[1]桂慧慧,刘 霞.基于多数据库分析MYH10在肾透明细胞癌中的表达与意义[J].医学信息,2022,35(10):20-25.[doi:10.3969/j.issn.1006-1959.2022.10.004]
 GUI Hui-hui,LIU Xia.Expression and Significance of MYH10 in Renal Clear Cell Carcinoma Based on Multi-database Analysis[J].Medical Information,2022,35(10):20-25.[doi:10.3969/j.issn.1006-1959.2022.10.004]
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基于多数据库分析MYH10在肾透明细胞癌中的表达与意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
20-25
栏目:
生物信息学
出版日期:
2022-05-15

文章信息/Info

Title:
Expression and Significance of MYH10 in Renal Clear Cell Carcinoma Based on Multi-database Analysis
文章编号:
1006-1959(2022)10-0020-06
作者:
桂慧慧刘 霞
(深圳市第二人民医院病理科,广东 深圳 518000)
Author(s):
GUI Hui-huiLIU Xia
(Department of Pathology,Shenzhen Second People’s Hospital,Shenzhen 518000,Guangdong,China)
关键词:
肾透明细胞癌MYH10差异基因炎症反应免疫细胞浸润
Keywords:
Renal clear cell carcinomaMYH10Differential genesInflammatory responseImmune cell infiltration
分类号:
R737.11
DOI:
10.3969/j.issn.1006-1959.2022.10.004
文献标志码:
A
摘要:
目的 分析MYH10基因在肾透明细胞癌中的表达水平及意义。方法 应用UALCAN数据库分析MYH10基因在肾透明细胞癌组织与正常对照组织中的差异性表达、肿瘤分级、启动子甲基化和预后,应用 GEPIA 数据库检索MYH10基因的表达及肿瘤分级,应用GEPIA数据库分析MYH10基因表达对肾透明细胞癌患者生存时间的影响,应用Oncomine数据库检索肾透明细胞癌中与MYH10有共表达的基因,应用GEPIA分析MYH10与共表达基因的相关性,并通过 STRING数据库对MYH10的蛋白质相互作用网络进行分析。结果 肾透明细胞癌组织中MYH10表达水平低于正常组织(P<0.05);MYH10过表达与肿瘤分级相关,并且随分级增高MYH10表达降低(P<0.05);低表达的MYH10基因与患者低生存率有关(P<0.05);MYH10与RAB3A的共表达显著相关,MYH10可能参与炎症反应和免疫细胞浸润;STRING蛋白质分析网络显示,MYH10可能与MYL6B、MYL6、MYL9、MYL12B、CDC42、MYL1、MYLPF、MYH9、MYL2、MYLK等蛋白相互作用。结论 MYH10在肾透明细胞癌中呈低表达,其表达水平与肾透明细胞癌患者生存与预后有关,MYH10可能通过参与炎症反应和免疫细胞浸润影响肾透明细胞癌患者的临床结局。
Abstract:
Objective To analyze the expression level and significance of MYH10 gene in renal clear cell carcinoma.Methods The differential expression, tumor grade, promoter methylation and prognosis of MYH10 gene in renal clear cell carcinoma and normal control tissues were analyzed by ualcan database. The expression and tumor grade of MYH10 gene were retrieved by GEPIA database. The effect of MYH10 gene expression on the survival time of patients with renal clear cell carcinoma was analyzed by GEPIA database. The genes co-expressed with MYH10 in renal clear cell carcinoma were retrieved by Oncomine database. The correlation between MYH10 and co-expressed genes was analyzed by GEPIA. The protein interaction network of MYH10 was analyzed by String database.Results The expression level of MYH10 in renal clear cell carcinoma was lower than that in normal tissues (P<0.05). The overexpression of MYH10 was related to tumor grade, and the expression of MYH10 decreased with the increase of grade (P<0.05). The low expression of MYH10 gene was related to the low survival rate (P<0.05). The co-expression of MYH10 and RAB3A was significantly correlated. MYH10 could be involved in inflammatory response and immune cell infiltration. STRING protein analysis network showed that MYH10 might interact with MYL6B, MYL6, MYL9, MYL12B, CDC42, MYL1, MYLPF, MYH9, MYL2, MYLK and other proteins.Conclusion MYH10 is low expressed in renal clear cell carcinoma, and its expression level is related to the survival and prognosis of patients with renal clear cell carcinoma. MYH10 may affect the clinical outcome of patients with renal clear cell carcinoma by participating in inflammatory response and immune cell infiltration.

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更新日期/Last Update: 1900-01-01