[1]陈艳男,徐 劲.脑梗死患者血清SAA、hs-CRP与颅内动脉粥样硬化狭窄程度的相关性[J].医学信息,2022,35(09):120-123.[doi:10.3969/j.issn.1006-1959.2022.09.030]
　CHEN Yan-nan,XU Jin.Correlation Between Serum SAA, hs-CRP and Intracranial Atherosclerotic Stenosis in Patients with Cerebral Infarction[J].Medical Information,2022,35(09):120-123.[doi:10.3969/j.issn.1006-1959.2022.09.030]
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脑梗死患者血清SAA、hs-CRP与颅内动脉粥样硬化狭窄程度的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年09期
页码:
120-123
栏目:
论著
出版日期:
2022-05-01

文章信息/Info

Title:
Correlation Between Serum SAA, hs-CRP and Intracranial Atherosclerotic Stenosis in Patients with Cerebral Infarction
文章编号:
1006-1959（2022）09-0120-04
作者:
陈艳男; 徐 劲
（安徽医科大学附属巢湖医院神经内科，安徽 合肥 230001）
Author(s):
CHEN Yan-nan; XU Jin
(Department of Neurology,Chaohu Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui,China)
关键词:
脑梗死; 淀粉样蛋白A; 超敏C反应蛋白; 颅内动脉粥样硬化性狭窄
Keywords:
Cerebral infarction; Amyloid A; High sensitivity C-reactive protein; Intracranial artery atherosclerotic stenosis
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.09.030
文献标志码:
A
摘要:
目的 探讨脑梗死患者血清淀粉样蛋白A水平（SAA）、超敏C反应蛋白（hs-CRP）与颅内动脉粥样硬化狭窄程度的相关性。方法 选取2020年11月-2021年7月安徽医科大学附属巢湖医院收治的脑梗死患者137例作为试验组，另选取同期就诊于我院头晕合并颅内动脉粥样硬化患者53例作为对照组，比较试验组与对照组及试验组不同颅内动脉粥样硬化狭窄程度患者血清SAA、hs-CRP水平，分析脑梗死患者颅内动脉粥样硬化狭窄程度的影响因素，另采用ROC曲线分析血清SAA、hs-CRP诊断脑梗死颅内动脉粥样硬化狭窄程度的诊断效能。结果 试验组血清SAA、hs-CRP水平高于对照组，差异有统计学意义（P＜0.05）；不同颅内动脉粥样硬化狭窄程度患者SAA、hs-CRP水平比较，差异有统计学意义（P＜0.05），且随着颅内动脉粥样硬化狭窄程度增加，血清SAA、hs-CRP水平随之升高；有序Logistic回归分析显示，血清SAA、hs-CRP是脑梗死患者颅内动脉粥样硬化的危险因素（P＜0.05）；ROC曲线分析显示，血清SAA、hs-CRP预测颅内动脉粥样硬化的截断点分别为2.25 ml/L，1.21 mg/L，AUC均＞0.7。结论 血清 SAA、hs-CRP均参与脑梗死发病，是影响脑梗死患者颅内动脉粥样硬化发生的危险因素，可能成为预测颅内动脉粥样硬化的生物标志物，对早期干预具有重要临床意义。
Abstract:
Objective To investigate the correlation between serum amyloid A (SAA), high-sensitivity C-reactive protein (hs-CRP) and intracranial atherosclerotic stenosis in patients with cerebral infarction.Methods A total of 137 patients with cerebral infarction admitted to Chaohu Hospital Affiliated to Anhui Medical University from November 2020 to July 2021 were selected as the experimental group, and 53 patients with dizziness and intracranial atherosclerosis admitted to our hospital during the same period were selected as the control group. The levels of serum SAA and hs-CRP were compared between the experimental group and the control group and patients with different degrees of intracranial atherosclerosis stenosis in the experimental group. The influencing factors of intracranial atherosclerosis stenosis in patients with cerebral infarction were analyzed. ROC curve was used to analyze the diagnostic efficiency of serum SAA and hs-CRP in the diagnosis of intracranial atherosclerosis stenosis in cerebral infarction.Results The levels of serum SAA and hs-CRP in the experimental group were higher than those in the control group, and the difference was statistically significant (P<0.05). There were significant differences in the levels of SAA and hs-CRP among patients with different degrees of intracranial atherosclerosis stenosis (P<0.05), and with the increase of intracranial atherosclerosis stenosis, serum SAA and hs-CRP levels increased. Logistic regression analysis showed that serum SAA and hs-CRP were risk factors for intracranial atherosclerosis in patients with cerebral infarction (P<0.05). ROC curve analysis showed that the cut-off points of serum SAA and hs-CRP for predicting intracranial atherosclerosis were 2.25 ml/L, 1.21 mg/L, AUC>0.7.Conclusion Serum SAA and hs-CRP are involved in the pathogenesis of cerebral infarction, which are risk factors for intracranial atherosclerosis in patients with cerebral infarction. They may become biomarkers for predicting intracranial atherosclerosis, and have important clinical significance for early intervention.

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更新日期/Last Update: 1900-01-01