[1]朱宝贤.阿莫西林联合强的松对非哺乳期乳腺炎患者免疫调节及炎性因子水平的影响[J].医学信息,2022,35(07):171-173.[doi:10.3969/j.issn.1006-1959.2022.07.045]
　ZHU Bao-xian.Effects of Amoxicillin Combined with Prednisone on Immune Regulation and Inflammatory Factors in Patients with Non-lactating Mastitis[J].Medical Information,2022,35(07):171-173.[doi:10.3969/j.issn.1006-1959.2022.07.045]
点击复制

阿莫西林联合强的松对非哺乳期乳腺炎患者免疫调节及炎性因子水平的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年07期
页码:
171-173
栏目:
药物与临床
出版日期:
2022-04-01

文章信息/Info

Title:
Effects of Amoxicillin Combined with Prednisone on Immune Regulation and Inflammatory Factors in Patients with Non-lactating Mastitis
文章编号:
1006-1959（2022）07-0171-03
作者:
朱宝贤
（天津港口医院药剂科，天津 300456）
Author(s):
ZHU Bao-xian
(Department of Pharmacy,Tianjin Port Hospital,Tianjin 300456,China)
关键词:
非哺乳期乳腺炎; 阿莫西林; 强的松; 免疫调节; 炎性因子
Keywords:
Non-lactating mastitis; Amoxicillin; Prednisone; Immune regulation; Inflammatory factors
分类号:
R655.8
DOI:
10.3969/j.issn.1006-1959.2022.07.045
文献标志码:
A
摘要:
目的 探究阿莫西林联合强的松对非哺乳期乳腺炎患者免疫调节及炎性因子水平的影响。方法 选取2020年5月-2021年5月我院收治的86例非哺乳期乳腺炎患者，依照随机数字表法分为对照组与观察组，各43例。对照组给予阿莫西林治疗，观察组给予阿莫西林联合强的松治疗，比较两组临床疗效、免疫指标（CD4+、CD8+、CD4+/CD8+）、炎性因子水平[白介素-6（IL-6）、C-反应蛋白（CRP）]、不良反应发生率及复发率。结果 观察组治疗有效率为86.05%，高于对照组的72.09%（P＜0.05）；观察组CD4+、CD4+/CD8+高于对照组，CD8+低于对照组（P＜0.05）；观察组IL-6、CRP水平低于对照组（P＜0.05）；观察组与对照组不良反应发生率比较，差异无统计学意义（P＞0.05）；随访3个月，观察组复发率为2.33%，低于对照组的13.95%（P＜0.05）。结论 阿莫西林联合强的松治疗非哺乳期乳腺炎疗效确切，可改善患者免疫功能，下调炎性表达，降低复发概率，且不增加药物不良反应。
Abstract:
Objective To explore the effects of amoxicillin combined with prednisone on immune regulation and inflammatory factor levels in patients with non-lactating mastitis.Methods A total of 86 non-lactating mastitis patients who were admitted from May 2020 to May 2021 were selected and divided into a control group and an observation group according to the random number table method, with 43 cases in each group. The control group was treated with amoxicillin, and the observation group was treated with amoxicillin combined with prednisone. The clinical efficacy, immune indicators (CD4+, CD8+, CD4+/CD8+), inflammatory factor levels [interleukin-6 (IL-6) and C-reactive protein (CRP)], adverse reactions and recurrence rates.Results The effective rate of the observation group was 86.05%, which was higher than 72.09% of the control group (P<0.05). CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, and CD8+ was lower than that in the control group (P<0.05). The levels of IL-6 and CRP in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). After 3 months of follow-up, the recurrence rate of the observation group was 2.33%, which was lower than 13.95% of the control group (P<0.05).Conclusion Amoxicillin combined with prednisone is effective in the treatment of non-lactating mastitis, which can improve the immune function of patients, reduce the inflammatory expression, reduce the recurrence probability, and do not increase the adverse drug reactions.

参考文献/References:

