD=-2.65，95%CI（-3.26，-2.03），P＜0.00001]；两组血清中CD8+水平比较，差异无统计学意义[SMD=-0.14，95%CI（-0.35，0.06），P=0.17]。结论 中药对胃癌患者癌因性疲乏有一定的改善作用，特别是健脾益气补血类中药，但需要开展更多大样本、设计严谨的高质量临床研究，以获得更可靠的研究数据，使其更好的指导临床。
Abstract:
Objective To evaluate the clinical efficacy of Chinese medicine in the treatment of cancer-related fatigue in patients with gastric cancer by Meta-analysis.Methods Eight databases including CNKI, Wanfang, VIP, CBM, Web of Science, PubMed, EMbase and Cochrane Library were searched by computer to collect all randomized controlled trials (RCTs) of traditional Chinese medicine in the treatment of cancer-related fatigue in patients with gastric cancer from the establishment of each database to May 2021. Two researchers independently screened literature, extracted data and evaluated the risk of bias of included studies. Meta-analysis was performed using RevMan 5.4.1 software.Results A total of 12 RCTs involving 977 patients with gastric cancer were included. Meta-analysis showed that compared with the control group, the combination of traditional Chinese medicine could reduce the PFS score [MD=-0.90, 95%CI(-1.12, -0.69), P<0.00001] and RPFS score [MD=-1.63, 95%CI(-2.34, -0.92), P<0.00001], increase KPS score [MD=4.12, 95%CI(1.98,6.27), P=0.0002], QLQ-C30 score [MD=9.27, 95%CI(6.74,11.79), P<0.00001], the serum levels of CD3+ [SMD=1.17, 95%CI(0.37,1.98), P=0.004], CD4+ [SMD=0.75, 95%CI(0.13,1.37), P=0.02], CD4+/CD8+ [SMD=0.83, 95%CI(0.54,1.13), P<0.00001] and TCM syndrome score [SMD=-2.65, 95%CI(-3.26, -2.03), P<0.00001] in patients with gastric cancer; there was no significant difference in serum CD8+ level between the two groups [SMD=-0.14, 95%CI(-0.35, 0.06), P=0.17].Conclusion Traditional Chinese medicine has a certain improvement effect on cancer-related fatigue in patients with gastric cancer, especially the traditional Chinese medicine of invigorating spleen, supplementing qi and supplementing blood. However, more large samples and rigorously designed high-quality clinical studies are needed to obtain more reliable research data and better guide clinical practice.

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更新日期/Last Update: 1900-01-01