[1]严敏文,孙斌,汪伟.非哺乳期乳腺炎的危险因素病例对照研究及治疗措施[J].中国妇幼保健,2020,35(17):3197-3199.[2]刁岩,单昌友,赵阳,等.非哺乳期乳腺炎的临床治疗探讨[J].现代生物医学进展,2018,18(24):4695-4698,4668.[3]Russell SP,Neary C,Abd Elwahab S,et al.Breast infections - Microbiology and treatment in an era of antibiotic resistance[J].Surgeon,2020,18(1):1-7.[4]杨长安,王卿炜,杨波,等.不同方案治疗非哺乳期乳腺炎的疗效分析[J].中国现代医学杂志,2019,29(6):116-119.[5]Francoz D,Wellemans V,Dupré JP,et al.Invited review: A systematic review and qualitative analysis of treatments other than conventional antimicrobials for clinical mastitis in dairy cows[J].J Dairy Sci,2017,100(10):7751-7770.[6]梅海涛,武煦峰.消痈散结汤加减联合强的松治疗非哺乳期乳腺炎肿块期的疗效及预后观察[J].四川中医,2019,37(2):166-170.[7]周飞,刘璐,余之刚.非哺乳期乳腺炎诊治专家共识[J].中国实用外科杂志,2016,36(7):755-758.[8]张亚男,吕建鑫,胡浩霖,等.地塞米松联合庆大霉素在非哺乳期乳腺炎治疗中的临床应用[J].东南大学学报(医学版),2018,37(5):921-924.[9]李斌,杨学伟.非哺乳期乳腺炎的临床特点分析[J].中国全科医学,2017,20(36):4576-4580.[10]王伟.活血解毒丸联合阿莫西林分散片对急性乳腺炎的疗效及对淋巴细胞、炎症因子水平的影响[J].药物评价研究,2018,41(6):1082-1085.[11]李爱辉,李洪,王力斌,等.非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及意义[J].实用临床医学,2018,19(2):38-39,52.[12]梁小燕,刘忠民,黄海球,等.非哺乳期乳腺炎与人体固有免疫系统的关系及其临床意义[J].中国现代普通外科进展,2020,23(5):352-356.[13]李幸运.消痈散结汤加减联合强的松治疗非哺乳期乳腺炎(NPM)肿块期的临床效果[J].内蒙古中医药,2021,40(3):8-10.[14]许锐,郭倩倩,杨乐平,等.非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及其临床意义[J].南方医科大学学报,2016,36(8):1157-1159,1168.[15]马贞秀,张宝亮,赵成鹏,等.阿莫西林辅助强的松治疗非哺乳期乳腺炎对患者炎性因子水平及免疫功能水平的影响[J].河北医药,2019,41(19):2934-2936,2940.[16]刘璐,周飞,于理想,等.非哺乳期乳腺炎临床特征及危险因素分析[J].中国实用外科杂志,2016,36(7):774-777.[17]陈立平.浅析西药阿莫西林的药理作用机制以及临床应用[J].中国卫生标准管理,2016,7(18):83-84.[18]杨兴平.阿奇霉素联合左氧氟沙星对非哺乳期乳腺炎患者外周血淋巴细胞水平的影响[J].中国药物经济学,2018,13(7):74-76.[19]董明春,叶光荣,张伟,等.抗生素联合强的松治疗急性脓肿型非哺乳期乳腺炎的疗效观察及对外周血CD4+/CD8+比值的影响[J].河北医学,2016,22(1):95-99.

相似文献/References:

[1]张 勇.小切口手术联合可调节负压治疗非哺乳期乳腺炎的临床疗效[J].医学信息,2018,31(05):118.[doi:10.3969/j.issn.1006-1959.2018.05.041]
　ZHANG Yong.Clinical Effect of Small Incision Operation Combined with Adjustable Negative Pressure in the Treatment of Non-lactation Mastitis[J].Medical Information,2018,31(07):118.[doi:10.3969/j.issn.1006-1959.2018.05.041]
[2]罗宜辉,刘代华.益生菌联合四联方案根除幽门螺杆菌的临床研究[J].医学信息,2018,31(11):25.[doi:10.3969/j.issn.1006-1959.2018.11.008]
　LUO Yi-hui,LIU Dai-hua.Clinical Study on the Eradication of Helicobacter Pylori by Probiotics Combined with Quadruple Regimen[J].Medical Information,2018,31(07):25.[doi:10.3969/j.issn.1006-1959.2018.11.008]
[3]吕彤观.三联疗法治疗牙周病的临床效果观察[J].医学信息,2018,31(18):129.[doi:10.3969/j.issn.1006-1959.2018.18.041]
　LV Tong-guan.Clinical Observation of Triple Therapy for Periodontosis[J].Medical Information,2018,31(07):129.[doi:10.3969/j.issn.1006-1959.2018.18.041]
[4]谭利宽,杨 越.中西治疗非哺乳期乳腺炎的研究[J].医学信息,2018,31(20):38.[doi:10.3969/j.issn.1006-1959.2018.20.012]
　TAN Li-kuan,YANG Yue.Study on the Treatment of Non-lactating Mastitis by Chinese and Western Medicine[J].Medical Information,2018,31(07):38.[doi:10.3969/j.issn.1006-1959.2018.20.012]
[5]解 龙,练孝春,韩 涛,等.非哺乳期乳腺炎临床特征分析[J].医学信息,2019,32(06):128.[doi:10.3969/j.issn.1006-1959.2019.06.040]
　XIE Long,LIAN Xiao-chun,HAN Tao,et al.Analysis of Clinical Features of Non-lactating Mastitis[J].Medical Information,2019,32(07):128.[doi:10.3969/j.issn.1006-1959.2019.06.040]

更新日期/Last Update: 1900-01-01